3.4.15.1: peptidyl-dipeptidase A
This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.
Word Map on EC 3.4.15.1
-
3.4.15.1
-
hypertension
-
blocker
-
cardiovascular
-
arterial
-
antihypertensive
-
cardiac
-
renin-angiotensin
-
ventricular
-
myocardial
-
captopril
-
systolic
-
diuretic
-
coronary
-
renin
-
aceis
-
infarction
-
beta-blockers
-
enalapril
-
glomerular
-
diastolic
-
ejection
-
proteinuria
-
mellitus
-
placebo
-
hypertrophy
-
aldosterone
-
nephropathy
-
creatinine
-
hemodynamic
-
bradykinin
-
congestive
-
ras
-
vasodilator
-
normotensive
-
statin
-
renin-angiotensin-aldosterone
-
hg
-
sarcoidosis
-
losartan
-
aspirin
-
prescript
-
double-blind
-
angiotensinogen
-
renoprotective
-
pressor
-
digoxin
-
all-cause
-
renovascular
-
microalbuminuria
-
hypotensive
-
drug development
-
veterinary medicine
-
medicine
- 3.4.15.1
- hypertension
-
blocker
- cardiovascular
- arterial
-
antihypertensive
- cardiac
-
renin-angiotensin
- ventricular
- myocardial
- captopril
-
systolic
-
diuretic
- coronary
- renin
-
aceis
- infarction
-
beta-blockers
- enalapril
- glomerular
-
diastolic
-
ejection
- proteinuria
- mellitus
-
placebo
- hypertrophy
- aldosterone
- nephropathy
- creatinine
-
hemodynamic
- bradykinin
-
congestive
- ras
-
vasodilator
-
normotensive
- statin
-
renin-angiotensin-aldosterone
- hg
- sarcoidosis
- losartan
- aspirin
-
prescript
-
double-blind
- angiotensinogen
-
renoprotective
-
pressor
- digoxin
-
all-cause
-
renovascular
-
microalbuminuria
-
hypotensive
- drug development
- veterinary medicine
- medicine
Reaction
release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =
Synonyms
ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase
ECTree
3.4.15.1 peptidyl-dipeptidase AAdvanced search results
results (
results (IC50 Value
IC50 Value on EC 3.4.15.1 - peptidyl-dipeptidase A
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.219
(2E)-3-(3-amino-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.57
(2E)-3-(3-fluoro-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.246
(2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.552
(2E)-3-(3-hydroxy-4-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.574
(2E)-3-(3-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.225
(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.516
(2E)-3-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.622
(2E)-3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Oryctolagus cuniculus
-
37°C
0.0033
(2S)-1-((3S)-3-amino-3-carboxypropyl)azetidine-2-carboxylic acid
Oryctolagus cuniculus
-
IC50: 0.0033 mM
0.805
1-methyl-5-phenyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Oryctolagus cuniculus
-
37°C
0.00008
2''-hydroxynicotianamide
Oryctolagus cuniculus
-
angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour, IC50: 0.00008 mM
0.674
2-methoxy-4-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
Oryctolagus cuniculus
-
37°C
0.749
2-methoxy-5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]aniline
Oryctolagus cuniculus
-
37°C
0.762
2-methoxy-5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
Oryctolagus cuniculus
-
37°C
0.77
5-(3-fluoro-4-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Oryctolagus cuniculus
-
37°C
0.889
5-(3-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Oryctolagus cuniculus
-
37°C
0.213
5-(4-methoxy-3-nitrophenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Oryctolagus cuniculus
-
37°C
0.435
5-(4-methoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Oryctolagus cuniculus
-
37°C
0.599
5-[1-methyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]-2-nitrophenol
Oryctolagus cuniculus
-
37°C
0.021
Asn-Trp-Gly-Pro-Leu-Val
Homo sapiens
-
pH and temperature not specified in the publication
0.0034
Asp-Ile-Gly-Tyr-Tyr
Homo sapiens
-
pH and temperature not specified in the publication
0.00072
Asp-Tyr-Val-Gly-Asn
Homo sapiens
-
pH and temperature not specified in the publication
0.00074
Gly-Gly-Val-Ile-Pro-Asn
Homo sapiens
-
pH and temperature not specified in the publication
0.0294
Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro
Oryctolagus cuniculus
-
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C
0.0456
Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly
Oryctolagus cuniculus
-
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C
0.0434
Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly
Oryctolagus cuniculus
-
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C
0.0608
Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly
Oryctolagus cuniculus
-
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C
0.00554
Gly-L-Thr-Gly
Oryctolagus cuniculus
-
in 0.02 mM sodium borate buffer (pH 8.3), at 37°C
0.026
Gly-Phe-Hyp-Gly-Thr-Hyp-Gly-Leu-Hyp-Gly-Phe
Oryctolagus cuniculus
-
IC50: 0.026 mM. Inhibitory peptide derived from chicken breast muscle
0.008
HERDPTHIKWGD
Oryctolagus cuniculus
-
IC50: about 0.008 mM. Production kinetics of angiotensin-I converting enzyme inhibitory peptides from bonito meat in artificial gastric juice
0.0042
Ile-Ala-Tyr-Lys-Pro-Ala-Gly
Homo sapiens
-
pH and temperature not specified in the publication
0.0175
Ile-Pro-Pro-Gly-Val-Pro-Tyr
Homo sapiens
-
pH and temperature not specified in the publication
0.064
Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr
Homo sapiens
-
pH and temperature not specified in the publication
0.0065
L-Ala-L-Trp
Oryctolagus cuniculus
-
in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C
0.00215
L-Asp-L-Pro
Oryctolagus cuniculus
-
in 0.02 mM sodium borate buffer (pH 8.3), at 37°C
0.00876
L-Glu-L-Arg-L-Tyr-L-Pro-L-Ile
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.00878
L-Ile-L-Pro-L-Phe
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.01059
L-Leu-L-Pro-L-Phe
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.01798
L-Met-L-Pro-L-Phe
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.00403
L-Ser-L-Thr
Oryctolagus cuniculus
-
in 0.02 mM sodium borate buffer (pH 8.3), at 37°C
0.02494
L-Thr-L-Thr-L-Ile
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.02338
L-Tyr-L-Thr-L-Ala-Gly-L-Val
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.00659
L-Val-L-Asp-L-Phe
Oryctolagus cuniculus
-
in 100 mM potassium phosphate buffer containing 300 mM NaCl, at 37°C
0.051
L-Val-L-Phe
Oryctolagus cuniculus
-
in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C
0.07
Leu-Ala-Ile-pro-Val-Asn-Lys-Pro
Homo sapiens
-
pH and temperature not specified in the publication
0.00038
Leu-Arg-Ile-Pro-Val-Ala
Homo sapiens
-
pH and temperature not specified in the publication
0.00082
Leu-Ile-Tyr
Oryctolagus cuniculus
-
i.e. acein-2, isolated from tryptic hydrolysate of human plasma, non-competitive inhibitor, IC50: 0.00082 mM.
0.0265
Lys-Asp-Tyr-Arg-Leu
Homo sapiens
-
pH and temperature not specified in the publication
0.0134
Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe
Homo sapiens
-
pH and temperature not specified in the publication
0.0021
Met-Arg-Trp-Arg-Asp
Homo sapiens
-
pH and temperature not specified in the publication
0.0147
Phe-Gly-Ala-Ser-Thr-Arg-Gly-Ala
Oryctolagus cuniculus
-
IC50: 0.0147 mM, noncompetitive
0.0069
Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser
Homo sapiens
-
pH and temperature not specified in the publication
0.09533
Pro-Arg-Tyr
Oryctolagus cuniculus
pH and temperature not specified in the publication
0.033
Pro-Asn-Asn-Lys-Pro-Phe-Gln
Homo sapiens
-
pH and temperature not specified in the publication
0.008
PTHIKWGD
Oryctolagus cuniculus
-
IC50: about 0.008 mM. Production kinetics of angiotensin-I converting enzyme inhibitory peptides from bonito meat in artificial gastric juice
0.351
quercetin 3-O-alpha-(6''-p-coumaroylglucosyl-beta -1,2-rhamnoside)
Rattus norvegicus
-
IC50: 0.351 mM
0.1589
quercetin-3-O-alpha-(6''-caffeoylglucosyl-beta-1,2-rhamnoside)
Rattus norvegicus
-
IC50: 0.1589 mM
0.00086
Thr-Tyr-Leu-Gly-Ser
Homo sapiens
-
pH and temperature not specified in the publication
0.0022
Thr-Val-Val-Pro-Gly
Homo sapiens
-
pH and temperature not specified in the publication
0.11234
Trp-Gly
Oryctolagus cuniculus
pH and temperature not specified in the publication
0.0257
Trp-Val-Pro-Ser-Val-Tyr
Homo sapiens
-
pH and temperature not specified in the publication
0.014
Tyr-Leu-Ala-Gly-Asn-Gln
Homo sapiens
-
pH and temperature not specified in the publication
0.0264
Tyr-Tyr-Ala-Pro-Phe
Homo sapiens
-
pH and temperature not specified in the publication
0.083
Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu
Homo sapiens
-
pH and temperature not specified in the publication
0.097
Val-Ile-Glu-Lys-Tyr-Pro
Homo sapiens
-
pH and temperature not specified in the publication
0.039
Val-Met-Asp-Lys-Pro-Gln-Gly
Homo sapiens
-
pH and temperature not specified in the publication
0.0824
Val-Thr-Pro-Ala-Leu-Arg
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
Ala-Pro-Gly-Ala-Gly-Val-Tyr
Homo sapiens
-
pH and temperature not specified in the publication
0.0027
Ala-Pro-Gly-Ala-Gly-Val-Tyr
Homo sapiens
-
pH and temperature not specified in the publication
0.00000687
captopril
Oryctolagus cuniculus
-
using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate, at 37°C
0.0122
L-Val-L-Tyr
Oryctolagus cuniculus
-
in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C
0.02956
L-Val-L-Tyr
Oryctolagus cuniculus
-
using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate, at 37°C
0.00000057
lisinopril
Oryctolagus cuniculus
-
using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate, at 37°C
0.00169
Val-Leu-Ile-Val-Pro
Sus scrofa
-
IC50: 0.00169 mM. The peptide is resistant to digestion by proteases of the gastrointestinal tract. The antihypertensive property of this peptide derived from glycinin might find importance in the development of therapeutic functional foods
0.00169
Val-Leu-Ile-Val-Pro
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
[CB-TE2A]1--lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.000023
[CB-TE2A]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00062
[Co-DOTA]1--lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0029
[Co-DOTA]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00076
[Co-EDTA]1--lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0034
[Co-EDTA]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.000026
[Cu-CB-TE2A]1+-lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.000036
[Cu-CB-TE2A]1+-lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00053
[Cu-DOTA]1--lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0023
[Cu-DOTA]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00042
[Cu-EDTA]1--lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0021
[Cu-EDTA]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.000028
[Fe-CB-TE2A]2+-lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.00069
[Fe-CB-TE2A]2+-lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00019
[Fe-EDTA]0-lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00000044
[Fe-NTA]1+-lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.00003
[Ni-CB-TE2A]1+-lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.000032
[Ni-CB-TE2A]1+-lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.00083
[Ni-DOTA]1--lisinopril
Homo sapiens
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0033
[Ni-DOTA]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.0034
[Ni-EDTA]1--lisinopril
Homo sapiens
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
additional information
additional information
Sus scrofa
-
IC50-value of peptides purified from sunflower hydrolysate: 0.00118 mg/ml, IC50-value of peptides purified from rapeseed hydrolysate: 0.00025 mg/ml
-
additional information
additional information
Oryctolagus cuniculus
-
IC50-value of peptides purified from sunflower hydrolysate: 0.0023 mg/ml
-
additional information
additional information
Oryctolagus cuniculus
-
IC50 value of alcalase hydrolysate of Brachionus rotundiformis inhibitory peptides for ACE inhibitory activity is 0.63 mg/ml
-
additional information
additional information
Homo sapiens
-
IC50 values are 0.6179-0.5860 mM per 0.1-0.4 mg/l proteinhydrolysate BCAA-rich fraction, the FPH-mix with highest Fischer ratio, mixed-type inhibition pattern, inhibition kinetics of flaxseed peptides, overview
-
additional information
additional information
Homo sapiens
-
IC50 values for different parts of the milled wheat seed
-
additional information
additional information
Rattus norvegicus
-
IC50 values of nicotianamine, Val-Gly, Gly-Tyr, Ser-Tyr, Ala-Tyr, Ala-Ile, Val-Pro, Ala-Phe, Gly-Trp, and Ala-Trp are 0.442 mg/ml, 0.172 mg/ml, 0.132 mg/ml, 0.132 mg/ml, 0.132 mg/ml, 0.132 mg/ml, 0.172 mg/ml, 0.224 mg/ml, 0.199 mg/ml, and 0.199 mg/ml
-
additional information
additional information
Homo sapiens
-
nutrient sources of ACE inhibitory peptides derived from marine organisms, enzymes used for hydrolysis, and IC50 values, overview
-
