3.2.1.166: heparanase
This is an abbreviated version!
For detailed information about heparanase, go to the full flat file.
Word Map on EC 3.2.1.166
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3.2.1.166
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metastasis
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proteoglycans
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angiogenesis
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endothelial
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heparin
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endoglycosidase
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basement
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glycosaminoglycans
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melanoma
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vessel
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oligosaccharide
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platelet
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syndecan-1
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hspgs
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node
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angiogenic
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myeloma
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nephropathy
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anticoagulant
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glycocalyx
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clinicopathological
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metalloproteinases
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glomerular
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procoagulant
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heparin-binding
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antimetastatic
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heparinase
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neovascularization
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fgf-2
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extravasation
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bfgf
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perlecan
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subendothelial
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matrigel
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microvessel
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chondroitin
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pro-tumorigenic
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o-sulfation
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matrix-degrading
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vegf-c
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pharmacology
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glypicans
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diagnostics
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proangiogenic
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medicine
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non-anticoagulant
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iduronic
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sdc1
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prometastatic
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chondroitinase
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intrachain
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drug development
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tfpi-2
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analysis
- 3.2.1.166
- metastasis
- proteoglycans
- angiogenesis
- endothelial
- heparin
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endoglycosidase
-
basement
- glycosaminoglycans
- melanoma
- vessel
- oligosaccharide
- platelet
- syndecan-1
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hspgs
- node
-
angiogenic
- myeloma
- nephropathy
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anticoagulant
-
glycocalyx
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clinicopathological
- metalloproteinases
- glomerular
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procoagulant
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heparin-binding
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antimetastatic
- heparinase
- neovascularization
- fgf-2
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extravasation
- bfgf
- perlecan
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subendothelial
- matrigel
-
microvessel
- chondroitin
-
pro-tumorigenic
-
o-sulfation
-
matrix-degrading
- vegf-c
- pharmacology
-
glypicans
- diagnostics
-
proangiogenic
- medicine
-
non-anticoagulant
-
iduronic
- sdc1
-
prometastatic
- chondroitinase
-
intrachain
- drug development
-
tfpi-2
- analysis
Reaction
endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan =
Synonyms
BpHep, C1A heparanase, endo-beta-D-glucuronidase, endo-beta-glucuronidase, heparan sulfate glycosidase, heparanase, heparanase 1, heparanase-1, HPA, Hpa1, Hpa1 heparanase, HPSE, T5
ECTree
3.2.1.166 heparanaseAdvanced search results
results (
results (Engineering
Engineering on EC 3.2.1.166 - heparanase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
E144A
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site-directed mutagenesis, conserved active site residue mutant
E255A
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site-directed mutagenesis, conserved active site residue mutant
additional information
additional information
deletion mutants lacking heparin binding domains (Lys158-Asn162 or Gln270-Lys280) exhibit no enzymatic activity
additional information
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deletion mutants lacking heparin binding domains (Lys158-Asn162 or Gln270-Lys280) exhibit no enzymatic activity
additional information
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generation of Hpa-tg mice in which transgenic heparanase is driven by a constitutive beta-actin promoter in a BALB/c genetic background. The skin of Hpa-tg mice has normal appearance and is characterized by an enhanced hair re-growth, no differences in proliferation of interfollicular keratinocytes between healthy Hpa-tg and wild-type mice. Heparanase overexpression preserves psoriasislike phenotype in mouse skin following multiple 12-O-tetradecanoyl phorbol 12-myristate 13-acetate application
additional information
generation of heparanase-knockout (Hpa-KO) mice, reduced cytokine expression and motility of heparanase-deficient macrophages, phenotype, overview
additional information
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generation of Hpa-tg mice in which transgenic heparanase is driven by a constitutive beta-actin promoter in a BALB/c genetic background. The skin of Hpa-tg mice has normal appearance and is characterized by an enhanced hair re-growth, no differences in proliferation of interfollicular keratinocytes between healthy Hpa-tg and wild-type mice. Heparanase overexpression preserves psoriasislike phenotype in mouse skin following multiple 12-O-tetradecanoyl phorbol 12-myristate 13-acetate application
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additional information
a splice variant of the Spalax enzyme lacking 16 aa encoded by exon 7. This deletion results in a major defect in trafficking and processing of the heparanase protein, leading to a loss of its enzymatic activity
