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3.4.22.53: calpain-2

This is an abbreviated version!
For detailed information about calpain-2, go to the full flat file.

Word Map on EC 3.4.22.53

Reaction

broad endopeptidase specificity =

Synonyms

Cal II, calcium-activated neutral protease II, calpain 2, calpain II, calpain xCL-2 (Xenopus leavis), calpain-2, calpain-2-like, calpain2, CAPN II, CAPN2, CAPN2 g.p. (Homo sapiens), CPN2, cysteine protease, EC 3.4.22.17, EC 3.4.24.5, human calpain 2, m-calpain, milli-calpain, mitochondrial m-calpain, nCL-2, rat calpain 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.53 calpain-2

Inhibitors

Inhibitors on EC 3.4.22.53 - calpain-2

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
-
-
(2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid
-
-
(2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester
-
0.01 mM, 50% inhibition
1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(acetoxymethyl) ester
-
-
110 kDa calpastatin
-
-
-
3,4-dichloroisocoumarin
-
0.05 mM, 11% inhibition
4-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
-
5 mM, 23% inhibition
70 kDa calpastatin
-
-
-
Ac-Thr-Pro-Leu-alpha-azaglycine-Ser-Pro-Pro-NH2
-
-
Ac-Thr-Pro-Leu-alpha-azaglycine-Ser-Pro-Pro-Pro-Ser-NH2
-
-
Ac-Thr-Pro-Leu-alpha-azaglycine-Ser-Pro-Pro-Pro-Ser-Pro-Arg-NH2
-
-
Ac-Thr-Ser-Leu-alpha-azaglycine-Ser-Pro-Pro-Pro-Ser-NH2
-
-
Ac-Thr-Trp-Leu-alpha-azaglycine-Ser-Pro-Pro-Pro-Ser-NH2
-
-
acetyl-Leu-Leu-Met-CHO
-
selectively inhibits the activity of calpain-2
acetyl-Leu-Leu-Nle-CHO
Al3+
-
inactivation at millimolar concentration of Ca2+
ALLN
-
-
alpha2-Macroglobulin
-
0.05 mg/ml, 11% inhibition
-
antipain
benzyloxycarbonyl-L-leucyl-L-leucinal
-
-
benzyloxycarbonyl-Leu-Abu-CONH-CH2-C6H3(3,5-(OMe)2)
calpain-2 selective inhibitor. A selective calpain-2 inhibitor could prevent acute glaucoma-induced retinal ganglion cell death and blindness
benzyloxycarbonyl-Leu-Leu-leucinal
-
-
benzyloxycarbonyl-Leu-Leu-phenylalaninal
-
-
benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone
-
-
benzyloxycarbonyl-Leu-norleucinal
-
-
benzyloxycarbonyl-LLY-fluoromethylketone
-
-
Ca2+
initiation of autolysis of calpain 2 by adding of 1 mM CaCl2
Calmidazolium
-
calpain-specific inhibitor
calpain inhibitor I
calpain inhibitor II
calpastatin
-
calpastatin II
-
-
-
calpeptin
caplastatin 2
-
-
-
Cbz-Leu-DL-Abu-CONH-(CH2)3-(4-methylpiperazin-1-yl)
-
-
Cbz-Leu-DL-Abu-CONH-(CH2)3-2-methoxyadenin-9-yl
-
-
Cbz-Leu-DL-Abu-CONH-(CH2)3-adenin-9-yl
-
-
Cbz-Leu-DL-Abu-CONH-(CH2)3-cytosin-3-yl
-
-
Cbz-Leu-DL-Abu-CONH-(CH2)3-morpholine
-
-
CBZ-Leu-DL-Phe-CONH-(CH2)2-N-(CH3)2
-
-
CBZ-Leu-DL-Phe-CONH-(CH2)3-(4-methylpiperazin-1-yl)
-
-
CBZ-Leu-DL-Phe-CONH-(CH2)3-2-methoxyadenin-9-yl
-
-
CBZ-Leu-DL-Phe-CONH-(CH2)3-adenin-9-yl
-
best inhibitor
CBZ-Leu-DL-Phe-CONH-(CH2)3-cytosin-3-yl
-
-
CBZ-Leu-DL-Phe-CONH-(CH2)3-N-(CH3)2
-
-
E-64c
-
0.01 mM, 80-90% inhibition
Ep-475
-
0.001 mM, 49% inhibition of the enzyme from retina, 46% inhibition of the enzyme from brain
ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
-
-
GAP-43-3
-
indomethacin
-
-
iodoacetamide
-
1 mM, 64% inhibition
iodoacetic acid
leupeptin
MDL-28170
-
-
MDL28170
Mg2+
-
5 mM, inhibits in presence of 5 mM Ca2+
Mn2+
-
2.5 mM, strong
N-acetyl-L-leucyl-L-leucyl-L-methioninal
-
-
N-acetyl-Leu-Leu-Met
-
-
N-tosyl-Lys-chloromethyl ketone
-
0.5 mM, 69% inhibition
N-tosyl-Phe-chloromethyl ketone
-
0.5 mM, 91% inhibition
NaCl
-
m-calpain is more active at 165 mM NaCl than at 295 mM NaCl
NS-398
-
-
PD150606
pepstatin
-
0.01 mM, 99% inhibition
pepstatin A
-
1 mM, 60-80% inhibition
PMSF
-
1 mM, 6% inhibition
Polyethylene glycol
-
PEG-4000, PEG-100000 or PEG-20000, inhibition at concentrations higher than 0.5%
protease inhibitor
-
0.002 mg/ml, 6% inhibition
-
SC-560
-
-
SNJ-1945
-
-
Thr-Pro-Leu-alpha-azaglycine-Ser-Pro-Pro-Pro-Ser-Pro-Arg-NH2
-
-
TLCK
-
0.1 mM, 60-80% inhibition
Z-Val-Phe-CHO
-
i.e. MDL-28710m, 1.0 microM
additional information
-