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3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Word Map on EC 3.4.15.1

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.15 Peptidyl-dipeptidases
                3.4.15.1 peptidyl-dipeptidase A

Source Tissue

Source Tissue on EC 3.4.15.1 - peptidyl-dipeptidase A

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
ACE is expressed in osteoblasts and hypertrophic chondrocytes in the periosteal callus during fracture healing, accompanied by expression of the angiotensin type-1 and type-2 receptors
Manually annotated by BRENDA team
high ACE peptidase activity coincides with every transition state, from embryo to larva, from larva to larva and from larva to pupa
Manually annotated by BRENDA team
-
at 11-13 weeks of gestation ACE-positive cells are observed in the primitive epidermis, as the fetuses develops ACE-positive cells appear in all the epidermal layers, and from 21 weeks of gestation ACE expression is largely restricted to the basal layer of the fetal epidermis, while ACE-positive cells are found only in the adult skin basal layer which harbours epidermal stem cells
Manually annotated by BRENDA team
-
brush border of absorptive epithelia on the small intestine and the renal convoluted tubule
Manually annotated by BRENDA team
-
weak activity
Manually annotated by BRENDA team
of the last larval stage
Manually annotated by BRENDA team
-
cultured, corneal
Manually annotated by BRENDA team
-
ischemic and contralateral non-ischemic legs
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
stably transfected with full-length ACE2
Manually annotated by BRENDA team
of the last larval stage
Manually annotated by BRENDA team
-
endogenously expressing ACE2
Manually annotated by BRENDA team
-
intestinal mucosa and arteries
Manually annotated by BRENDA team
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dorsomedial medulla
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
high ACE peptidase activity coincides with every transition state, from embryo to larva, from larva to larva and from larva to pupa. pupa. A peak value in activity occurs during the early pupal stage
Manually annotated by BRENDA team
-
from aorta, extracellular ACE binds to smooth muscle cells, overview
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse cultured spermatogonial stem cells (SSCs)
Manually annotated by BRENDA team
stably overexpressing human somatic ACE
Manually annotated by BRENDA team
additional information