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Literature summary for 3.4.15.1 extracted from
- Pulmonary angiotensin-converting enzyme. Structural and catalytic properties (1975), J. Biol. Chem., 250, 6762-6768.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cl- | required | Oryctolagus cuniculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Bothrops bradykinin potentiating peptides | - |
Oryctolagus cuniculus | |
| EDTA | - |
Oryctolagus cuniculus | |
| Peptide inhibitors | - |
Oryctolagus cuniculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | contains approximately 1 gatom of zinc per mol of enzyme | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 128500 | - |
x * 128500, equilibrium sedimentation under denaturing conditions | Oryctolagus cuniculus |
| 129000 | - |
equilibrium sedimentation under native conditions | Oryctolagus cuniculus |
| 140000 | - |
x * 140000, enzyme from lung, in reduced and denatured state, SDS-PAGE | Oryctolagus cuniculus |
| 300000 | - |
gel filtration | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | glycoprotein | Oryctolagus cuniculus |
| side-chain modification | 26% carbohydrate per weight. The content of sugar residues per mole: 57 galactose, 53 acetylglucosamine, 19 N-acetylneuraminate, 4 fucose | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 89 | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Oryctolagus cuniculus | angiotensin II + His-Leu | - |
? | |
| bradykinin + H2O | - |
Oryctolagus cuniculus | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | Phe-Arg + Ser-Pro -Arg-Pro-Pro-Gly-Phe | ? | |
| hippuryl-His-Leu + H2O | - |
Oryctolagus cuniculus | hippuric acid + His-Leu | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 140000, enzyme from lung, in reduced and denatured state, SDS-PAGE | Oryctolagus cuniculus |
| ? | x * 128500, equilibrium sedimentation under denaturing conditions | Oryctolagus cuniculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 257 | - |
hippuryl-His-Leu | - |
Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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