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3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Word Map on EC 3.4.15.1

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.15 Peptidyl-dipeptidases
                3.4.15.1 peptidyl-dipeptidase A

Turnover Number

Turnover Number on EC 3.4.15.1 - peptidyl-dipeptidase A

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
320 - 987
2-furanacryloyl-Phe-Gly-Gly
5520 - 7590
2-furylacryloyl-Phe-Gly-Gly
1.9
Abz-FRK(Dnp)P-OH
-
pH 9.5, 37°C
0.8 - 23
Abz-LFK(Dnp)-OH
3
Abz-SDK(Dnp)P-OH
-
pH 7.4, 37°C
4.2
amyloid beta-protein 1-42
-
-
-
0.58 - 8.33
angiotensin
0.03 - 60
angiotensin I
2.41
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Tyr-Arg
Drosophila sp. (in: flies)
-
35°C, pH 8.0
0.24
Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg
Drosophila sp. (in: flies)
-
35°C, pH 8.0
283
benzoyl-Gly-Gly-Gly
-
-
76.7 - 345
benzoyl-Gly-His-Leu
383
benzoyl-Gly-Phe-Arg
-
-
2.1 - 128
benzyloxycarbonyl-Phe-His-Leu
1.09 - 9.1
bradykinin
179 - 210
furanacryloyl-L-Phe-Gly-Gly
5.4 - 545
hippuryl-His-Leu
1.1
Ile-Ser-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Drosophila sp. (in: flies)
-
35°C, pH 8.0
11.7
Leu5-enkephalin
-
-
51 - 230
LVVYPWTQRY
20.33
Mca-RPPGFSAFK(Dnp)-OH
-
pH 7.4, 37°C
58.3
Met5-enkephalin
-
-
18.8
MKRSRGPSPRR
Drosophila sp. (in: flies)
-
35°C, pH 8.0
178
N-(3-(2-furyl)acryloyl)-Phe-Ala-Ala
-
pH 7.5, 25°C, enzyme from testis
35 - 85
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys
8 - 45
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro
260 - 315
N-(3-(2-furyl)acryloyl)-Phe-Gly-Gly
30 - 76
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg
987.3
N-(3-[2-furyl]acryloyl)-L-phenylalanylglycylglycine
pH 7.5, 22°C
12
N-benzyloxycarbonyl-L-Phe-L-His-L-Leu
-
pH 7.5, 25°C, enzyme from testis
6.5
N-hippuryl-His-Leu
-
pH 7.5, 25°C
0.567
neurotensin
-
-
31 - 101.7
o-aminobenzoyl-FDK-(dinitrophenyl)-P-OH
26.7 - 69.2
o-aminobenzoyl-FRK-(dinitrophenyl)-P-OH
1 - 3.3
o-aminobenzoyl-GFSPFAQ-(N-2,4-dinitrophenyl)ethylenediamine
2.2
o-aminobenzoyl-GFSPFEQ-(N-2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C, wild-type enzyme
2.4 - 12.6
o-aminobenzoyl-GFSPFFQ-(N-2,4-dinitrophenyl)ethylenediamine
3 - 4.8
o-aminobenzoyl-GFSPFLQ-(N-2,4-dinitrophenyl)ethylenediamine
0.3 - 2
o-aminobenzoyl-GFSPFQQ-(N-2,4-dinitrophenyl)ethylenediamine
3.4 - 10.4
o-aminobenzoyl-GFSPFRA-(N-2,4-dinitrophenyl)ethylenediamine
1 - 4.2
o-aminobenzoyl-GFSPFRF-(N-2,4-dinitrophenyl)ethylenediamine
2.6 - 8.7
o-aminobenzoyl-GFSPFRI-(N-2,4-dinitrophenyl)ethylenediamine
1.8 - 3.8
o-aminobenzoyl-GFSPFRN-(N-2,4-dinitrophenyl)ethylenediamine
2.2 - 4.2
o-aminobenzoyl-GFSPFRQ-(N-2,4-dinitrophenyl)ethylenediamine
0.9 - 1.4
o-aminobenzoyl-GFSPFRR-(N-2,4-dinitrophenyl)ethylenediamine
0.9 - 2.4
o-aminobenzoyl-GFSPFRS-(N-2,4-dinitrophenyl)ethylenediamine
0.8 - 2.3
o-aminobenzoyl-GFSPFSQ-(N-2,4-dinitrophenyl)ethylenediamine
0.1 - 44.2
o-aminobenzoyl-SDK-(dinitrophenyl)-P-OH
13.7 - 28.6
o-aminobenzoyl-SRK-(dinitrophenyl)-P-OH
0.06 - 36.3
o-aminobenzoyl-TDK-(dinitrophenyl)-P-OH
0.2 - 82
o-aminobenzoyl-TRK-(dinitrophenyl)-P-OH
7 - 62.5
o-aminobenzoyl-YDK-(dinitrophenyl)-P-OH
1.01 - 85.6
o-aminobenzoyl-YRK-(dinitrophenyl)-P-OH
3.75 - 21.3
Substance P
5.83
TOAC1-angiotensin I
-
-
2.56
TOAC3-angiotensin I
-
-
57 - 460
[Arg10]angiotensin I
6.5 - 1700
[Phe9,Arg10]angiotensin I
110 - 1500
[Phe9]angiotensin I
additional information
additional information
-