3.4.15.1: peptidyl-dipeptidase A

This is an abbreviated version!
For detailed information about peptidyl-dipeptidase A, go to the full flat file.

Reaction

release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II =

Synonyms

ACE, ACE-1, ACE2, ACEI, ANCE, ANG I-converting enzyme, angiotensin 1 converting enzyme, angiotensin converting enzyme, angiotensin converting enzyme 1, angiotensin converting enzyme I, angiotensin converting enzyme inhibitor, angiotensin I converting enzyme, angiotensin I-converting enzyme, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme type 1, angiotensin-converting enzyme-2, angiotensin-converting-enzyme, angiotensin-I converting enzyme, angiotensin-I-converting enzyme, carboxycathepsin, carboxypeptidase, dipeptidyl, CD143, CD143 antigen, crab-ACE, DCP, Dcp1, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase I, dipeptidylcarboxypeptidase, endothelial cell peptidyl dipeptidase, gACE, germinal ACE, kinases II peptidyldipeptide hydrolase, kininase II, mACE2, More, PDH, peptidase P, peptidyl dipeptidase, peptidyl dipeptidase A, peptidyl dipeptidase I, peptidyl dipeptidase-4, peptidyl dipeptide hydrolase, peptidyl-dipeptide hydrolase, peptidyldipeptide hydrolase, rhACE2, s-ACE, sACE, sACE-1, somatic ACE, somatic angiotensin I-converting enzyme, TACE, testicular ACE, testis ACE, XcACE, zinc dipeptidyl carboxypeptidase, Zn2+ peptidyldipeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.15 Peptidyl-dipeptidases

                3.4.15.1 peptidyl-dipeptidase A

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
30	Activating Compound
189	AA Sequence
65	Application
1	CAS Registry Number
25	Cloned(Commentary)
12	Crystallization (Commentary)
65670	Disease/ Diagnostics
2	Expression
54	General Information
3	General Stability
411	IC50 Value
1153	Inhibitors
1	kcat/KM [mM/s]
307	Ki Value [mM]
249	KM Value [mM]
51	Localization
68	Metals/Ions
81	Molecular Weight [Da]
98	Natural Substrates/ Products (Substrates)
739	Organism
132	PDB ID
54	pH Optimum
8	pH Range
3	pH Stability
3	pI Value
49	Posttranslational Modification
39	Protein Variants
51	Purification (Commentary)
1	Reaction
1	Reaction Type
407	Reference
429	Source Tissue
45	Specific Activity [micromol/min/mg]
6	Storage Stability
535	Substrates and Products (Substrate)
56	Subunits
338	Synonyms
37	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
172	Turnover Number [1/s]

Activating Compound

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Activating Compound on EC 3.4.15.1 - peptidyl-dipeptidase A

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Activating Compound Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

cetyltrimethylammonium bromide

2 entries

Cl-

16 entries

Diazoacetylnorleucine methyl ester

Alitta virens

-

1.0 mM, activation to 115% of control

650873

diisopropylphosphoryl fluoride

Alitta virens

-

1.0 mM, activation to 116.3% of control

650873

PCMB

Bos taurus

-

slight stimulation

81269

SDS

2 entries

Soybean trypsin inhibitor

Alitta virens

-

0.5 mM, activation to 115% of control

650873

-

tosylphenylalanine chloromethyl ketone

Alitta virens

-

1.0 mM, activation to 113% of control

650873

Triton X-100

2 entries

cetyltrimethylammonium bromide

Struthio camelus

-

0.1 and 1 mM

732845

cetyltrimethylammonium bromide

Struthio camelus australis

A0A093HJH8

CTAB, activates at 0.1-1.0 mM

755273

Cl-

Bos taurus

-

activates

650267

Cl-

Bos taurus

-

kcat increases with increasing KCl concentrations, reaches a maximum at about 300 mM KCl, and the begins to decrease. At relatively low concentrations chloride anions activate the C-domain of the enzyme, but at high concentrations chloride inhibits the enzyme activity. Presence of at least two chloride-binding sites in the C-domain of bovine enzyme: binding of chloride to one of the sites causes activation of the enzyme, whereas chloride binding to the second site results in inhibition of the enzymatic activity

667760

Cl-

Gallus gallus

-

activates

81270

Cl-

Homo sapiens

-

-

81241

Cl-

Homo sapiens

-

activates

81212, 81250, 81284

Cl-

Homo sapiens

-

required

81213, 81247

Cl-

Homo sapiens

-

nonessential activator over the pH range 5.0-10.0

81233

Cl-

Homo sapiens

P12821

assay in the presence of zinc and chloride

764572

Cl-

Mammalia

-

required for hydrolysis of angiotensin I, not required for hydrolysis of bradykinin

81241

Cl-

Oryctolagus cuniculus

-

-

81287

Cl-

Oryctolagus cuniculus

-

activates

81214

Cl-

Oryctolagus cuniculus

-

required

81259

Cl-

Rattus norvegicus

-

required

81251

Cl-

Rattus norvegicus

-

activation, optimal NaCl concentration for the brain enzyme in hydrolysis of LVVYPWTQRY is 10 mM, optimal concentration for hydrolysis of angiotensin I is 200 mM

653416

Cl-

Sus scrofa

-

-

81260

Cl-

Sus scrofa

-

activates

81264

SDS

Struthio camelus

-

0.1 mM and 10 mM

732845

SDS

Struthio camelus australis

A0A093HJH8

activates at 0.1 mM

755273

Triton X-100

Struthio camelus

-

0.01%

732845

Triton X-100

Struthio camelus australis

A0A093HJH8

activates at 0.01%, inhibits at 1.0-10.0%

755273