3.2.1.166: heparanase
This is an abbreviated version!
For detailed information about heparanase, go to the full flat file.
Word Map on EC 3.2.1.166
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3.2.1.166
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metastasis
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proteoglycans
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angiogenesis
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endothelial
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heparin
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endoglycosidase
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basement
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glycosaminoglycans
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melanoma
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vessel
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oligosaccharide
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platelet
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syndecan-1
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hspgs
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node
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angiogenic
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myeloma
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nephropathy
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anticoagulant
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glycocalyx
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clinicopathological
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metalloproteinases
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glomerular
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procoagulant
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heparin-binding
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antimetastatic
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heparinase
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neovascularization
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fgf-2
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extravasation
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bfgf
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perlecan
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subendothelial
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matrigel
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microvessel
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chondroitin
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pro-tumorigenic
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o-sulfation
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matrix-degrading
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vegf-c
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pharmacology
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glypicans
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diagnostics
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proangiogenic
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medicine
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non-anticoagulant
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iduronic
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sdc1
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prometastatic
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chondroitinase
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intrachain
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drug development
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tfpi-2
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analysis
- 3.2.1.166
- metastasis
- proteoglycans
- angiogenesis
- endothelial
- heparin
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endoglycosidase
-
basement
- glycosaminoglycans
- melanoma
- vessel
- oligosaccharide
- platelet
- syndecan-1
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hspgs
- node
-
angiogenic
- myeloma
- nephropathy
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anticoagulant
-
glycocalyx
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clinicopathological
- metalloproteinases
- glomerular
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procoagulant
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heparin-binding
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antimetastatic
- heparinase
- neovascularization
- fgf-2
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extravasation
- bfgf
- perlecan
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subendothelial
- matrigel
-
microvessel
- chondroitin
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pro-tumorigenic
-
o-sulfation
-
matrix-degrading
- vegf-c
- pharmacology
-
glypicans
- diagnostics
-
proangiogenic
- medicine
-
non-anticoagulant
-
iduronic
- sdc1
-
prometastatic
- chondroitinase
-
intrachain
- drug development
-
tfpi-2
- analysis
Reaction
endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan =
Synonyms
BpHep, C1A heparanase, endo-beta-D-glucuronidase, endo-beta-glucuronidase, heparan sulfate glycosidase, heparanase, heparanase 1, heparanase-1, HPA, Hpa1, Hpa1 heparanase, HPSE, T5
ECTree
3.2.1.166 heparanaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.2.1.166 - heparanase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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heparanase protein is detected primarily within the cytoplasm of the cells, indicating that the enzyme is produced and stored within the cytoplasm of myeloid cells, with limited expression on the cell surface
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overexpression of heparanase in pancreatic adenocarcinomas
elevated levels of heparanasen activity are detected in sera and urine samples of patients suffering from diabetic nephropathy or aggressive metastatic disease
elevated level of heparanase-activity in bone marrow plasma of myeloma patients
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metastatic breast carcinoma cell lines show a substantial increase in hpa gene expression
elevated expression of human heparanase-1 protein occurs in endothelial cells of sprouting capillaries and small vessels in the vicinity of a tumour, but not of mature, quiescent blood vessels
the enzyme penetrates the endothelial layer that lines blood vessels
under normal conditions, heparanase-1 expression is restricted primarily to placental trophoblasts, blood-borne cells and keratinocytes
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heparanase expression in lung cancer samples to understand lung tumor progression and malignancy, overview. Heparanase expression tends to correlate with tumor node metastasis staging in non-small cell lung carcinoma
isolated from trabecular bone specimens of patients with osteoporosis and from healthy subjects
heparanase expression is up-regulated in the synovial fluid and tissue of patients suffering from rheumatoid arthritis, but not in unaffected individuals
elevated level of heparanase-activity is detected in sera and urine samples of patients suffering from diabetic nephropathy or aggressive metastatic disease
additional information
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heparanase protein is mainly detected in neurons. Heparanase transcript and protein reach their greatest levels at early postnatal stages, in particular within the neocortex. At adulthood the increased heparanase transcript level correlates in the hippocampus with enhanced angiogenesis following repeated hypoxia exposures. Potential importance of heparanase in brain homeostasis
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14 adenocarcinomas, 13 squamous cell carcinomas, 5 large cell carcinomas, and 5 small cell carcinomas. All of the tumor types express heparanase, which is predominantly localized within the cytoplasm and nucleus. Squamous cell carcinomas, large cell carcinomas, and small cell carcinomas have a similar subcellular distribution of heparanase to adenocarcinomas but the distribution is less widespread
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activity and expression of the enzyme is modified in cancer tissue compared to control tissue, high expression levels in primary tumors and lymph nodes, detailed overview
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enhanced growth/aggressiveness of numerous cancer cell types following overexpression of heparanase and inhibition of the tumorigenic/metastatic abilities of cancer cells following heparanase gene silencing
heparanase expression is up-regulated in the colon of patients suffering from Crohn's disease and ulcerative colitis
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both the chicken heparanase mRNA and protein are expressed 12 h post fertilization, in cells migrating from the epiblast and forming the hypoblast layer. Later on 72 h, the enzyme is preferentially expressed in cells of the developing vascular and nervous systems
heparanase-1 mRNA and protein are expressed in the liver and colon of 18-week and 22-week human foetuses, but not in the corresponding mature tissues
heparanase induction is found in biopsies of human inflammatory lung disease
heparanase gene expression increases dramatically in myeloma patients following chemotherapy
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increased heparanase expression during NGF-induced neuronal differentiation in PC12 cells
under normal conditions, heparanase-1 expression is restricted primarily to placental trophoblasts, blood-borne cells and keratinocytes
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variant HPSE v1 and v2 mRNA are localised to the cuboidal trophoblast cells of the folded bilayer located nearest to the maternal endometrium. The enzyme likely plays a role in the development and modification of the pig placenta
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heparanase is preferentially expressed by epidermal keratinocytes in human psoriatic lesions
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heparanase occupies regulatory regions of active genes in T cells
additional information
highly expressed in tumors and metastatic cell lines derived from a variety of tissues
additional information
highly metastatic cells and tumours often show elevated expression of heparanase-1 in comparison with their non-invasive counterparts and normal tissues
additional information
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heparanase is up-regulated in essentially all human tumors examined
additional information
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in human cancer cells, when expression of heparanase is enhanced or when tumor cells are exposed to exogenous heparanase, exosome secretion is dramatically increased
additional information
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the enzyme is secreted in invasive cells such as inflammatory cells and highly migratory tumor cells
additional information
heparanase expression is enhanced in almost all cancers examined including various carcinomas, sarcomas and hematological malignancies
additional information
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heparanase expression is enhanced in almost all cancers examined including various carcinomas, sarcomas and hematological malignancies
