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Literature summary for 3.2.1.166 extracted from

  • Vlodavsky, I.; Friedmann, Y.; Elkin, M.; Aingorn, H.; Atzmon, R.; Ishai-Michaeli, R.; Bitan, M.; Pappo, O.; Peretz, T.; Michal, I.; Spector, L.; Pecker, I.
    Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis (1999), Nat. Med., 5, 793-802.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of the cloned cDNA in insect and mammalian cells yields 65000 Da and 50000 Da recombinant heparanase proteins. The 50000 Da enzyme represents an N-terminally processed enzyme, at least 100fold more active than the 65000 Da form Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell line metastatic breast carcinoma cell lines show a substantial increase in hpa gene expression Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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MDA-MB-435 cell
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 Homo sapiens
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additional information no expression in MCF-7 cells Homo sapiens
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placenta
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 Homo sapiens
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SK-HEP-1 cell
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 Homo sapiens
-