Literature summary for 3.4.21.B2 extracted from

Cullen, S.P.; Afonina, I.S.; Donadini, R.; Luethi, A.U.; Medema, J.P.; Bird, P.I.; Martin, S.J.
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing (2009), J. Biol. Chem., 284, 5137-5147.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nucleophosmin + H2O	Homo sapiens	the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated. Targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P51124	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleophosmin + H2O	the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated. Targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function	Homo sapiens	?	-	?
nucleophosmin + H2O	the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)