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Literature summary for 3.4.21.B2 extracted from

  • van Domselaar, R.; de Poot, S.A.; Remmerswaal, E.B.; Lai, K.W.; ten Berge, I.J.; Bovenschen, N.
    Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication (2013), Cell Death Differ., 20, 419-429.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine granzyme M is expressed by human cytomegalovirus-specific CD8+ T cells both in latently infected healthy individuals and in transplant patients during primary human cytomegalovirus infection. Host cell heterogeneous nuclear ribonucleoprotein K is a physiological granzyme M substrate. Granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function. Host cell heterogeneous nuclear ribonucleoprotein K is essential for hman cytomegalovirus replication not only by promoting viability of human cytomegalovirus-infected cells but predominantly by regulating viral immediate-early 2 protein levels. Granzyme M decreases viral immediate-early 2 protein expression in human cytomegalovirus-infected cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heterogeneous nuclear ribonucleoprotein K + H2O Homo sapiens
-
? granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51124
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte granzyme M is expressed by human cytomegalovirus-specific CD8+ T cells both in latently infected healthy individuals and in transplant patients during primary human cytomegalovirus infection Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heterogeneous nuclear ribonucleoprotein K + H2O
-
Homo sapiens ? granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function ?