Literature summary for 3.4.21.B2 extracted from

Froelich, C.J.; Pardo, J.; Simon, M.M.
Granule-associated serine proteases: granzymes might not just be killer proteases (2009), Trends Immunol., 30, 117-123.

Search for more literature for 3.4.21.B2

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	isolated granzyme M induces cell death and disorganizes the microtubule network by targeting alpha-tubulin. Granzyme M inactivates the GzmB inhibitor protease inhibitor 9, thereby increasing the susceptibility of target cells to granzyme B-induced apoptosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P51124	-	-
Mus musculus	O08643	-	-
Rattus norvegicus	Q03238	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
natural killer cell	constitutively expressed	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isolated granzyme M induces cell death and disorganizes the microtubule network by targeting alpha-tubulin. Granzyme M inactivates the GzmB inhibitor protease inhibitor 9, thereby increasing the susceptibility of target cells to granzyme B-induced apoptosis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
GZmM	-	Homo sapiens
GZmM	-	Mus musculus
GZmM	-	Rattus norvegicus

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Release 2023.1 (January 2023)