Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Astragalus membranaceus extract | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Mus musculus | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ANA-1 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
HPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition decreases the release of IL-1beta and TNF-alpha significantly, but does not change the mRNA levels of IL-1beta and TNF-alpha significantly in Astragalus membranaceus extract-treated macrophages | Mus musculus |
physiological function | the enzyme may be a key regulator of migration and immune response mediator in macrophages. The enzyme is an endo-beta-glucuronidase that cleaves heparan sulfate at specific intra-chain sites, is strongly implicated in dissemination of metastatic tumor cells. When mouse macrophages are stimulated with lipopolysaccharide in the absence or presence of active enzyme, the enzyme strongly sensitizes macrophages activated by lipopolysaccharide in vitro, as indicated by a marked increase in TNF-alpha, IL-6, and IL-12 p35 [5,6]. Furthermore, induction of the enzyme in several inflammatory conditions occurs and is associated with degradation of heparan sulfate, remodeling of the extracellular matrix, facilitating the inflammatory cell migration towards the injury sites and releasing of chemokines anchored within the extracellular matrix network and cell surfaces | Mus musculus |