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3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Word Map on EC 3.4.15.1

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.15 Peptidyl-dipeptidases
                3.4.15.1 peptidyl-dipeptidase A

KI Value

KI Value on EC 3.4.15.1 - peptidyl-dipeptidase A

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00000061 - 0.00012
(2R)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
0.00000041 - 0.000024
(2S)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
0.0000004
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1([(benzyloxy)carbonyl]amino)ethyl)phosphinyl]-(2R)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-phenyl propanoic acid
-
pH and temperature not specified in the publication
0.0000014
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2R)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino) 1H-Indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.00000065
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2R)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
-
pH and temperature not specified in the publication
0.000012
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2S)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino) 1H-indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.0000038
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2S)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
-
pH and temperature not specified in the publication
0.000016
(2S)-2-([3-(1,1'-biphenyl)-2-([hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]amino)ethyl)phosphinyl]methyl)-1-oxopropyl]-amino) 1H-indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.000025
(2S)-2-([3-(3'-[1,1'-biphenyl]-4''-yl-4',5'-dihydro-5'-isoxazolyl)-2-([hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]amino)ethyl)-phosphinyl]methyl)-1-oxopropyl]amino) 1H-indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.0000022 - 0.0018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid
0.0000018 - 0.00031
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
0.0000015 - 0.00057
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid
0.000014 - 0.00018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
0.0000013 - 0.00041
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
0.0000015 - 0.02
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
0.0000015 - 0.001
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
0.0023 - 0.0034
(2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid
0.000016 - 0.00032
(2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid
0.0000014 - 0.0000086
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid
0.0000069 - 0.000021
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid
0.0000015 - 0.00049
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
0.00081 - 0.0181
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
0.000064 - 0.00974
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
0.0004 - 0.0008
(pE)KWAP
0.000003 - 0.0001
(pE)WPRPQIPP
0.0018 - 0.0452
1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline
0.0336 - 0.1435
1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline
0.000006 - 0.013
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
0.0000024 - 0.00075
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
0.000002747
angiotensin I
-
-
0.004 - 0.076
angiotensin II
0.035
angiotensin IV
-
pH 7.5
0.3176
Arg-Met-Leu
-
pH 8.5
0.365
benzyloxycarbonyl-PhePSI[PO2-CH]Ala-Ala
Drosophila sp. (in: flies)
-
35°C, pH 8.0
0.152
benzyloxycarbonyl-PhePSI[PO2-CH]Ala-Trp
Drosophila sp. (in: flies)
-
35°C, pH 8.0
0.000001278
bradykinin
-
-
0.0000003 - 0.000191
captopril
0.0569
cyanidin-3-O-sambubioside
-
pH 8.3, 37°C
0.0319
delphinidin-3-O-sambubioside
-
pH 8.3, 37°C
0.00000194
enalaprilat
-
-
0.828
epicatechin
-
pH 8.3, 37°C
0.124
epicatechin dimer
-
pH 8.3, 37°C
0.0047
epicatechin hexamer
-
pH 8.3, 37°C
0.0116
epicatechin pentamer
-
pH 8.3, 37°C
0.0056
epicatechin tetramer
-
pH 8.3, 37°C
0.059
epicatechin trimer
-
pH 8.3, 37°C
0.000083
gluco-aurantioobtusin
-
in 50 mM Tris-HCl buffer (pH 7.5)
0.5547
Gly-Gln
-
pH 8.5
0.01148
Gly-Phe-Hyp-Gly-Thr-Hyp-Gly-Leu-Hyp-Gly-Phe
-
37°C, pH 8.3
0.0072
Ile-Glu-Pro
-
-
0.055
Ile-Glu-Trp
-
-
0.0835
Ile-Glu-Tyr
-
-
0.0027
Ile-Lys-Pro
-
-
0.0085
Ile-Lys-Trp
-
-
0.013
Ile-Lys-Tyr
-
-
0.0005
Leu-Gln-Pro
-
-
0.00048
Leu-Lys-Tyr
-
-
0.00092
Leu-Val-Tyr
-
-
0.0028
LGFPTTKTYFPHF
-
-
0.0000001 - 0.00028
lisinopril
0.0000066 - 0.0017
lisW-S
0.0008 - 0.017
LRPARPTSPP
0.0003 - 0.017
LRPARPTSPPA
0.000013
N-(3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-{[3-(biphenyl-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}propanoyl)-L-tryptophan
-
pH and temperature not specified in the publication
0.0000009 - 0.005
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
0.0000024 - 0.0011
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
0.0000018 - 0.0007
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
0.000035 - 0.0026
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
0.0237 - 0.0843
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine
0.0008 - 0.1957
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan
0.043 - 0.3129
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine
0.0133 - 0.3813
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan
0.000005
N-[3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-(biphenyl-4-ylmethyl)propanoyl]-L-tryptophan
-
pH and temperature not specified in the publication
0.000036
N-{(2R)-3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine
-
pH and temperature not specified in the publication
0.00002
N-{(2S)-3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tryptophan
-
pH and temperature not specified in the publication
500
NaCl
-
-
0.0266
noncompetitive inhibitor
-
-
-
0.000002 - 0.00095
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0000085 - 0.0018
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0000025 - 0.004
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0000014 - 0.00057
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.000084 - 0.025
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0015 - 0.049
PARPTSPP
0.00000105
perindoprilat
-
-
0.0000015 - 0.0002
pGlu-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro
0.00003 - 0.01
pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro
0.00008
pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
0.000001 - 0.0001
pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
100
PO43-
-
-
0.02825
Pro-Arg-Tyr
pH and temperature not specified in the publication
0.00000035
quinaprilat
-
-
0.00000076
ramiprilat
-
-
0.1672
RMLGQ
-
pH 8.5
0.1215
RMLGQTP
-
pH 8.5
0.0606
RMLGQTPTK
-
pH 8.5
0.0009 - 0.023
RPARPTSPP
0.000007 - 0.004
RXP407
0.005 - 0.019
Ser-Pro-Pro
0.0024 - 0.2
SSYVHLRPARPTSPP
0.6164
Thr-Lys
-
pH 8.5
0.1004
Thr-Pro
-
pH 8.5
0.00000057
trandolaprilat
-
-
0.20027
Trp-Gly
pH and temperature not specified in the publication
0.0045
Val-Leu-Ile-Val-Pro
-
-
0.138
Val-Trp
-
pH 8.3, 37°C
0.203
Val-Tyr
-
pH 8.3, 37°C
0.00843
VVYPWT
-
-
0.0144
VVYPWTQRF
-
pH 7.5
0.0008 - 0.01
YVHLRPARPTSPP
0.000008 - 0.000018
[CB-TE2A]1--lisinopril
-
0.0003 - 0.0023
[Co-DOTA]1--lisinopril
-
0.00041 - 0.0027
[Co-EDTA]1--lisinopril
-
0.000027 - 0.000189
[Co-GGH]0-lisinopril
0.00000012 - 0.00004
[Co-NTA]0-lisinopril
0.000014 - 0.000028
[Cu-CB-TE2A]1+-lisinopril
-
0.00029 - 0.0018
[Cu-DOTA]1--lisinopril
-
0.00023 - 0.0017
[Cu-EDTA]1--lisinopril
-
0.0001 - 0.0019
[Cu-GGH]0-lisinopril
0.00000033 - 0.000038
[Cu-NTA]0-lisinopril
0.00034 - 0.0022
[DOTA]1--lisinopril
-
0.00014 - 0.00058
[EDTA]3-lisinopril
-
0.000015 - 0.00054
[Fe-CB-TE2A]2+-lisinopril
-
0.00042 - 0.0021
[Fe-DOTA]0-lisinopril
-
0.000016 - 0.00015
[Fe-EDTA]0-lisinopril
-
0.00000024 - 0.000035
[Fe-NTA]1+-lisinopril
0.000029 - 0.000102
[GGH]1+-lisinopril
0.000017 - 0.000023
[Ni-CB-TE2A]1+-lisinopril
-
0.00045 - 0.0026
[Ni-DOTA]1--lisinopril
-
0.00049 - 0.0026
[Ni-EDTA]1--lisinopril
-
0.00011 - 0.001
[Ni-GGH]0-lisinopril
0.00000026 - 0.000033
[Ni-NTA]0-lisinopril
0.00000031 - 0.000057
[NTA]2-lisinopril
0.00009 - 0.0014
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
additional information
additional information
-