3.4.21.B2: granzyme M
This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.
Word Map on EC 3.4.21.B2
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3.4.21.B2
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lymphocyte
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granule
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killer
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perforin
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medicine
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cell-mediated
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virus-infected
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cytolysis
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pore-forming
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caspase-independent
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thiobenzyl
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serpins
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perforin-dependent
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m-mediated
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norleucine
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noncytotoxic
- 3.4.21.B2
- lymphocyte
- granule
-
killer
- perforin
- medicine
-
cell-mediated
-
virus-infected
-
cytolysis
-
pore-forming
-
caspase-independent
-
thiobenzyl
- serpins
-
perforin-dependent
-
m-mediated
- norleucine
-
noncytotoxic
Reaction
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =
Synonyms
Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.B2 - granzyme M
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a series of peptide phosphonates and chloromethyl ketones tested, neither inhibitor type proved to be especially potent toward the enzyme, including the general serine protease inhibitor, 3,4-dichloroisocoumarin
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additional information
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a series of peptide phosphonates and chloromethyl ketones tested, neither inhibitor type proved to be especially potent toward the enzyme, including the general serine protease inhibitor, 3,4-dichloroisocoumarin
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additional information
noncleavable L138A survivin overexpression can significantly inhibit GzmM-mediated X-linked inhibitor of apoptosis protein degradation, caspase activation, and GzmM- and natural killer cell-induced cytotoxicity
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additional information
inhibitors bound to the granzyme active site show that the dimer also contributes to substrate specificity in a unique manner by extending the active-site cleft
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additional information
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inhibitors bound to the granzyme active site show that the dimer also contributes to substrate specificity in a unique manner by extending the active-site cleft
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additional information
a series of peptide phosphonates and chloromethyl ketones tested, neither inhibitor type proved to be especially potent toward the enzyme, including the general serine protease inhibitor, 3,4-dichloroisocoumarin
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