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3.4.21.B2: granzyme M

This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.

Word Map on EC 3.4.21.B2

Reaction

endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =

Synonyms

Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B2 granzyme M

Natural Substrates Products

Natural Substrates Products on EC 3.4.21.B2 - granzyme M

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-tubulin + H2O
?
show the reaction diagram
direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo
-
-
?
ezrin + H2O
?
show the reaction diagram
granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin
-
-
?
heterogeneous nuclear ribonucleoprotein K + H2O
?
show the reaction diagram
-
granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function
-
?
nucleophosmin + H2O
?
show the reaction diagram
the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated. Targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function
-
-
?
Protein + H2O
?
show the reaction diagram
additional information
?
-