Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytolytic granule | - |
Homo sapiens | 44194 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-tubulin + H2O | Homo sapiens | direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo | ? | - |
? | |
ezrin + H2O | Homo sapiens | granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51124 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
natural killer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-tubulin + H2O | direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo | Homo sapiens | ? | - |
? | |
alpha-tubulin + H2O | direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbed tubulin polymerization dynamics in vitro and induced microtubule network disorganization in tumor cells in vivo | Homo sapiens | ? | - |
? | |
ezrin + H2O | granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GrM | - |
Homo sapiens |