3.4.21.B2: granzyme M

This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.

Word Map on EC 3.4.21.B2

3.4.21.B2

lymphocyte

granule

killer

perforin

medicine

cell-mediated

virus-infected

cytolysis

pore-forming

caspase-independent

thiobenzyl

serpins

perforin-dependent

m-mediated

norleucine

noncytotoxic

Reaction

endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =

Synonyms

Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B2 granzyme M

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Results	in table
1	Activating Compound
3	AA Sequence
6	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Crystallization (Commentary)
48	Disease/ Diagnostics
5	Expression
10	General Information
8	Inhibitors
43	KM Value [mM]
2	Localization
1	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
31	Organism
4	Posttranslational Modification
8	Protein Variants
5	Purification (Commentary)
1	Reaction
6	Reaction Type
31	Reference
29	Source Tissue
2	Storage Stability
58	Substrates and Products (Substrate)
26	Synonyms
47	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.B2 - granzyme M

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0.8

acetyl-KEPL-7-amido-4-methylcoumarin

-

-

2.4

acetyl-KEPM-7-amido-4-methylcoumarin

-

-

0.72

acetyl-KVAM-7-amido-4-methylcoumarin

-

-

0.37

acetyl-KVPL-7-amido-4-methylcoumarin

-

-

1.3

acetyl-KVPM-7-amido-4-methylcoumarin

-

-

0.4

acetyl-KYAL-7-amido-4-methylcoumarin

-

-

1

acetyl-KYPL-7-amido-4-methylcoumarin

-

-

2

acetyl-KYPM-7-amido-4-methylcoumarin

-

-

1.8

acetyl-MEPL-7-amido-4-methylcoumarin

-

-

1.5

acetyl-RYPL-7-amido-4-methylcoumarin

-

-

1.3

acetyl-VPL-7-amido-4-methylcoumarin

-

-

0.079 - 0.635

N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester

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0.188 - 1.02

N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester

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0.267 - 0.695

N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester

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0.793 - 3.89

N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester

show

0.22 - 0.694

N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester

show

0.21 - 2.66

N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester

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0.418 - 0.441

N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester

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0.361 - 0.894

N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester

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0.036 - 0.181

N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester

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0.0915 - 0.217

N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester

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0.92 - 6.65

N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester

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0.0334 - 0.129

N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester

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0.0366 - 0.0423

N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl

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0.0263 - 0.083

N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester

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Release 2023.1 (January 2023)