3.4.21.B2: granzyme M
This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.
Word Map on EC 3.4.21.B2
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3.4.21.B2
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lymphocyte
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granule
-
killer
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perforin
-
medicine
-
cell-mediated
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virus-infected
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cytolysis
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pore-forming
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caspase-independent
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thiobenzyl
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serpins
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perforin-dependent
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m-mediated
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norleucine
-
noncytotoxic
- 3.4.21.B2
- lymphocyte
- granule
-
killer
- perforin
- medicine
-
cell-mediated
-
virus-infected
-
cytolysis
-
pore-forming
-
caspase-independent
-
thiobenzyl
- serpins
-
perforin-dependent
-
m-mediated
- norleucine
-
noncytotoxic
Reaction
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =
Synonyms
Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139
ECTree
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Source Tissue
Source Tissue on EC 3.4.21.B2 - granzyme M
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granzyme M is transiently elevated in the circulation following lipopolysaccharide administration in humans
additional information
CD4+ T cell, CD8+ T cell, natural killer T cell and gammadelta T cell
granzyme M is expressed by human cytomegalovirus-specific CD8+ T cells both in latently infected healthy individuals and in transplant patients during primary human cytomegalovirus infection
expressed in almost all NK, NKT and gammadelta T-cells and 35% of all Tc cells
additional information
present in KHYG-1 cells, absent from Jurkat T-cells