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Literature summary for 3.4.21.B2 extracted from

  • Smyth, M.J.; O'Connor, M.D.; Kelly, J.M.; Ganesvaran, P.; Thia, K.Y.; Trapani, J.A.
    Expression of recombinant human Met-ase-1: a NK cell-specific granzyme (1995), Biochem. Biophys. Res. Commun., 217, 675-683.
    View publication on PubMed
Search for more literature for 3.4.21.B2

Cloned(Commentary)

Cloned (Comment) Organism
wild-type, mutant with deletion of a dipeptide and mutant with deletion of a hexapeptide, expressed in COS cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in granule exocytosis form of target cell death induced by cytotoxic lymphocytes ?
-
 ?
Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
proteolytic modification first step requires cleavage of signal peptide resulting in an inactive zymogen with an amino-terminal activation propeptide, which must then be cleaved by another protease to generate a biologically active enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte CD3- large granular lymphocyte with natural killer cell activity Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hydrolyzes substrates containing a methionine-side chain at P1 Homo sapiens ?
-
 ?
additional information involved in granule exocytosis form of target cell death induced by cytotoxic lymphocytes Homo sapiens ?
-
 ?
N-tert-butoxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O activity only occurs with deletion mutants, but not with wild-type enzyme Homo sapiens N-tert-butoxycarbonyl-Ala-Ala-Met + phenylmethanethiol
-
 ?
Protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
hMet-1
-
 Homo sapiens
Met-ase-1
-
 Homo sapiens