Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
carcinoma cell | - |
Homo sapiens | - |
lymphoblastoid cell line | - |
Homo sapiens | - |
additional information | in human cancer cells, when expression of heparanase is enhanced or when tumor cells are exposed to exogenous heparanase, exosome secretion is dramatically increased | Homo sapiens | - |
myeloma cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression is up-regulated as tumors become more aggressive and is associated with enhanced tumor growth, angiogenesis, and metastasis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzymatically inactive heparanase: mutated heparanase designated M343 fails to stimulate exosome secretion, whereas mutant M225 has a mild stimulatory effect | Homo sapiens |
physiological function | heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. The enzyme expression is up-regulated as tumors become more aggressive and is associated with enhanced tumor growth, angiogenesis, and metastasis. Heparanase enzyme activity is required for robust enhancement of exosome secretion because enzymatically inactive forms of heparanase, even when present in high amounts, do not dramatically increase exosome secretion. Heparanase also impacts exosome protein cargo as reflected by higher levels of syndecan-1, VEGF, and hepatocyte growth factor in exosomes secreted by heparanase-high expressing cells as compared with heparanase-low expressing cells. Exosomes from heparanase-high cells stimulate spreading of tumor cells on fibronectin and invasion of endothelial cells through extracellular matrix better than do exosomes secreted by heparanase-low cells | Homo sapiens |