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Literature summary for 3.2.1.166 extracted from

  • Zhang, Y.; Ryan, D.; Bower, K.; Ilan, N.; Vlodavsky, I.; Laurie, G.
    Focus on molecules: Heparanase (2010), Exp. Eye Res., 91, 476-477.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.166

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
8000
-
 1 * 50000 + 1 * 8000 Homo sapiens
50000
-
 1 * 50000 + 1 * 8000 Homo sapiens
57700
-
 x * 57700, calculated from amino acid sequence Homo sapiens
65000
-
 x * 65000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y251
-
-

Source Tissue

Source Tissue Comment Organism Textmining
choroid
-
 Homo sapiens
-
corneal epithelium
-
 Homo sapiens
-
lacrimal gland
-
 Homo sapiens
-
lens
-
 Homo sapiens
-
retinal pigment epithelium
-
 Homo sapiens
-
saliva
-
 Homo sapiens
-
tear
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparansulfate proteoglycan + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor 2 receptor + H2O
-
 Homo sapiens ?
-
 ?
low density receptor-related protein-1 + H2O
-
 Homo sapiens ?
-
 ?
additional information the enzyme specifically cleaves the glycol-bond between D-glucuronic acid and N-sulfo glucosamine units leaving 4000-5000 Da stubs attached to the core protein Homo sapiens ?
-
 ?
syndecan-1 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 65000, SDS-PAGE Homo sapiens
? x * 57700, calculated from amino acid sequence Homo sapiens
heterodimer 1 * 50000 + 1 * 8000 Homo sapiens

Synonyms

Synonyms Comment Organism
HPSE
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens calculated from amino acid sequence
-
 9.2

Expression

Organism Comment Expression
Homo sapiens heparanase is upregulated in primary human tumors up

General Information

General Information Comment Organism
physiological function heparanase/MAPK1 signaling up regulates MMP9 and uPAR causing temporary loss of cell surface syndecan-1. Heparanase also activates AKT, P38, RAC1, PKC, and Src, thereby stimulating syndecan clustering, cell adhesion and tumorigenicity. Chronically elevated heparanase augments heparan sulfate 6-O-sulfation of syndecan-1, increases affinity for FGF1 and 2, and associates with tumor angiogenesis and metastatic potential Homo sapiens