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Literature summary for 3.1.4.53 extracted from
- Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase (2000), Proc. Natl. Acad. Sci. USA, 97, 472-476.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| PDE7B protein is expressed in a baculovirus expression system | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methylxanthine | - |
Mus musculus |  |
| dipyridamole | - |
Mus musculus | |
| erythro-9-[3-(2-hydroxynonyl)]-adenine | - |
Mus musculus | |
| papaverine | - |
Mus musculus | |
| rolipram | - |
Mus musculus | |
| SCH51866 | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
adenosine 3',5'-cyclic phosphate | - |
Mus musculus | |
| 0.0001 | - |
adenosine 3',5'-cyclic phosphate | PDE7A2 | Mus musculus | |
| 0.0002 | - |
adenosine 3',5'-cyclic phosphate | PDE7A1 | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
x * 50000, PDE7A2, calculated from sequence | Mus musculus |
| 50100 | - |
x * 50100, calculated from sequence | Mus musculus |
| 57000 | - |
x * 57000, PDE7A1, calculated from sequence | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P70453 | - |
- |
| Mus musculus | Q9QXQ1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | PDE7A1 | Mus musculus | - |
| epididymis | - |
Mus musculus | - |
| eye | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| heart | PDE7A2 | Mus musculus | - |
| kidney | PDE7A1 | Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | PDE7A1 | Mus musculus | - |
| lymphoid tissue | PDE7A1 | Mus musculus | - |
| ovary | - |
Mus musculus | - |
| pancreas | most highly expressed in pancreas followed by brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus, and liver | Mus musculus | - |
| pancreas | PDE7A1 | Mus musculus | - |
| placenta | PDE7A1 | Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
| skeletal muscle | PDE7A2 | Mus musculus | - |
| submandibular gland | - |
Mus musculus | - |
| thyroid gland | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine 3',5'-cyclic phosphate + H2O | no activity with cGMP | Mus musculus | adenosine 5'-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50000, PDE7A2, calculated from sequence | Mus musculus |
| ? | x * 50100, calculated from sequence | Mus musculus |
| ? | x * 57000, PDE7A1, calculated from sequence | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE7B | - |
Mus musculus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0021 | - |
- |
Mus musculus | 3-isobutyl-1-methylxanthine | |
| 0.0045 | - |
- |
Mus musculus | 3-isobutyl-1-methylxanthine | |
| 0.009 | - |
- |
Mus musculus | dipyridamole | |
| 0.0125 | - |
- |
Mus musculus | papaverine | |
| 0.022 | - |
- |
Mus musculus | papaverine | |
| 0.035 | - |
- |
Mus musculus | SCH51866 | |
| 0.042 | - |
- |
Mus musculus | dipyridamole | |
| 0.044 | - |
- |
Mus musculus | SCH51866 | |
| 0.13 | - |
- |
Mus musculus | erythro-9-[3-(2-hydroxynonyl)]-adenine | |
| 0.18 | - |
- |
Mus musculus | rolipram | |
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