3.4.21.B2: granzyme M

This is an abbreviated version!
For detailed information about granzyme M, go to the full flat file.

Word Map on EC 3.4.21.B2

3.4.21.B2

lymphocyte

granule

killer

perforin

medicine

cell-mediated

virus-infected

cytolysis

pore-forming

caspase-independent

thiobenzyl

serpins

perforin-dependent

m-mediated

norleucine

noncytotoxic

Reaction

endopeptidase activity. Cleaves substrates containing a methionine side chain at P1 =

Synonyms

Granzyme M, GrM, GrzM, Gzm M, GZmM, hGzmM, hMet-1, Met-ase-1, S01.139

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B2 granzyme M

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Results	in table
1	Activating Compound
3	AA Sequence
6	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Crystallization (Commentary)
48	Disease/ Diagnostics
5	Expression
10	General Information
8	Inhibitors
43	KM Value [mM]
2	Localization
1	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
31	Organism
4	Posttranslational Modification
8	Protein Variants
5	Purification (Commentary)
1	Reaction
6	Reaction Type
31	Reference
29	Source Tissue
2	Storage Stability
58	Substrates and Products (Substrate)
26	Synonyms
47	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.B2 - granzyme M

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crystal structures of wild-type hGzmM, the inactive D86N-GzmM mutant with bound peptide substrate, and the complexes with a catalytic product and with a tetrapeptide chloromethylketone inhibitor are solved to 1.96 A, 2.30 A, 2.17 A and 2.70 A, respectively

Homo sapiens

P51124

693472