Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
15000 | - |
x * 15000, heparanase splice variant T5, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CAG cell | - |
Homo sapiens | - |
Colo-205 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
additional information | not detected in JAR cells | Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
renal cell carcinoma cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 15000, heparanase splice variant T5, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
T5 | enzymatically inactive splice variant of human heparanase, in which 144 bp of intron 5 are joined with exon 4 | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | heparanase variant T5 expression is up-regulated in 75% of human renal cell carcinoma biopsies | up |
General Information | Comment | Organism |
---|---|---|
malfunction | heparanase variant T5 overexpression results in increased cell proliferation and larger colonies in soft agar, mediated by Src activation | Homo sapiens |
physiological function | heparanase variant T5 activates Src and facilitates cell proliferation and enhances myeloma xenograft development | Homo sapiens |