3.4.21.B2: granzyme M
This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.
Word Map on EC 3.4.21.B2
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3.4.21.B2
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lymphocyte
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granule
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killer
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perforin
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medicine
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cell-mediated
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virus-infected
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cytolysis
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pore-forming
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caspase-independent
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thiobenzyl
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serpins
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perforin-dependent
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m-mediated
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norleucine
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noncytotoxic
- 3.4.21.B2
- lymphocyte
- granule
-
killer
- perforin
- medicine
-
cell-mediated
-
virus-infected
-
cytolysis
-
pore-forming
-
caspase-independent
-
thiobenzyl
- serpins
-
perforin-dependent
-
m-mediated
- norleucine
-
noncytotoxic
Reaction
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =
Synonyms
Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139
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Natural Substrates Products
Natural Substrates Products on EC 3.4.21.B2 - granzyme M
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REACTION DIAGRAM
alpha-tubulin + H2O
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direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo
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ezrin + H2O
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granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin
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heterogeneous nuclear ribonucleoprotein K + H2O
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granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function
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nucleophosmin + H2O
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the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated. Targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function
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participates in target cell death inflicted by cytotoxic lymphocytes
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additional information
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involved in granule exocytosis form of target cell death induced by cytotoxic lymphocytes
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additional information
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isolated granzyme M induces cell death and disorganizes the microtubule network by targeting alpha-tubulin. Granzyme M inactivates the GzmB inhibitor protease inhibitor 9, thereby increasing the susceptibility of target cells to granzyme B-induced apoptosis
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