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0.00000061 - 0.00012
(2R)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
0.00000041 - 0.000024
(2S)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
0.0000004
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1([(benzyloxy)carbonyl]amino)ethyl)phosphinyl]-(2R)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-phenyl propanoic acid
-
pH and temperature not specified in the publication
0.0000014
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2R)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino) 1H-Indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.00000065
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2R)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
-
pH and temperature not specified in the publication
0.000012
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2S)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino) 1H-indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.0000038
(2S)-2-((3-[hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]-amino)ethyl)phosphinyl]-(2S)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
-
pH and temperature not specified in the publication
0.000016
(2S)-2-([3-(1,1'-biphenyl)-2-([hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]amino)ethyl)phosphinyl]methyl)-1-oxopropyl]-amino) 1H-indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.000025
(2S)-2-([3-(3'-[1,1'-biphenyl]-4''-yl-4',5'-dihydro-5'-isoxazolyl)-2-([hydroxyl(2-phenyl-(1R)-1-([(benzyloxy)carbonyl]amino)ethyl)-phosphinyl]methyl)-1-oxopropyl]amino) 1H-indole-3-propanoic acid
-
pH and temperature not specified in the publication
0.0000022 - 0.0018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid
0.0000018 - 0.00031
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
0.0000015 - 0.00057
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid
0.000014 - 0.00018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
0.0000013 - 0.00041
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
0.0000015 - 0.02
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
0.0000015 - 0.001
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
0.0023 - 0.0034
(2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid
0.000016 - 0.00032
(2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid
0.0000014 - 0.0000086
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid
0.0000069 - 0.000021
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid
0.0000015 - 0.00049
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
0.00081 - 0.0181
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
0.000064 - 0.00974
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
0.000003 - 0.0001
(pE)WPRPQIPP
0.0018 - 0.0452
1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline
0.0336 - 0.1435
1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline
0.000006 - 0.013
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
0.0000024 - 0.00075
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
0.000002747
angiotensin I
-
-
0.004 - 0.076
angiotensin II
0.035
angiotensin IV
-
pH 7.5
0.3176
Arg-Met-Leu
-
pH 8.5
0.365
benzyloxycarbonyl-PhePSI[PO2-CH]Ala-Ala
Drosophila sp. (in: flies)
-
35°C, pH 8.0
0.152
benzyloxycarbonyl-PhePSI[PO2-CH]Ala-Trp
Drosophila sp. (in: flies)
-
35°C, pH 8.0
0.000001278
bradykinin
-
-
0.0000003 - 0.000191
captopril
0.0569
cyanidin-3-O-sambubioside
-
pH 8.3, 37°C
0.0319
delphinidin-3-O-sambubioside
-
pH 8.3, 37°C
0.00000194
enalaprilat
-
-
0.828
epicatechin
-
pH 8.3, 37°C
0.124
epicatechin dimer
-
pH 8.3, 37°C
0.0047
epicatechin hexamer
-
pH 8.3, 37°C
0.0116
epicatechin pentamer
-
pH 8.3, 37°C
0.0056
epicatechin tetramer
-
pH 8.3, 37°C
0.059
epicatechin trimer
-
pH 8.3, 37°C
0.000083
gluco-aurantioobtusin
-
in 50 mM Tris-HCl buffer (pH 7.5)
0.01148
Gly-Phe-Hyp-Gly-Thr-Hyp-Gly-Leu-Hyp-Gly-Phe
-
37°C, pH 8.3
0.0000001 - 0.00028
lisinopril
0.0000066 - 0.0017
lisW-S
0.0008 - 0.017
LRPARPTSPP
0.0003 - 0.017
LRPARPTSPPA
0.000013
N-(3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-{[3-(biphenyl-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}propanoyl)-L-tryptophan
-
pH and temperature not specified in the publication
0.0000009 - 0.005
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
0.0000024 - 0.0011
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
0.0000018 - 0.0007
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
0.000035 - 0.0026
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
0.0237 - 0.0843
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine
0.0008 - 0.1957
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan
0.043 - 0.3129
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine
0.0133 - 0.3813
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan
0.000005
N-[3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-(biphenyl-4-ylmethyl)propanoyl]-L-tryptophan
-
pH and temperature not specified in the publication
0.000036
N-{(2R)-3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine
-
pH and temperature not specified in the publication
0.00002
N-{(2S)-3-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl}-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tryptophan
-
pH and temperature not specified in the publication
0.0266
noncompetitive inhibitor
-
-
-
0.000002 - 0.00095
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0000085 - 0.0018
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0000025 - 0.004
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.0000014 - 0.00057
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.000084 - 0.025
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
0.00000105
perindoprilat
-
-
0.0000015 - 0.0002
pGlu-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro
0.00003 - 0.01
pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro
0.00008
pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
0.000001 - 0.0001
pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
0.02825
Pro-Arg-Tyr
pH and temperature not specified in the publication
0.00000035
quinaprilat
-
-
0.00000076
ramiprilat
-
-
0.0606
RMLGQTPTK
-
pH 8.5
0.005 - 0.019
Ser-Pro-Pro
0.0024 - 0.2
SSYVHLRPARPTSPP
0.00000057
trandolaprilat
-
-
0.20027
Trp-Gly
pH and temperature not specified in the publication
0.0045
Val-Leu-Ile-Val-Pro
-
-
0.138
Val-Trp
-
pH 8.3, 37°C
0.203
Val-Tyr
-
pH 8.3, 37°C
0.0144
VVYPWTQRF
-
pH 7.5
0.0008 - 0.01
YVHLRPARPTSPP
0.000008 - 0.000018
[CB-TE2A]1--lisinopril
-
0.0003 - 0.0023
[Co-DOTA]1--lisinopril
-
0.00041 - 0.0027
[Co-EDTA]1--lisinopril
-
0.000027 - 0.000189
[Co-GGH]0-lisinopril
0.00000012 - 0.00004
[Co-NTA]0-lisinopril
0.000014 - 0.000028
[Cu-CB-TE2A]1+-lisinopril
-
0.00029 - 0.0018
[Cu-DOTA]1--lisinopril
-
0.00023 - 0.0017
[Cu-EDTA]1--lisinopril
-
0.0001 - 0.0019
[Cu-GGH]0-lisinopril
0.00000033 - 0.000038
[Cu-NTA]0-lisinopril
0.00034 - 0.0022
[DOTA]1--lisinopril
-
0.00014 - 0.00058
[EDTA]3-lisinopril
-
0.000015 - 0.00054
[Fe-CB-TE2A]2+-lisinopril
-
0.00042 - 0.0021
[Fe-DOTA]0-lisinopril
-
0.000016 - 0.00015
[Fe-EDTA]0-lisinopril
-
0.00000024 - 0.000035
[Fe-NTA]1+-lisinopril
0.000029 - 0.000102
[GGH]1+-lisinopril
0.000017 - 0.000023
[Ni-CB-TE2A]1+-lisinopril
-
0.00045 - 0.0026
[Ni-DOTA]1--lisinopril
-
0.00049 - 0.0026
[Ni-EDTA]1--lisinopril
-
0.00011 - 0.001
[Ni-GGH]0-lisinopril
0.00000026 - 0.000033
[Ni-NTA]0-lisinopril
0.00000031 - 0.000057
[NTA]2-lisinopril
0.00009 - 0.0014
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
additional information
additional information
-
0.00000061
(2R)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
C-catalytic domain of ACE, pH 7.5, temperature not specified in the publication
0.00012
(2R)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
C-catalytic domain of ACE, pH 7.5, temperature not specified in the publication
0.00000041
(2S)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
C-catalytic domain of ACE, pH 7.5, temperature not specified in the publication
0.000024
(2S)-2-((3-[hydroxyl (2-phenyl-(1R)-1-([(benzyloxy) carbonyl]-amino)ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl)amino)-3-(4-hydroxy-phenyl) propanoic acid
C-catalytic domain of ACE, pH 7.5, temperature not specified in the publication
0.0000022
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0000024
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0000093
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
pH 7.5, angiotensin-converting enzyme
0.00031
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000015
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.00057
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid
pH 7.5, angiotensin-converting enzyme
0.000014
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.00018
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000013
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.00041
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000015
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.000037
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0002
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.02
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000015
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0000022
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.00049
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.001
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0023
(2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0034
(2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.000016
(2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.00032
(2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0000014
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.0000086
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000069
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.000021
(2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.0000015
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.00003
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.000086
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme 2
0.00049
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
pH 7.5, angiotensin-converting enzyme
0.00081
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
mutant enzyme V379S, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00083
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
wild type enzyme, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.0019
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
mutant enzyme V380T, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.0024
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
mutant enzyme E376D, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.0039
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
mutant enzyme F391Y, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.0181
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-phenylalanine
mutant enzyme V518T, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.000064
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme V379S, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00024
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme E304R, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.000497
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme S516N, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.000618
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme D543E, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.000679
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
wild type enzyme, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00087
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme V379S/V380T, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00087
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme V380T, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00092
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme T282S, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00233
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme E376D, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00475
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme F391Y, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.00974
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenylhexanoyl-L-tryptophan
mutant enzyme V518T, in 50 mM HEPES buffer (pH 6.8) containing 200 mM NaCl, and 0.01 mM ZnCl2, at 25°C
0.0004
(pE)KWAP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.0006
(pE)KWAP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.0007
(pE)KWAP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.0008
(pE)KWAP
-
37°C, pH 7.0, enzyme from testis
0.000003
(pE)WPRPQIPP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.00001
(pE)WPRPQIPP
-
37°C, pH 7.0, enzyme from testis
0.00003
(pE)WPRPQIPP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.0001
(pE)WPRPQIPP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.0018
1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline
inhibition of C-domain
0.0452
1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline
inhibition of N-domain
0.0336
1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline
inhibition of N-domain
0.1435
1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline
inhibition of C-domain
0.000006
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.000065
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH, angiotensin-converting enzyme 2
0.00077
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH, angiotensin-converting enzyme
0.013
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH, angiotensin-converting enzyme
0.0000024
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.000084
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.00075
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
pH 7.5, angiotensin-converting enzyme
0.004
angiotensin II
C-terminal domain of sACE, pH 7.5, temperature not specified in the publication
0.076
angiotensin II
N-terminal domain of sACE, pH 7.5, temperature not specified in the publication
0.0000003
captopril
-
pH 7.5, 25°C
0.0000005
captopril
-
pH 7.5, 37°C, N-domain from lung enzyme
0.0000006
captopril
-
pH 7.5, 37°C, enzyme from lung
0.000009
captopril
-
pH 7.5, 37°C, enzyme from testis
0.000009
captopril
-
pH 8.0, 37°C, N-domain, hydrolysis of o-aminobenzoyl-SDK-(dinitrophenyl)-P-OH
0.00001
captopril
-
pH 8.0, 37°C, wild-type enzyme, hydrolysis of o-aminobenzoyl-SDK-(dinitrophenyl)-P-OH
0.000016
captopril
-
pH 8.0, 37°C, C-domain, hydrolysis of o-aminobenzoyl-FRK-(dinitrophenyl)-P-OH
0.0000165
captopril
-
pH 7.5, 20°C
0.0000166
captopril
pH 7.5, 22°C
0.000025
captopril
-
pH 8.0, 37°C, N-domain, hydrolysis of o-aminobenzoyl-FRK-(dinitrophenyl)-P-OH
0.000046
captopril
-
pH 8.0, 37°C, wild-type enzyme, hydrolysis of o-aminobenzoyl-FRK-(dinitrophenyl)-P-OH
0.000191
captopril
-
pH 8.0, 37°C, C-domain, hydrolysis of o-aminobenzoyl-SDK-(dinitrophenyl)-P-OH
0.0000001
lisinopril
-
-
0.0000001
lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.00000012
lisinopril
-
pH 7.5, 37°C, enzyme from testis
0.00000018
lisinopril
-
pH 7.5, 37°C, enzyme from lung
0.0000002
lisinopril
-
pH 7.5, 37°C, N-domain from lung enzyme
0.00000027
lisinopril
-
-
0.0000006
lisinopril
-
pH 7.5, 25°C
0.000001
lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.0000012
lisinopril
pH 6.8, 25°C, recombinant testis ACE C-domain
0.00000126
lisinopril
-
pH 9.5, 37°C
0.00000207
lisinopril
-
-
0.0000048
lisinopril
pH 6.8, 25°C, recombinant testis ACE N-domain
0.00000996
lisinopril
-
-
0.000051
lisinopril
inhibition of C-domain
0.0001315
lisinopril
inhibition of N-domain
0.00028
lisinopril
-
pH 8.3, 37°C
0.0000066
lisW-S
pH 6.8, 25°C, recombinant testis ACE C-domain
0.0017
lisW-S
pH 6.8, 25°C, recombinant testis ACE N-domain
0.0008
LRPARPTSPP
-
37°C, pH 7.0, enzyme from testis
0.0026
LRPARPTSPP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.0032
LRPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.017
LRPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.0003
LRPARPTSPPA
-
37°C, pH 7.0, enzyme from testis
0.0046
LRPARPTSPPA
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.012
LRPARPTSPPA
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.017
LRPARPTSPPA
-
37°C, pH 7.0, recombinant wild-type enzyme
0.0000009
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.0000016
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.0002
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme
0.005
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme
0.0000024
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.0000058
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme 2
0.00062
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme
0.0011
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
pH 7.5, angiotensin-converting enzyme
0.0000018
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0000022
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.00025
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.0007
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.000035
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.000093
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.00086
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0026
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.0237
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine
inhibition of C-domain
0.0843
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine
inhibition of N-domain
0.0008
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan
inhibition of C-domain
0.1957
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan
inhibition of N-domain
0.043
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine
inhibition of N-domain
0.3129
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine
inhibition of C-domain
0.0133
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan
inhibition of N-domain
0.3813
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan
inhibition of C-domain
0.000002
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.00042
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.00084
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.00095
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.0000085
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.00021
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.00055
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0018
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.0000025
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0000071
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0027
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzymepotent and long-acting DPP-IV inhibitor and effective with single daily dosing
0.004
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.0000014
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0000027
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.0000032
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.00057
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.000084
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme 2
0.025
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
pH 7.5, angiotensin-converting enzyme
0.0015
PARPTSPP
-
37°C, pH 7.0, enzyme from testis
0.0021
PARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.0053
PARPTSPP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.049
PARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.0000015
pGlu-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.0000015
pGlu-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.0002
pGlu-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.0002
pGlu-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.00003
pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.00003
pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.008
pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.01
pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.00008
pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.00008
pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.00008
pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.00008
pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.000001
pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.000001
pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.0001
pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.0001
pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.0009
RPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.001
RPARPTSPP
-
37°C, pH 7.0, enzyme from testis
0.0068
RPARPTSPP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.023
RPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.000007
RXP407
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.000007
RXP407
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), N-domain
0.001
RXP407
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ala-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.004
RXP407
-
pH 6.8, 25°C, reaction with (7-methoxycoumarin-2-acetic acid)-Ser-Asp-Lys-(N3-(2,4-dinitrophenyl)-L-2,3-diaminopropyl), C-domain
0.005
Ser-Pro-Pro
-
37°C, pH 7.0, enzyme from testis
0.0069
Ser-Pro-Pro
-
37°C, pH 7.0, recombinant wild-type enzyme
0.013
Ser-Pro-Pro
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.019
Ser-Pro-Pro
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.0024
SSYVHLRPARPTSPP
-
37°C, pH 7.0, enzyme from testis
0.0031
SSYVHLRPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.0077
SSYVHLRPARPTSPP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.2
SSYVHLRPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.0008
YVHLRPARPTSPP
-
37°C, pH 7.0, enzyme from testis
0.002
YVHLRPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional C-domain catalytic site
0.0058
YVHLRPARPTSPP
-
37°C, pH 7.0, recombinant wild-type enzyme
0.01
YVHLRPARPTSPP
-
37°C, pH 7.0, full-length mutant containing only a functional N-domain catalytic site
0.000008
[CB-TE2A]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.000018
[CB-TE2A]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.0003
[Co-DOTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0023
[Co-DOTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00041
[Co-EDTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0027
[Co-EDTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.000027
[Co-GGH]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.000189
[Co-GGH]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.00000012
[Co-NTA]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.00004
[Co-NTA]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.000014
[Cu-CB-TE2A]1+-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.000028
[Cu-CB-TE2A]1+-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00029
[Cu-DOTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0018
[Cu-DOTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00023
[Cu-EDTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0017
[Cu-EDTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.0001
[Cu-GGH]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.0019
[Cu-GGH]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.00000033
[Cu-NTA]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.000038
[Cu-NTA]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.00034
[DOTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0022
[DOTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00014
[EDTA]3-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.00058
[EDTA]3-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.000015
[Fe-CB-TE2A]2+-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.00054
[Fe-CB-TE2A]2+-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00042
[Fe-DOTA]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0021
[Fe-DOTA]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.000016
[Fe-EDTA]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.00015
[Fe-EDTA]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00000024
[Fe-NTA]1+-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.000035
[Fe-NTA]1+-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.000029
[GGH]1+-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.000102
[GGH]1+-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.000017
[Ni-CB-TE2A]1+-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.000023
[Ni-CB-TE2A]1+-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00045
[Ni-DOTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0026
[Ni-DOTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00049
[Ni-EDTA]1--lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
-
0.0026
[Ni-EDTA]1--lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
-
0.00011
[Ni-GGH]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.001
[Ni-GGH]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.00000026
[Ni-NTA]0-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.000033
[Ni-NTA]0-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.00000031
[NTA]2-lisinopril
-
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C
0.000057
[NTA]2-lisinopril
-
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C
0.00009
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
pH 7.5, angiotensin-converting enzyme 2
0.00025
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
pH 7.5, angiotensin-converting enzyme
0.00052
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
pH 7.5, angiotensin-converting enzyme
0.0014
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
pH 7.5, angiotensin-converting enzyme 2
additional information
additional information
inhibition kinetics
-
additional information
additional information
inhibition kinetics of point exchange mutants with lisinopril and lisW-S, the mutants show highly decreased Ki for inhibitor lisW-S with their N-domain, overview
-
additional information
additional information
-
inhibition kinetics of point exchange mutants with lisinopril and lisW-S, the mutants show highly decreased Ki for inhibitor lisW-S with their N-domain, overview
-