3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.15 Peptidyl-dipeptidases

                3.4.15.1 peptidyl-dipeptidase A

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Results	in table
30	Activating Compound
189	AA Sequence
65	Application
1	CAS Registry Number
25	Cloned(Commentary)
12	Crystallization (Commentary)
65670	Disease/ Diagnostics
2	Expression
54	General Information
3	General Stability
411	IC50 Value
1153	Inhibitors
1	kcat/KM [mM/s]
307	Ki Value [mM]
249	KM Value [mM]
51	Localization
68	Metals/Ions
81	Molecular Weight [Da]
98	Natural Substrates/ Products (Substrates)
739	Organism
132	PDB ID
54	pH Optimum
8	pH Range
3	pH Stability
3	pI Value
49	Posttranslational Modification
39	Protein Variants
51	Purification (Commentary)
1	Reaction
1	Reaction Type
407	Reference
429	Source Tissue
45	Specific Activity [micromol/min/mg]
6	Storage Stability
535	Substrates and Products (Substrate)
56	Subunits
338	Synonyms
37	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
172	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.15.1 - peptidyl-dipeptidase A

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

35

Struthio camelus australis

A0A093HJH8

purified native enzyme, 30 min, completely stable up to

755273

37

Pseudomonas sp.

-

stable for at least 30 min

81286

40

Homo sapiens

-

15 min, crude seminal plasma, stable

81250

45

3 entries

50

2 entries

55

4 entries

60

3 entries

70

Homo sapiens

-

15 min, complete inactivation

81250

additional information

Rattus norvegicus

-

chelators and Co2+ markedly potentiate the thermal denaturation

81254

45

Bacillus pumilus

-

stable below

81285

45

Homo sapiens

-

5-30 min, stable

81242

45

Sus scrofa

-

relatively stable below, with or without Cl-

81264

50

Homo sapiens

-

10 min, 60% loss of activity

81242

50

Homo sapiens

-

10 min, enzyme form I and II lose 90% of the hydrolytic activity with hippuryl-His-Leu as substrate, enzyme form III loses 45% of its activity

81246

55

Homo sapiens

-

10 min, 80% loss of activity

81242

55

Rattus norvegicus

-

lung enzyme looses 50% of the activity after 1.5 min, testicular enzyme looses 50% loss of activity

81254

55

Struthio camelus

-

90% activity for 30 min

732845

55

Struthio camelus australis

A0A093HJH8

purified native enzyme, 30 min, 90% activity reamining

755273

60

Homo sapiens

-

15 min, crude seminal plasma, stable

81250

60

Struthio camelus

-

complete inactivation

732845

60

Struthio camelus australis

A0A093HJH8

purified native enzyme, 30 min, inactivation

755273