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Literature summary for 3.4.22.53 extracted from

  • Miyazaki, T.; Honda, K.; Ohata, H.
    m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions (2010), Cardiovasc. Res., 85, 530-541.
    View publication on PubMed
Search for more literature for 3.4.22.53

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-L-leucyl-L-leucyl-L-methioninal
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta relatively high m-calpain expression levels in the inferior arch Mus musculus
-
vascular endothelial cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
m-calpain
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus m-calpain expression levels in aorta in siRNAtreated mice are significantly diminished by 63.5% in comparison to those in control RNA-transfected mice with no alteration of m-calpain or beta-actin expression down

General Information

General Information Comment Organism
malfunction short interfering RNA-induced silencing of m-calpain results in increased RhoA activity and hyperpermeability in the aortic arch, which is accompanied by ROCK inhibitor-sensitive phosphorylation of downstream effecter LIM kinase 2, stress fibre accumulation in endothelium and enhanced interendothelial gaps Mus musculus
physiological function m-calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions Mus musculus