3.4.21.B2: granzyme M
This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.
Word Map on EC 3.4.21.B2
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3.4.21.B2
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lymphocyte
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granule
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killer
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perforin
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medicine
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cell-mediated
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virus-infected
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cytolysis
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pore-forming
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caspase-independent
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thiobenzyl
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serpins
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perforin-dependent
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m-mediated
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norleucine
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noncytotoxic
- 3.4.21.B2
- lymphocyte
- granule
-
killer
- perforin
- medicine
-
cell-mediated
-
virus-infected
-
cytolysis
-
pore-forming
-
caspase-independent
-
thiobenzyl
- serpins
-
perforin-dependent
-
m-mediated
- norleucine
-
noncytotoxic
Reaction
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =
Synonyms
Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139
ECTree
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Engineering
Engineering on EC 3.4.21.B2 - granzyme M
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D86N
K179M
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reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1
S182A
S201G
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reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1
additional information
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GrzM-deficient mice, which display altered murine CMV pathology and normal recovery from ectromelia virus infection