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0.1195
(-)-6-(3-(3-cyclopropyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
Bos taurus
-
IC50: 0.1195 mM, PDE7
0.31
(2R,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
Homo sapiens
-
IC50: 0.31 mM, PDE4
0.00043
(2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
Homo sapiens
-
IC50: 0.00043 mM, PDE4
0.000085
(4aS,8aR)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0001
1-(2,4-dichlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0011
1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0009
1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0012
1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0024
1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0034
1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0002
1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0006
1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0009
1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.002
1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0012
1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
Cavia porcellus
-
-
0.0023
10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine
Bos taurus
-
-
0.0031
10-[4'-[(b-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
Bos taurus
-
-
0.0044
10-[4'-[(b-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine
Bos taurus
-
-
0.0203 - 0.0453
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide
0.00381 - 3
3-isobutyl-1-methyl-xanthine
0.0021 - 0.698
3-isobutyl-1-methylxanthine
0.0059
3-isobuytl-1-methylxanthine
Homo sapiens
-
0.0087
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Cavia porcellus
-
PDE4
0.00018 - 0.0073
4-[(2-chloro-4-nitrophenyl)thio]-pyridine
0.00057 - 0.0057
4-[8-(3-nitrophenyl)-[1,7]naphthyridin-6-yl]benzoic acid
0.0513 - 0.1008
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
0.0041
apigenin
Homo sapiens
-
-
0.0102
apigenin-7-O-glucoside
Homo sapiens
-
-
0.00002 - 0.000074
apremilast
0.0004 - 0.0097
AWD 12-250
0.000015 - 0.0205
AWD12-281
0.0085
Biochanin A
Cavia porcellus
-
IC50: 0.0085 mM, more selectively inhibits PDE4 than PDE1 or PDE2
0.0002
BRL-50481
Homo sapiens
-
pH and temperature not specified in the publication
19
Caffeine
Leishmania mexicana
-
particulate enzyme
2.401 - 2.91
cAMP-N1-oxide
0.00159 - 0.0262
carboxyamidotriazole
0.0005
CI-1044
Rattus norvegicus
-
pH and temperature not specified in the publication
0.008 - 0.02
Cibacron blue
0.000101 - 0.000114
cilomilast
0.022 - 0.099
Cilostamide
0.0214 - 0.088
cilostazol
0.0000003
cis-(+)-4-(3,4-dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000088
cis-(-)-4-(3,4-dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000004
cis-2-[(E)-4-(1H-imidazol-1-yl)but-2-enyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000052
cis-2-[2-[2-(1H-imidazol-1-yl)ethoxy]ethyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000013
cis-2-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-benzyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000007
cis-2-[4-[(1H-imidazol-1-yl)methyl]benzyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000013
cis-4-(3,4-dimethoxyphenyl)-2-[2-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000014
cis-4-(3,4-dimethoxyphenyl)-2-[3-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.000001
cis-4-(3,4-dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000009
cis-4-(3,4-dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000082
cis-4-(3,4-dimethoxyphenyl)-2-[4-(piperidin-1-ylmethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.000002
cis-4-(3,4-dimethoxyphenyl)-2-[4-[(4-methylpiperazin-1-yl)methyl]benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000009
cis-4-(3,4-dimethoxyphenyl)-2-[4-[(4-oxopiperidin-1-yl)-methyl]benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000097
cis-4-(3,4-dimethoxyphenyl)-2-[4-[(dimethylamino)-methyl]benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000459
cis-5-(3,4-dimethoxyphenyl)-3-[4-(morpholinomethyl)benzyl]-3,4-diazabicyclo[4.1.0]hept-4-en-2-one
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0000164
cis-5-(3,4-dimethoxyphenyl)-3-[4-(morpholinomethyl)benzyl]-3,4-diazabicyclo[4.2.0]oct-4-en-2-one hydrochloride
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.0005
denbufylline
Homo sapiens
-
0.0168
dioclein
Bos taurus
-
isoform PDE4, pH and temperature not specified in the publication
0.0202
diosmetin
Cavia porcellus
-
IC50: 0.0202 mM, PDE4
0.000146 - 0.042
dipyridamole
0.009
dipyridimole
Homo sapiens
-
0.015
E4021
Homo sapiens
-
-
0.128
EHNA
Trypanosoma cruzi
30°C, pH 7.5
0.217
erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride
Trypanosoma cruzi
-
0.13
erythro-9-[3-(2-hydroxynonyl)]-adenine
Mus musculus
-
0.008
ethaverine
Trypanosoma brucei
-
IC50: 0.008 mM
0.000082
ethyl 2-([4-(3-carbamoylpiperazin-1-yl)-6-[4-(dimethylamino)piperidin-1-yl]pyrimidin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.000031
ethyl 2-([4-[(3,4-dimethoxybenzyl)amino]-6-(piperazin-1-yl)pyrimidin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.000076
ethyl 2-([4-[4-(dimethylamino)piperidin-1-yl]-6-(4-hydroxypiperidin-1-yl)pyrimidin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.000083
ethyl 2-([4-[4-(dimethylamino)piperidin-1-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00013
ethyl 2-([4-[4-(dimethylamino)piperidin-1-yl]-6-(morpholin-4-yl)pyrimidin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00012
ethyl 2-([4-[4-(dimethylamino)piperidin-1-yl]-6-[3-(hydroxymethyl)piperidin-1-yl]pyrimidin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00001
ethyl 2-([7-ethyl-6-[(4-sulfamoylbenzyl)amino]-7H-purin-2-yl]amino)-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.000063
ethyl 2-[[4,6-bis(4-hydroxypiperidin-1-yl)pyrimidin-2-yl]amino]-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.000056
ethyl 2-[[4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]-4-methyl-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00027 - 0.00031
ethyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylate
0.017 - 0.019
ethyl 3,5-dimethyl-1-quinolin-8-yl-1H-pyrazole-4-carboxylate
0.015 - 0.019
ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate
0.00088 - 0.0015
ethyl 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxylate
0.06 - 0.082
ethyl 3-methyl-5-(4-methylphenyl)-1H-pyrazole-4-carboxylate
0.000039
ethyl 4-methyl-2-([4-(4-methylpiperazin-1-yl)-6-[methyl(3,4,5-trimethoxybenzyl)amino]pyrimidin-2-yl]amino)-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.0001
ethyl 4-methyl-2-([4-(methylamino)-6-[(4-sulfamoylbenzyl)amino]pyrimidin-2-yl]amino)-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00001
ethyl 4-methyl-2-([4-(piperazin-1-yl)-6-[(4-sulfamoylbenzyl)amino]pyrimidin-2-yl]amino)-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00022
ethyl 4-methyl-2-([4-[(4-sulfamoylbenzyl)amino]pyrimidin-2-yl]amino)-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00001
ethyl 4-methyl-2-([4-[methyl(3,4,5-trimethoxybenzyl)amino]-6-(piperazin-1-yl)pyrimidin-2-yl]amino)-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.000006
ethyl 4-methyl-2-[[4-(piperazin-1-yl)-7-(3,4,5-trimethoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,3-thiazole-5-carboxylate
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.025 - 0.05
ethyl 5-amino-1-(4a,5,6,7,8,9a-hexahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-1H-pyrazole-4-carboxylate
0.0095
genistein
Cavia porcellus
-
IC50: 0.0095 mM, PDE4
0.0282
hesperetin
Cavia porcellus
-
IC50: 0.0282 mM, PDE4
0.0118
hyperoside
Homo sapiens
-
-
0.000085
IR-202
Homo sapiens
-
pH and temperature not specified in the publication
0.0000004 - 0.0000013
L-826,141
0.00421 - 0.00728
LAS-31025
0.043
luteolin-7-glucoside
Cavia porcellus
-
IC50: 0.043 mM, PDB4, dual inhibitionof PDE2 and PDE4
0.0149
luteolin-7-O-glucoside
Homo sapiens
-
-
0.04
methylisobutylxanthine
Rattus norvegicus
-
-
0.0033 - 0.0583
Milrinone
0.0389
myricetin
Cavia porcellus
-
IC50: 0.0389 mM, PDE4
0.105
N-[(5S)-5-[2-(3-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide
Trypanosoma cruzi
30°C, pH 7.5
0.0021
N-[2-(5-chloro-2-nitrophenylthio)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 30°C
0.0000143
N-[3-(1H-imidazol-1-yl)propyl]-2-[cis-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2(1H)-yl]acetamide
Homo sapiens
-
in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C
0.561 - 1.13
N6-monobutyyl-cAMP
0.0125 - 0.174
papaverine
0.0149
patuletin-7-O-glucoside
Homo sapiens
-
-
0.0000002 - 0.0000007
PF-04957325
0.0114
prunetin
Cavia porcellus
-
IC50: 0.0114 mM, PDE4
0.0185
quercetin-3,5,7,3',4'-O-pentaacetate
Cavia porcellus
-
PDE4
0.0051
quercetin-3,5,7,3',4'-O-pentamethylether
Cavia porcellus
-
PDE4
0.0158
quercetin-3,7,4'-O-trimethylether
Cavia porcellus
-
PDE4
0.0039
quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
Cavia porcellus
-
PDE4
0.0285
quercetin-3-O-methylether
Cavia porcellus
-
PDE4
0.34
quinazolinamine
Homo sapiens
-
IC50: 0.34 mM, PDE4
0.000042 - 0.0022
Ro20-1724
0.0000001 - 0.0000006
roflumilast
0.0000016
RP-73401
Homo sapiens
-
IC50: 0.0000016 mM, PDE4
0.000001 - 0.0178
RPR-73401
0.000113 - 0.000117
SB 207499
0.000105 - 0.000109
SCH 351591
0.001 - 0.0861
sildenafil
0.01
tadalafil
Homo sapiens
-
IC50: above 10000 nM, PDE4
0.0025 - 1.958
trequinsin
0.002055 - 0.0046
vardenafil
0.059 - 0.134
vinpocetine
0.01
additional information
Homo sapiens
-
IC 50 for sildenafil and tadalafil is above 10000 nM, PDE7
-
0.0203
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide
Bos taurus
-
IC50: 0.0203 mM, PDE7
0.0453
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide
Bos taurus
-
IC50: 0.0453 mM, PDE4
0.00381
3-isobutyl-1-methyl-xanthine
Mus musculus
pH 7.4, 30°C
0.0322
3-isobutyl-1-methyl-xanthine
Homo sapiens
-
wild-type enzyme
0.175
3-isobutyl-1-methyl-xanthine
Homo sapiens
-
mutant enzyme D440N
2
3-isobutyl-1-methyl-xanthine
Leishmania mexicana
-
soluble enzyme
3
3-isobutyl-1-methyl-xanthine
Leishmania mexicana
-
particulate enzyme
0.0021
3-isobutyl-1-methylxanthine
Mus musculus
-
0.0045
3-isobutyl-1-methylxanthine
Mus musculus
-
0.007
3-isobutyl-1-methylxanthine
Bos taurus
-
IC50: 0.007 mM, PDE7
0.00737
3-isobutyl-1-methylxanthine
Homo sapiens
pH 7.4, 30°C
0.0099
3-isobutyl-1-methylxanthine
Homo sapiens
-
-
0.0658
3-isobutyl-1-methylxanthine
Homo sapiens
mutant enzyme T748A, in 20 mM Tris-HCl, pH 7.5, 4 mM MnCl2, at 24°C
0.1262
3-isobutyl-1-methylxanthine
Trypanosoma cruzi
-
0.304
3-isobutyl-1-methylxanthine
Trypanosoma brucei
-
0.698
3-isobutyl-1-methylxanthine
Homo sapiens
wild type enzyme, in 20 mM Tris-HCl, pH 7.5, 4 mM MnCl2, at 24°C
0.00018
4-[(2-chloro-4-nitrophenyl)thio]-pyridine
Homo sapiens
pH not specified in the publication, 30°C
0.0066
4-[(2-chloro-4-nitrophenyl)thio]-pyridine
Homo sapiens
pH not specified in the publication, 30°C
0.0073
4-[(2-chloro-4-nitrophenyl)thio]-pyridine
Homo sapiens
pH not specified in the publication, 30°C
0.00057
4-[8-(3-nitrophenyl)-[1,7]naphthyridin-6-yl]benzoic acid
Homo sapiens
pH 7.5, 25°C
0.00065
4-[8-(3-nitrophenyl)-[1,7]naphthyridin-6-yl]benzoic acid
Homo sapiens
pH 7.5, 25°C
0.0033
4-[8-(3-nitrophenyl)-[1,7]naphthyridin-6-yl]benzoic acid
Homo sapiens
pH 7.5, 25°C
0.0057
4-[8-(3-nitrophenyl)-[1,7]naphthyridin-6-yl]benzoic acid
Homo sapiens
pH 7.5, 25°C
0.0513
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
Bos taurus
-
IC50: 0.0513 mM, PDE7
0.1008
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
Bos taurus
-
IC50: 0.1008 mM, PDE4
0.00002
apremilast
Homo sapiens
-
recombinant isoform PDE4A4, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication
0.00003
apremilast
Homo sapiens
-
recombinant isoform PDE4D3, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication
0.000049
apremilast
Homo sapiens
-
recombinant isoform PDE4B2, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication
0.00005
apremilast
Homo sapiens
-
recombinant isoform PDE4C2, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication
0.000074
apremilast
Homo sapiens
-
PDE4 purified from U-937 cells, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication
0.0004
AWD 12-250
Homo sapiens
-
mutant enzyme D440N
0.0097
AWD 12-250
Homo sapiens
-
wild-type enzyme
0.000015
AWD12-281
Homo sapiens
-
wild-type enzyme
0.0205
AWD12-281
Homo sapiens
-
mutant enzyme D440N
2.401
cAMP-N1-oxide
Homo sapiens
-
wild-type enzyme
2.91
cAMP-N1-oxide
Homo sapiens
-
mutant enzyme D440N
0.00159
carboxyamidotriazole
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
0.00509
carboxyamidotriazole
Mus musculus
-
enzyme from lung, at pH 8.0 and 30°C
0.00562
carboxyamidotriazole
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.00789
carboxyamidotriazole
Mus musculus
-
enzyme from L1210 cells, at pH 8.0 and 30°C
0.0112
carboxyamidotriazole
Rattus norvegicus
-
enzyme from brain, at pH 8.0 and 30°C
0.0262
carboxyamidotriazole
Mus musculus
-
enzyme from RAW264.7 cells, at pH 8.0 and 30°C
0.008
Cibacron blue
Leishmania mexicana
-
soluble enzyme
0.02
Cibacron blue
Leishmania mexicana
-
particulate enzyme
0.000101
cilomilast
Homo sapiens
-
0.000114
cilomilast
Mus musculus
-
-
0.022
Cilostamide
Bos taurus
-
IC50: 0.022 mM, PDE7
0.0888
Cilostamide
Bos taurus
-
IC50: 0.0888 mM, PDE4
0.099
Cilostamide
Homo sapiens
-
IC50: 0.099 mM, PDE4
0.0214
cilostazol
Bos taurus
-
IC50: 0.0214 mM, PDE7
0.088
cilostazol
Bos taurus
-
IC50: 0.088 mM, PDE4
0.00008
D-22888
Homo sapiens
-
wild-type enzyme
0.0048
D-22888
Homo sapiens
-
mutant enzyme D440N
0.0094
diazepam
Mus musculus
-
0.043
diazepam
Mus musculus
-
0.000146
dipyridamole
Trypanosoma cruzi
-
0.00051
dipyridamole
Mus musculus
pH 7.4, 30°C
0.0011
dipyridamole
Homo sapiens
-
-
0.00113
dipyridamole
Trypanosoma cruzi
pH 7.5, 30°C
0.00194
dipyridamole
Homo sapiens
pH 7.4, 30°C
0.0045
dipyridamole
Mus musculus
-
0.009
dipyridamole
Mus musculus
-
0.0113
dipyridamole
Trypanosoma cruzi
30°C, pH 7.5
0.013
dipyridamole
Trypanosoma brucei
-
IC50: 0.013 mM
0.015
dipyridamole
Trypanosoma cruzi
30°C, pH 7.5
0.017
dipyridamole
Trypanosoma cruzi
-
0.027
dipyridamole
Trypanosoma brucei
-
0.042
dipyridamole
Mus musculus
-
0.0013
etazolate
Trypanosoma cruzi
-
0.025
etazolate
Trypanosoma brucei
-
IC50: 0.025 mM
0.127
etazolate
Trypanosoma brucei
-
1.3
etazolate
Trypanosoma cruzi
IC50: 1.3 mM
0.00027
ethyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.00027 mM, PDE4D
0.00031
ethyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.00031 mM, PDE4B
0.017
ethyl 3,5-dimethyl-1-quinolin-8-yl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.017 mM, PDE4B
0.019
ethyl 3,5-dimethyl-1-quinolin-8-yl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.019 mM, PDE4D
0.015
ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.015 mM, PDE4B
0.019
ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.019 mM, PDE4D
0.00088
ethyl 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.00088 mM, PDE4D
0.0015
ethyl 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.0015 mM, PDE4B
0.06
ethyl 3-methyl-5-(4-methylphenyl)-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.06 mM, PDE4B
0.082
ethyl 3-methyl-5-(4-methylphenyl)-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.082 mM, PDE4D
0.025
ethyl 5-amino-1-(4a,5,6,7,8,9a-hexahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.025 mM, PDE4B
0.05
ethyl 5-amino-1-(4a,5,6,7,8,9a-hexahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-1H-pyrazole-4-carboxylate
Homo sapiens
-
IC50: 0.05 mM, PDE4D
0.0000004
L-826,141
Rattus norvegicus
-
isozymes PDE4B and PDE4D
0.0000013
L-826,141
Rattus norvegicus
-
isozymes PDE4C and PDE4A
0.00421
LAS-31025
Homo sapiens
-
wild-type enzyme
0.00728
LAS-31025
Homo sapiens
-
mutant enzyme D440N
0.0013
luteolin
Homo sapiens
-
-
0.0191
luteolin
Cavia porcellus
-
IC50: 0.0191 mM, PDE4
0.0033
Milrinone
Homo sapiens
-
mutant enzyme D440N
0.00635
Milrinone
Homo sapiens
-
wild-type enzyme
0.0175
Milrinone
Bos taurus
-
IC50: 0.0175 mM, PDE4
0.0583
Milrinone
Bos taurus
-
IC50: 0.0583 mM, PDE7
0.561
N6-monobutyyl-cAMP
Homo sapiens
-
wild-type enzyme
1.13
N6-monobutyyl-cAMP
Homo sapiens
-
mutant enzyme D440N
0.3
OPC-3911
Leishmania mexicana
-
soluble enzyme
0.8
OPC-3911
Leishmania mexicana
-
particulate enzyme
0.0125
papaverine
Mus musculus
-
0.01288
papaverine
Trypanosoma cruzi
-
0.022
papaverine
Mus musculus
-
0.03
papaverine
Trypanosoma brucei
-
IC50: 0.03 mM
0.111
papaverine
Trypanosoma cruzi
-
0.127
papaverine
Trypanosoma brucei
-
0.174
papaverine
Mus musculus
-
0.0000002
PF-04957325
Mus musculus
-
PDE8B, pH and temperature not specified in the publication
0.0000007
PF-04957325
Mus musculus
-
PDE8A, pH and temperature not specified in the publication
0.0099
quercetin
Cavia porcellus
-
IC50: 0.0099 mM, PDE4
0.0099
quercetin
Cavia porcellus
-
PDE4
0.000042
Ro20-1724
Homo sapiens
-
0.002
Ro20-1724
Rattus norvegicus
-
-
0.0022
Ro20-1724
Homo sapiens
-
0.0000001
roflumilast
Rattus norvegicus
-
isozymes PDE4A, PDE4B, and PDE4D
0.0000006
roflumilast
Rattus norvegicus
-
isozyme PDE4C
0.00001
rolipram
Homo sapiens
-
in 20 mM Tris-HCl at pH 7.4, 10 mM MgCl2, and 0.1 mM EDTA, at 30°C
0.000011
rolipram
Homo sapiens
-
0.0000131
rolipram
Mus musculus
-
enzyme from lung, at pH 8.0 and 30°C
0.0000149
rolipram
Mus musculus
-
enzyme from RAW264.7 cells, at pH 8.0 and 30°C
0.0000188
rolipram
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.000021
rolipram
Homo sapiens
-
0.00005
rolipram
Homo sapiens
-
-
0.000083
rolipram
Rattus norvegicus
-
0.0000943
rolipram
Rattus norvegicus
-
enzyme from brain, at pH 8.0 and 30°C
0.0000945
rolipram
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
0.0001
rolipram
Cavia porcellus
-
-
0.000143
rolipram
Rattus norvegicus
-
0.000148
rolipram
Homo sapiens
-
0.000149
rolipram
Homo sapiens
-
mutant enzyme A590C
0.00017
rolipram
Mus musculus
-
0.000181
rolipram
Homo sapiens
-
wild-type enzyme
0.0002
rolipram
Homo sapiens
-
mutant enzyme L391A
0.000202
rolipram
Homo sapiens
-
mutant enzyme W375Y
0.000256
rolipram
Homo sapiens
-
mutant enzyme V501A
0.000293
rolipram
Homo sapiens
-
mutant enzyme W605F
0.00032
rolipram
Homo sapiens
-
mutant enzyme F484Y
0.00038
rolipram
Mus musculus
-
-
0.0004
rolipram
Rattus norvegicus
-
-
0.00045
rolipram
Bos taurus
-
IC50: 0.00045 mM, PDE4
0.0007
rolipram
Bos taurus
-
isoform PDE4, pH and temperature not specified in the publication
0.001
rolipram
Rattus norvegicus
-
-
0.0011
rolipram
Mus musculus
-
0.0023
rolipram
Cavia porcellus
-
PDE4
0.00245
rolipram
Homo sapiens
-
mutant enzyme P595I
0.01046
rolipram
Trypanosoma cruzi
-
0.04265
rolipram
Homo sapiens
-
mutant enzyme D440A
0.08923
rolipram
Homo sapiens
-
mutant enzyme D440N
0.18
rolipram
Mus musculus
-
0.18
rolipram
Homo sapiens
-
mutant enzyme W375F
0.28
rolipram
Trypanosoma brucei
-
IC50: 0.28 mM
0.6
rolipram
Leishmania mexicana
-
particulate enzyme
0.7
rolipram
Leishmania mexicana
-
soluble enzyme
10.46
rolipram
Trypanosoma cruzi
IC50: 10.46 mM
0.000001
RPR-73401
Homo sapiens
-
wild-type enzyme
0.0178
RPR-73401
Homo sapiens
-
mutant enzyme D440N
0.000113
SB 207499
Homo sapiens
-
0.000117
SB 207499
Rattus norvegicus
-
0.000105
SCH 351591
Homo sapiens
-
0.000109
SCH 351591
Rattus norvegicus
-
0.0015
SCH51866
Homo sapiens
-
PDE7B expressed in transfected COS-7 cells
0.035
SCH51866
Mus musculus
-
0.044
SCH51866
Mus musculus
-
0.001
sildenafil
Trypanosoma brucei
-
IC50: 0.001 mM
0.00319
sildenafil
Homo sapiens
-
IC50: 3190 nM, PDE4
0.0395
sildenafil
Homo sapiens
-
wild-type enzyme
0.0861
sildenafil
Homo sapiens
-
mutant enzyme D440N
3
theophylline
Leishmania mexicana
-
particulate enzyme
30
theophylline
Leishmania mexicana
-
soluble enzyme
0.0025
trequinsin
Trypanosoma brucei
-
IC50: 0.0025 mM
1.958
trequinsin
Trypanosoma cruzi
-
0.002055
vardenafil
Homo sapiens
-
IC50: 2055 nM, PDE4
0.0046
vardenafil
Homo sapiens
-
IC50: 4600 nM, PDE4
0.059
vinpocetine
Homo sapiens
-
-
0.131
vinpocetine
Bos taurus
-
isoform PDE4, pH and temperature not specified in the publication
0.134
vinpocetine
Trypanosoma cruzi
-
0.04
zaprinast
Leishmania mexicana
-
particulate enzyme
0.0525
zaprinast
Homo sapiens
-
mutant enzyme D440N
0.728
zaprinast
Trypanosoma cruzi
-
2.8
zaprinast
Leishmania mexicana
-
soluble enzyme