3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.15 Peptidyl-dipeptidases

                3.4.15.1 peptidyl-dipeptidase A

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Results	in table
30	Activating Compound
189	AA Sequence
65	Application
1	CAS Registry Number
25	Cloned(Commentary)
12	Crystallization (Commentary)
65670	Disease/ Diagnostics
2	Expression
54	General Information
3	General Stability
411	IC50 Value
1153	Inhibitors
1	kcat/KM [mM/s]
307	Ki Value [mM]
249	KM Value [mM]
51	Localization
68	Metals/Ions
81	Molecular Weight [Da]
98	Natural Substrates/ Products (Substrates)
739	Organism
132	PDB ID
54	pH Optimum
8	pH Range
3	pH Stability
3	pI Value
49	Posttranslational Modification
39	Protein Variants
51	Purification (Commentary)
1	Reaction
1	Reaction Type
407	Reference
429	Source Tissue
45	Specific Activity [micromol/min/mg]
6	Storage Stability
535	Substrates and Products (Substrate)
56	Subunits
338	Synonyms
37	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
172	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 3.4.15.1 - peptidyl-dipeptidase A

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-20°C, 1 mg/ml enzyme in phosphate buffer, stable for 2 months

Homo sapiens

-

81240

-20°C, 1 mg/ml enzyme, stable for several months

Homo sapiens

-

81225

-20°C, 90% loss of activity after 1 month

Bos taurus

-

650267

-20°C, pH 7.0, 0.01 M KH2PO4/K2HPO4, 0.5 M NaCl, stable for several months

Homo sapiens

-

81213

4°C, pH 7.2, in presence of 10% glycerol, activity remains unchanged for at least 3 months

Bos taurus

-

650267

5°C, in dilute solution stable for at least 6 months, in acetone powder extracts stable for 2 years

Oryctolagus cuniculus

-

81214