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3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Word Map on EC 3.4.15.1

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.15 Peptidyl-dipeptidases
                3.4.15.1 peptidyl-dipeptidase A

Purification

Purification on EC 3.4.15.1 - peptidyl-dipeptidase A

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ACE and cobalt-ACE
-
captopril affinity chromatography
-
large scale
-
lung and kidney enzyme partially by acetone extraction
-
N-catalytic domain (residues Ala361 to Gly468) of human somatic angiotensin-I converting enzyme expressed in Escherichia coli
native enzyme 447fold from lung by ammonium sulfate fractionation, gel filtration, and anion exchange chromatography, followed by ultrafiltration
native enzyme, nucleus preparation, gel filtration
-
recombinant enzyme
Drosophila sp. (in: flies)
-
recombinant enzyme from Escherichia coli strain BL21(DE3) to homogeneity
recombinant enzyme from Pichia pastoris by hydrophobic interaction chromatography and gel filtration to homogeneity
Sepharose-lisinopril affinity chromatography
using affinity chromatography and gel filtration
-