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3.4.21.B2: granzyme M

This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.

Word Map on EC 3.4.21.B2

Reaction

endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =

Synonyms

Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B2 granzyme M

Engineering

Engineering on EC 3.4.21.B2 - granzyme M

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K179M
-
reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1
S182A
S195A
inactive
S201G
-
reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1
additional information
-
GrzM-deficient mice, which display altered murine CMV pathology and normal recovery from ectromelia virus infection