Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.15.1 extracted from

  • Jaspard, E.; Alhenc-Gelas, F.
    Catalytic properties of the two active sites of angiotensin I-converting enzyme on the cell surface (1995), Biochem. Biophys. Res. Commun., 211, 528-534.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Cl- activates Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutants K361,365 and mutant K961,963, in which one active site has been inactivated by site-directed mutagenesis. Both active centers are catalytically active in the cell membrane-anchored enzyme and convert angiotensin I to angiotensin II Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km values for wild-type and mutant enzymes Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc contains zinc Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
wild-type enzyme and mutants in which one active site has been inactivated by site-directed mutagenesis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-Phe-Arg + H2O
-
Homo sapiens hippuric acid + Phe-Arg
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information Km values for wild-type and mutant enzymes Homo sapiens