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Literature summary for 3.2.1.166 extracted from

  • Ramani, V.C.; Yang, Y.; Ren, Y.; Nan, L.; Sanderson, R.D.
    Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity (2011), J. Biol. Chem., 286, 6490-6499.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
CAG cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
HPSE
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Homo sapiens

General Information

General Information Comment Organism
physiological function heparanase plays a dual role in driving hepatocyte growth factor signaling by enhancing hepatocyte growth factor expression and activity. Heparanase mediates enhanced syndecan-1 shedding. Although heparanase enzyme activity is required for enhanced syndecan-1 shedding, the active enzyme is not required for enhanced hepatocyte growth factor synthesis Homo sapiens