3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase
This is an abbreviated version!
For detailed information about 3',5'-cyclic-AMP phosphodiesterase, go to the full flat file.
Word Map on EC 3.1.4.53
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3.1.4.53
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rolipram
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pulmonary
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phosphodiesterases
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roflumilast
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asthma
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airway
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cyclase
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pka
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psoriasis
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agonist
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apremilast
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inhale
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tnf
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camp-dependent
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atopic
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dermatitis
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corticosteroid
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cgmp
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forskolin
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bronchodilator
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adenylyl
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eosinophil
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nausea
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bronchoalveolar
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emesis
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long-acting
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theophylline
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camp-pde
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salbutamol
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ointment
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ibmx
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pruritus
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cilostamide
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moderate-to-severe
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milrinone
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bronchoconstriction
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camp-mediated
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zaprinast
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medicine
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salmeterol
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pcreb
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beta2ars
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beta2-adrenoceptors
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labas
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camp-elevating
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beta2-agonists
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pde10a
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cgmp-specific
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molecular biology
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akaps
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tofacitinib
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ustekinumab
- 3.1.4.53
- rolipram
- pulmonary
- phosphodiesterases
- roflumilast
- asthma
- airway
- cyclase
- pka
- psoriasis
- agonist
- apremilast
-
inhale
- tnf
-
camp-dependent
-
atopic
- dermatitis
-
corticosteroid
- cgmp
- forskolin
-
bronchodilator
-
adenylyl
-
eosinophil
-
nausea
-
bronchoalveolar
- emesis
-
long-acting
- theophylline
- camp-pde
- salbutamol
-
ointment
- ibmx
- pruritus
- cilostamide
-
moderate-to-severe
- milrinone
-
bronchoconstriction
-
camp-mediated
- zaprinast
- medicine
- salmeterol
-
pcreb
-
beta2ars
-
beta2-adrenoceptors
-
labas
-
camp-elevating
-
beta2-agonists
- pde10a
-
cgmp-specific
- molecular biology
-
akaps
-
tofacitinib
-
ustekinumab
Reaction
Synonyms
3',5'-cAMP phosphodiesterase, 3',5'-cyclic AMP phosphodiesterase, adenosine 3',5'-cyclic monophosphate PDE, adenosine 3',5'-cyclicmonophosphate-specific PDE, cAMP phosphodiesterase, cAMP phosphodiesterase-4, cAMP-PDE, cAMP-phosphodiesterase, cAMP-phosphodiesterase 1C, cAMP-phosphodiesterase 4D7, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific cyclic nucleotide phosphodiesterase, cAMP-specific PDE, cAMP-specific PDE4A5, cAMP-specific PDE4D2, cAMP-specific phosphodiesterase, cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase 4D11, cAMP-specific phosphodiesterase-4D5, cAMPspecific PDE, class I phosphodiesterase PDEB1, class I phosphodiesterase PDEB2, CpdA, CPDS, cyclic AMP phosphodiesterase type 4, cyclic AMP phosphodiesterase-4, cyclic AMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic nucleotide phosphodiesterase 4, cyclic nucleotide phosphodiesterase 4D, cyclic nucleotide phosphodiesterase-8A, DdPDE4, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, hPDE4A, hPDE4B, HSPDE4A4B, LmjPDEB1, LmjPDEB2, PDE, PDE IVB, PDE-46, PDE-4D3, PDE10A, PDE1C, PDE2, PDE3, PDE4, PDE4A, PDE4A cAMP-specific phosphodiesterase splice variant RD1, PDE4A1, PDE4A10, PDE4A4, PDE4A5, PDE4A8, PDE4B, PDE4B1, PDE4B2, PDE4B3, PDE4B4, PDE4B5, PDE4C, PDE4C2, PDE4D, PDE4D1, PDE4D11, PDE4D3, PDE4D5, PDE4D7, PDE5, PDE7, PDE7A, PDE7A1, PDE7A2, PDE7B, PDE8, PDE8A, PDE8A1, PDE8B, PdeA, PdeB, PDEB1, PdeH, PdeL, phosphodiesterase 4, phosphodiesterase 4 isoform A8, phosphodiesterase 4B, phosphodiesterase 4D, phosphodiesterase 5, phosphodiesterase 7, phosphodiesterase 7B, phosphodiesterase type 4, phosphodiesterase type 5, phosphodiesterase-4, phosphodiesterase-4A5, phosphodiesterase-4B, RegA, RNPDE4A1A, TbPDE1, TbPDE2B, TbrPDEB1, TbrPDEB2, TcPDE1, TcPDE4, TcrPDEA1, TcrPDEB1
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3.1.4.53 3',5'-cyclic-AMP phosphodiesteraseAdvanced search results
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results (Localization
Localization on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
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colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region
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the enzyme is secreted by the plasmodium during migration
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PDE4 (56%) and PDE3 (44%) are the main cyclic phosphodiesterase activities in cardiac nuclei
additional information
TbrPDEB2 is distributed between flagellum and cytoplasm
predominant localization, recombinant protein expressed in COS-7 cell
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the enzyme associated with both the soluble and particulate fractions
when expressed in COS-7 cells, PDE4A8 localizes predominantly in the cytosol, but 20% of the enzyme is associated with membrane fractions
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with the exception of one isoform PDE4A, PDE4 enzymes are primarily cytosolic enzymes
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PDE4B5 is distributed predominantly and unevenly within the cytosol
a fully functional GFP-tagged PdeH is cytosolic but associates dynamically with the plasma membrane and vesicular compartments
TbrPDEB2 is distributed between flagellum and cytoplasm
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colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region
PDE4A splice variant RD1 contains a membrane-association signal which allows the targeted expression of RD1 within the Golgi complex of human follicular thyroid carcinoma cell lines FTC133 and FTC236
membrane-bound enzyme with an extracellular domain
DdPDE4 is a unique membrane-bound phosphodiesterase with an extracellular catalytic domain regulating intercellular cAMP during multicellular development
about 20% of protein is associated with membrane, recombinant protein expressed in COS-7 cell
when expressed in COS-7 cells, PDE4A8 localizes predominantly in the cytosol, but 20% of the enzyme is associated with membrane fractions
helix-1 is important for intracellular targeting of PDE4A1 in living cells, facilitating membrane association, targeting to the trans-Golgi stack and conferring Ca2+-stimulated intracellular redistribution in a manner that is dependent on the phospholipase-D-mediated generation of phosphatidic acid
small part of enzyme is associated with the plasma membrane
additional information
the deletion mutant the GFP-PdeL localizes predominantly to the nucleus
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additional information
the deletion mutant the GFP-PdeL localizes predominantly to the nucleus
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additional information
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the soluble PDE4 activities are mainly related to the long PDE4D isoforms and short PDE4D1 is predominantly particulate
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