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Literature summary for 3.4.15.1 extracted from

  • Chattopadhyay, S.; Santhamma, K.R.; Sengupta, S.; McCue, B.; Kinter, M.; Sen, G.C.; Sen, I.
    Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion (2005), J. Biol. Chem., 280, 33847-33855.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
S730A cleavage secretion of the mutant angiotensin-converting enzyme remains susceptible to the enhancing effect of phorbol 12-myristate 13-acetate and calmodulin inhibitor CaMI Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
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 Oryctolagus cuniculus
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-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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 expressed in a mouse epithelial cell line or in HeLa cells permanently transfected with gACE expression vector
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein tyrosine phosphorylation of the ectodomain of ACE regulates the cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme. ACE is also phosphorylated at Ser730 of the cytoplasmic domain. Phorbol 12-myristate 13-acetate and calmodulin inhibitor CaMI can enhance both cleavage secretion of ACE and its dephosphorylation Oryctolagus cuniculus

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus