3.4.21.B2: granzyme M
This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.
Word Map on EC 3.4.21.B2
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3.4.21.B2
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lymphocyte
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granule
-
killer
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perforin
-
medicine
-
cell-mediated
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virus-infected
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cytolysis
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pore-forming
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caspase-independent
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thiobenzyl
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serpins
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perforin-dependent
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m-mediated
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norleucine
-
noncytotoxic
- 3.4.21.B2
- lymphocyte
- granule
-
killer
- perforin
- medicine
-
cell-mediated
-
virus-infected
-
cytolysis
-
pore-forming
-
caspase-independent
-
thiobenzyl
- serpins
-
perforin-dependent
-
m-mediated
- norleucine
-
noncytotoxic
Reaction
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =
Synonyms
Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139
ECTree
3.4.21.B2 granzyme MAdvanced search results
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results (Expression
Expression on EC 3.4.21.B2 - granzyme M
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EXPRESSION 
ORGANISM
UNIPROT
LITERATURE
CD4+ T cells hardly express GrM (only 4%). GrM protein expression is absent in non-T non-natural killer cells in peripheral blood mononuclear cells
granzyme M is expressed by lymphocytes of both the innate and adaptive immune system: high expression by natural killer cells, natural killer T cells, and gammadelta T cells (70-80% of cells). CD8+ T cells also express GrM (ca. 50% of cells) and comparing the naive to early effector-memory, to late effectormemory, to effector subset, this expression gradually increases during differentiation (in particular by the differentiated effector CD27- CD45RO- subset). GrM is usually co-expressed with perforin (ca. 60% of cells). In CD8+ T cells, about 90% of GrM positive cells also express GrB
GrM protein expression by lymphocyte populations is not significantly affected by a panel of GrB-inducing cytokines
