Application | Comment | Organism |
---|---|---|
medicine | granzyme M is expressed by human cytomegalovirus-specific CD8+ T cells both in latently infected healthy individuals and in transplant patients during primary human cytomegalovirus infection. Host cell heterogeneous nuclear ribonucleoprotein K is a physiological granzyme M substrate. Granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function. Host cell heterogeneous nuclear ribonucleoprotein K is essential for hman cytomegalovirus replication not only by promoting viability of human cytomegalovirus-infected cells but predominantly by regulating viral immediate-early 2 protein levels. Granzyme M decreases viral immediate-early 2 protein expression in human cytomegalovirus-infected cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heterogeneous nuclear ribonucleoprotein K + H2O | Homo sapiens | - |
? | granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51124 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | granzyme M is expressed by human cytomegalovirus-specific CD8+ T cells both in latently infected healthy individuals and in transplant patients during primary human cytomegalovirus infection | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heterogeneous nuclear ribonucleoprotein K + H2O | - |
Homo sapiens | ? | granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function | ? |