Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Cl- | activates | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Chinese hamster ovary cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | - |
Homo sapiens | |
EDTA | recombinant enzyme, restored by ZnSO4 | Homo sapiens | |
enaprilat | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
angiotensin I | recombinant enzyme | Homo sapiens | |
0.136 | - |
2-furanacryloyl-Phe-Gly-Gly | wild-type enzyme | Homo sapiens | |
0.174 | - |
2-furanacryloyl-Phe-Gly-Gly | recombinant enzyme | Homo sapiens | |
1.54 | - |
hippuryl-His-Leu | recombinant enzyme | Homo sapiens | |
1.61 | - |
hippuryl-His-Leu | wild-type enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | anchored to the plasma membrane by the C-terminal transmembrane domain | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
170000 | - |
x * 170000, kidney enzyme, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the secreted form is derived from the membrane-bound form by a post-translational proteolytic cleavage of the C-terminal region | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-furanacryloyl-Phe-Gly-Gly + H2O | - |
Homo sapiens | 2-furanacryloyl-Phe + Gly-Gly | - |
? | |
angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
Substance P + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 170000, kidney enzyme, SDS-PAGE | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21.3 | - |
Substance P | free acid, recombinant enzyme, and wild-type enzyme | Homo sapiens | |
320 | - |
2-furanacryloyl-Phe-Gly-Gly | recombinant enzyme | Homo sapiens | |
368 | - |
2-furanacryloyl-Phe-Gly-Gly | wild-type enzyme | Homo sapiens | |
408 | - |
hippuryl-His-Leu | recombinant enzyme | Homo sapiens | |
414 | - |
hippuryl-His-Leu | wild-type enzyme | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
recombinant and wild-type enzyme | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9 | pH 7.5: about 40% of maximal activity, pH 9.0: about 75% of maximal activity | Homo sapiens |