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3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Word Map on EC 3.4.15.1

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.15 Peptidyl-dipeptidases
                3.4.15.1 peptidyl-dipeptidase A

Molecular Weight

Molecular Weight on EC 3.4.15.1 - peptidyl-dipeptidase A

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
113000
-
gel filtration
126000
128500
-
x * 128500, equilibrium sedimentation under denaturing conditions
129000
130000
-
x * 130000, enzyme from lung, SDS-PAGE with 7% acryl amide
136000
-
glycerol density gradient centrifugation
139000
140000
145000
150000
150000 - 180000
-
somatic enzyme form in endothelial, epithelial, neuronal, and germinal cells, in germinal cells a second enzyme form of 90000-110000 Da exists, gel filtration
155000
160000
-
x * 160000, lung and kidney enzyme, SDS-PAGE with or without 1% 2-mercaptoethanol
165000
170000
180000
195000
-
x * 195000, enzyme from kidney, SDS-PAGE with 5% acryl amide
199000
-
equilibrium sedimentation
200000
206000
210000
-
gel filtration
230000
-
gel filtration
244000
gel filtration
270000
-
gel filtration
280000
-
gel filtration
290000
300000
-
gel filtration
320000
-
gel filtration
330000
-
enzyme from semen, gel filtration
55000
-
x * 55000 + x * 65000, SDS-PAGE
65000
-
x * 55000 + x * 65000, SDS-PAGE
69000
-
gel filtration
70000
71000
-
1 * 71000, SDS-PAGE
72000
74000
-
1 * 74000, SDS-PAGE
800000
-
gel filtration
84000
-
gel filtration
90000 - 110000
-
germinal cells, germinal cells also contain an enzyme form of MW 150000-180000 Da, gel filtration
91000
-
x * 91000, SDS-PAGE
94000
-
testicular enzyme, gel filtration
98000
-
enzyme form III, gel filtration