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3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase

This is an abbreviated version!
For detailed information about 3',5'-cyclic-AMP phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.53

Reaction

adenosine 3',5'-cyclic phosphate
+
H2O
=
AMP

Synonyms

3',5'-cAMP phosphodiesterase, 3',5'-cyclic AMP phosphodiesterase, adenosine 3',5'-cyclic monophosphate PDE, adenosine 3',5'-cyclicmonophosphate-specific PDE, cAMP phosphodiesterase, cAMP phosphodiesterase-4, cAMP-PDE, cAMP-phosphodiesterase, cAMP-phosphodiesterase 1C, cAMP-phosphodiesterase 4D7, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific cyclic nucleotide phosphodiesterase, cAMP-specific PDE, cAMP-specific PDE4A5, cAMP-specific PDE4D2, cAMP-specific phosphodiesterase, cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase 4D11, cAMP-specific phosphodiesterase-4D5, cAMPspecific PDE, class I phosphodiesterase PDEB1, class I phosphodiesterase PDEB2, CpdA, CPDS, cyclic AMP phosphodiesterase type 4, cyclic AMP phosphodiesterase-4, cyclic AMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic nucleotide phosphodiesterase 4, cyclic nucleotide phosphodiesterase 4D, cyclic nucleotide phosphodiesterase-8A, DdPDE4, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, hPDE4A, hPDE4B, HSPDE4A4B, LmjPDEB1, LmjPDEB2, PDE, PDE IVB, PDE-46, PDE-4D3, PDE10A, PDE1C, PDE2, PDE3, PDE4, PDE4A, PDE4A cAMP-specific phosphodiesterase splice variant RD1, PDE4A1, PDE4A10, PDE4A4, PDE4A5, PDE4A8, PDE4B, PDE4B1, PDE4B2, PDE4B3, PDE4B4, PDE4B5, PDE4C, PDE4C2, PDE4D, PDE4D1, PDE4D11, PDE4D3, PDE4D5, PDE4D7, PDE5, PDE7, PDE7A, PDE7A1, PDE7A2, PDE7B, PDE8, PDE8A, PDE8A1, PDE8B, PdeA, PdeB, PDEB1, PdeH, PdeL, phosphodiesterase 4, phosphodiesterase 4 isoform A8, phosphodiesterase 4B, phosphodiesterase 4D, phosphodiesterase 5, phosphodiesterase 7, phosphodiesterase 7B, phosphodiesterase type 4, phosphodiesterase type 5, phosphodiesterase-4, phosphodiesterase-4A5, phosphodiesterase-4B, RegA, RNPDE4A1A, TbPDE1, TbPDE2B, TbrPDEB1, TbrPDEB2, TcPDE1, TcPDE4, TcrPDEA1, TcrPDEB1

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.53 3',5'-cyclic-AMP phosphodiesterase

Molecular Weight

Molecular Weight on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
102500
x * 102500, calculated
125000
x * 125000, SDS-PAGE, recombinant protein
200000
-
gel filtration
29000
31000
34000
-
PdeB, SDS-PAGE
38800
-
x * 39000, SDS-PAGE, x * 38800, deduced from gene sequence, both N-terminally truncated enzyme
39000
-
x * 39000, SDS-PAGE, x * 38800, deduced from gene sequence, both N-terminally truncated enzyme
50000
x * 50000, PDE7A2, calculated from sequence
50100
x * 50100, calculated from sequence
56000
-
gel filtration, sucrose density gradient centrifugation
57000
x * 57000, PDE7A1, calculated from sequence
58000
61000
-
x * 61000, SDS-PAGE
62000
-
unphosphorylated PDE4B4
66000
-
phosphorylated PDE4B4
69000
-
PDE4B2 recombinant protein, SDS-PAGE
79030
calculated from amino acid sequence
83000
x * 83000, SDS-PAGE
87000
-
PDE4B1 or PDE4B3 recombinant protein, SDS-PAGE, the 87000 Da band is termed PDE4B1/B3 due to difficulty of resolving it into separate bands using SDS-PAGE
93000
x * 93000, SDS-PAGE