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3.4.22.53: calpain-2

This is an abbreviated version!
For detailed information about calpain-2, go to the full flat file.

Word Map on EC 3.4.22.53

Reaction

broad endopeptidase specificity =

Synonyms

Cal II, calcium-activated neutral protease II, calpain 2, calpain II, calpain xCL-2 (Xenopus leavis), calpain-2, calpain-2-like, calpain2, CAPN II, CAPN2, CAPN2 g.p. (Homo sapiens), CPN2, cysteine protease, EC 3.4.22.17, EC 3.4.24.5, human calpain 2, m-calpain, milli-calpain, mitochondrial m-calpain, nCL-2, rat calpain 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.53 calpain-2

Source Tissue

Source Tissue on EC 3.4.22.53 - calpain-2

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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calpain 2 is important for both the formation of invadopodia and invasive capacity of breast cancer cells
Manually annotated by BRENDA team
cell line DLD-1. In KRASWT/- cells serum starvation induces CAPN2 expression, nucleolar accumulation
Manually annotated by BRENDA team
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nCL-2 is localized strictly to the surface cells in the gastric epithelium and the mucus-secreting goblet cells in the duodenum
Manually annotated by BRENDA team
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analysis from E8.5 to 14.5 stages indicates high levels of capn2 expression in the nervous system, heart and mesodermal tissues. Up-regulation is maintained during later developmental stages in proliferating cells and in precursor cells involved in muscle (myoblasts) or bone formation (chondrocytes). At later developmental stages, elevated mRNA levels coincide with CAPN2 nuclear localization in these cell types, while differentiated cells maintain cytoplasmic expression
Manually annotated by BRENDA team
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pulmonary microvascular endothelial cell. Incubation of the cells with vascular endothelial growth factor results in dose- and time-dependent increases in calpain activity and protein content of calpain-2. Vascular endothelial growth factor does not change the protein contents of calpain-1 and the small subunit or of calpastatin. Inhibition of calpain activity by siRNA directed against calpain-2 and by overexpression of calpastatin prevents vascular endothelial growth factor-induced increases in actin stress fibers in endothelial cells and angiogenesis
Manually annotated by BRENDA team
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calpain 2 is first expressed late in embryonic development and localizes to the lens epithelium and transition zone
Manually annotated by BRENDA team
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nCL-2 is localized strictly to the surface cells in the gastric epithelium and the mucus-secreting goblet cells in the duodenum
Manually annotated by BRENDA team
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calpain 2 localizes to GM-3-rich lipid rafts at the leading edge
Manually annotated by BRENDA team
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prefominantly localized in the growing hyphal and rhizoidal apices
Manually annotated by BRENDA team
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membrane abnormalities and altered signaling pathways observed in Duchenne muscular dystrophy lymphocytes may be due to the increased association of calpain II onto membrane and cytosol
Manually annotated by BRENDA team
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fibro-cartilagenous disks from meniscal tissue explants
Manually annotated by BRENDA team
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primary neutrophil
Manually annotated by BRENDA team
the large catalytic subunits of calpains 2 and the small regulatory subunit common to calpains 1 and 2 are weakly expressed in the parotid gland, sublingual gland, and submandibular gland at similar levels in males and females
Manually annotated by BRENDA team
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outer segment
Manually annotated by BRENDA team
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originated from kidney
Manually annotated by BRENDA team
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calpain 2 activity is critical for the life cycle of echovirus 1 and important in the multiplication of the viral RNA genome
Manually annotated by BRENDA team
the large catalytic subunits of calpains 2 and the small regulatory subunit common to calpains 1 and 2 are weakly expressed in the parotid gland, sublingual gland, and submandibular gland at similar levels in males and females
Manually annotated by BRENDA team
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active calpain 2 is concentrated in the trailing edge of the migrating T cell
Manually annotated by BRENDA team
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physiological shear stress elicits Ca2+ influx-sensitive activation of m-calain in umbilical vein endothelial cells
Manually annotated by BRENDA team
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present in very low amounts, only 0.0033%
Manually annotated by BRENDA team