3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase This is an abbreviated version! For detailed information about 3',5'-cyclic-AMP phosphodiesterase, go to the full flat file .
Reaction
adenosine 3',5'-cyclic phosphate +
H2O =
AMP
Synonyms 3',5'-cAMP phosphodiesterase, 3',5'-cyclic AMP phosphodiesterase, adenosine 3',5'-cyclic monophosphate PDE, adenosine 3',5'-cyclicmonophosphate-specific PDE, cAMP phosphodiesterase, cAMP phosphodiesterase-4, cAMP-PDE, cAMP-phosphodiesterase, cAMP-phosphodiesterase 1C, cAMP-phosphodiesterase 4D7, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific cyclic nucleotide phosphodiesterase, cAMP-specific PDE, cAMP-specific PDE4A5, cAMP-specific PDE4D2, cAMP-specific phosphodiesterase, cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase 4D11, cAMP-specific phosphodiesterase-4D5, cAMPspecific PDE, class I phosphodiesterase PDEB1, class I phosphodiesterase PDEB2, CpdA, CPDS, cyclic AMP phosphodiesterase type 4, cyclic AMP phosphodiesterase-4, cyclic AMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic nucleotide phosphodiesterase 4, cyclic nucleotide phosphodiesterase 4D, cyclic nucleotide phosphodiesterase-8A, DdPDE4, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, hPDE4A, hPDE4B, HSPDE4A4B, LmjPDEB1, LmjPDEB2, PDE, PDE IVB, PDE-46, PDE-4D3, PDE10A, PDE1C, PDE2, PDE3, PDE4, PDE4A, PDE4A cAMP-specific phosphodiesterase splice variant RD1, PDE4A1, PDE4A10, PDE4A4, PDE4A5, PDE4A8, PDE4B, PDE4B1, PDE4B2, PDE4B3, PDE4B4, PDE4B5, PDE4C, PDE4C2, PDE4D, PDE4D1, PDE4D11, PDE4D3, PDE4D5, PDE4D7, PDE5, PDE7, PDE7A, PDE7A1, PDE7A2, PDE7B, PDE8, PDE8A, PDE8A1, PDE8B, PdeA, PdeB, PDEB1, PdeH, PdeL, phosphodiesterase 4, phosphodiesterase 4 isoform A8, phosphodiesterase 4B, phosphodiesterase 4D, phosphodiesterase 5, phosphodiesterase 7, phosphodiesterase 7B, phosphodiesterase type 4, phosphodiesterase type 5, phosphodiesterase-4, phosphodiesterase-4A5, phosphodiesterase-4B, RegA, RNPDE4A1A, TbPDE1, TbPDE2B, TbrPDEB1, TbrPDEB2, TcPDE1, TcPDE4, TcrPDEA1, TcrPDEB1
ECTree
Natural Substrates Products
Natural Substrates Products on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
additional information
?
-
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
DdPDE4 regulates intercellular cAMP during multicellular development
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
the reaction product, 5'-AMP, is further dephosphorylated to adenosine by PdeA and PdeB
-
?
3',5'-cAMP + H2O
5'-AMP
CpdA possesses 3',5'-cAMP phosphodiesterase activity in vitro
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
DdPDE4 is a unique membrane-bound phosphodiesterase with an extracellular catalytic domain regulating intercellular cAMP during multicellular development
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
-
determination of reaction rate and mechanism using computational modeling, quantum mechanical/molecular mechanical-free energy perturbation, QM/MM-FE, and QM/MM-Poisson-Boltzmann surface area, PBSA, calculations. The onQM/MMreaction-coordinate calculations including the protein environment of any PDE-catalyzed reaction system identifies a unique catalytic reaction mechanism, overview
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
-
both PDE8A and 8B hydrolyze cAMP with a very high affinity
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
PDE4B4 isoform may have a distinct functional role in regulating cAMP levels in specific cell types
-
-
?
additional information
?
-
-
isoform PDE4 regulates both GalphaS-dependent and GalphaS-indeoendent cAMP pools in the neurons controling locomotion rate
-
-
?
additional information
?
-
-
PDE4 may be involved in the cyclic nucleotide-mediated control of smooth muscle tone
-
-
?
additional information
?
-
-
enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell
-
-
?
additional information
?
-
-
interaction of PDE4D5 with both the N- and C-domains of beta-arrestin 2 are essential for beta2-adrenoceptor regulation
-
-
?
additional information
?
-
interaction of PDE4D5 with both the N- and C-domains of beta-arrestin 2 are essential for beta2-adrenoceptor regulation
-
-
?
additional information
?
-
PDE4D deficiency may contribute to heart failure and arrhythmias by promoting defective regulation of the RyR2 channel in humans
-
-
?
additional information
?
-
PDE4D deficiency may contribute to heart failure and arrhythmias by promoting defective regulation of the RyR2 channel in humans
-
-
?
additional information
?
-
PDE4D deficiency may contribute to heart failure and arrhythmias by promoting defective regulation of the RyR2 channel in humans
-
-
?
additional information
?
-
-
PDE4D5 plays a nonredundant and functionally significant role in its interaction with beta-arrestin and in the mechanics of beta2-adrenergic receptor signalling
-
-
?
additional information
?
-
-
protein-protein interactions between EPAC1 and PDE4D, peptide mapping for binding site determination. A cell-permeable variant of this peptide antagonizes EPAC1-PDE4D binding and directly alters vascular endothelial cell permeability
-
-
?
additional information
?
-
-
recruitment of PDE4 to the beta2 adrenergic receptor
-
-
?
additional information
?
-
-
PDE4 is a component of signaling pathways involved in the mediation of antidepressant activity
-
-
?
additional information
?
-
-
PDE4B is involved in LPS signaling
-
-
?
additional information
?
-
-
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase
-
-
?
additional information
?
-
-
PDE4 regulates adenosine A2A receptor signaling in striatopallidal neurons
-
-
?
additional information
?
-
-
Myxococcus xanthus PdeA and PdeB, enzymes hydrolyze 3',5'- and 2',3'-cyclic AMP to adenosine, and also demonstrate phosphatase activity toward nucleoside 5'-tri-, 5'-di-, 5'- and 3'-monophosphates with highest activities for nucleoside 5'-monophosphates. PdeA and PdeB also show high phosphomonoesterase activities against 50-UMP, 3'-AMP, and 3'-GMP, low activities against 5'-dAMP, and no activities toward 2'-AMP and 2'-GMP
-
-
?
additional information
?
-
iron and conserved residues are essential for CpdA activity, the catalytic mechanism for Pseudomonas aeruginosa CpdA utilizes a Fe3+-Fe2+ center
-
-
?
additional information
?
-
-
iron and conserved residues are essential for CpdA activity, the catalytic mechanism for Pseudomonas aeruginosa CpdA utilizes a Fe3+-Fe2+ center
-
-
?
additional information
?
-
-
during development PDE4 is the major PDE
-
-
?
additional information
?
-
-
almost all the PDE4D isoforms, known as the main cAMP-regulated rolipramsensitive PDE in Sertoli cells, are expressed throughout the early postpartum period, whereas only the short PDE4D isoforms (PDE4D1 and PDE4D2) are transcriptionally regulated by FSH
-
-
?
additional information
?
-
-
increased PDE4 activity, specifically phosphodiesterase 4B4 activity, reduces beta-adrenergic signaling in the kidney and contributes to salt-sensitive hypertension in the Dahl salt-sensitive rat
-
-
?
additional information
?
-
-
TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs
-
-
?
additional information
?
-
TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs
-
-
?
additional information
?
-
TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs
-
-
?
additional information
?
-
TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs
-
-
?