3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase

This is an abbreviated version!
For detailed information about 3',5'-cyclic-AMP phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.53

3.1.4.53

rolipram

pulmonary

phosphodiesterases

roflumilast

asthma

airway

cyclase

pka

psoriasis

agonist

apremilast

inhale

tnf

camp-dependent

atopic

dermatitis

corticosteroid

cgmp

forskolin

bronchodilator

adenylyl

eosinophil

nausea

bronchoalveolar

emesis

long-acting

theophylline

camp-pde

salbutamol

ointment

ibmx

pruritus

cilostamide

moderate-to-severe

milrinone

bronchoconstriction

camp-mediated

zaprinast

medicine

salmeterol

pcreb

beta2ars

beta2-adrenoceptors

labas

camp-elevating

beta2-agonists

pde10a

cgmp-specific

molecular biology

akaps

tofacitinib

ustekinumab

Reaction

Synonyms

3',5'-cAMP phosphodiesterase, 3',5'-cyclic AMP phosphodiesterase, adenosine 3',5'-cyclic monophosphate PDE, adenosine 3',5'-cyclicmonophosphate-specific PDE, cAMP phosphodiesterase, cAMP phosphodiesterase-4, cAMP-PDE, cAMP-phosphodiesterase, cAMP-phosphodiesterase 1C, cAMP-phosphodiesterase 4D7, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific cyclic nucleotide phosphodiesterase, cAMP-specific PDE, cAMP-specific PDE4A5, cAMP-specific PDE4D2, cAMP-specific phosphodiesterase, cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase 4D11, cAMP-specific phosphodiesterase-4D5, cAMPspecific PDE, class I phosphodiesterase PDEB1, class I phosphodiesterase PDEB2, CpdA, CPDS, cyclic AMP phosphodiesterase type 4, cyclic AMP phosphodiesterase-4, cyclic AMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic nucleotide phosphodiesterase 4, cyclic nucleotide phosphodiesterase 4D, cyclic nucleotide phosphodiesterase-8A, DdPDE4, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, hPDE4A, hPDE4B, HSPDE4A4B, LmjPDEB1, LmjPDEB2, PDE, PDE IVB, PDE-46, PDE-4D3, PDE10A, PDE1C, PDE2, PDE3, PDE4, PDE4A, PDE4A cAMP-specific phosphodiesterase splice variant RD1, PDE4A1, PDE4A10, PDE4A4, PDE4A5, PDE4A8, PDE4B, PDE4B1, PDE4B2, PDE4B3, PDE4B4, PDE4B5, PDE4C, PDE4C2, PDE4D, PDE4D1, PDE4D11, PDE4D3, PDE4D5, PDE4D7, PDE5, PDE7, PDE7A, PDE7A1, PDE7A2, PDE7B, PDE8, PDE8A, PDE8A1, PDE8B, PdeA, PdeB, PDEB1, PdeH, PdeL, phosphodiesterase 4, phosphodiesterase 4 isoform A8, phosphodiesterase 4B, phosphodiesterase 4D, phosphodiesterase 5, phosphodiesterase 7, phosphodiesterase 7B, phosphodiesterase type 4, phosphodiesterase type 5, phosphodiesterase-4, phosphodiesterase-4A5, phosphodiesterase-4B, RegA, RNPDE4A1A, TbPDE1, TbPDE2B, TbrPDEB1, TbrPDEB2, TcPDE1, TcPDE4, TcrPDEA1, TcrPDEB1

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.53 3',5'-cyclic-AMP phosphodiesterase

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Results	in table
14	Activating Compound
4919	AA Sequence
18	Application
1	CAS Registry Number
48	Cloned(Commentary)
10	Crystallization (Commentary)
3586	Disease/ Diagnostics
11	Expression
38	General Information
1	General Stability
266	IC50 Value
356	Inhibitors
2	kcat/KM [mM/s]
31	Ki Value [mM]
59	KM Value [mM]
41	Localization
26	Metals/Ions
25	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
196	Organism
2	Pathway
214	PDB ID
3	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
10	Posttranslational Modification
27	Protein Variants
17	Purification (Commentary)
2	Reaction
159	Reference
2	Renatured (Commentary)
265	Source Tissue
1	Specific Activity [micromol/min/mg]
136	Substrates and Products (Substrate)
18	Subunits
288	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
12	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase

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Calmodulin

Bos taurus

required, Km value 0.000057 mM

cAMP

cGMP

binds to N-terminus and GAF domain, affinity of 0.003 mM

678039

EDTA

Homo sapiens

EDTA at 0.10 mM slightly activates PDE4

690423

extract of Ginkgo biloba

Rattus norvegicus

some beneficial effects of extract of Ginkgo biloba might be due to its modulating influences on cellular cyclic AMP levels via activation of membrane-bound PDE

688524

follicle-stimulating hormone

Rattus norvegicus

stimulation

678559

haloperidol

Rattus norvegicus

chronic treatment with 20 mg/kg clozapine increases PDE4B2 and PDE4B4 expression by 102 and 71%, respectively

694373

isoproterenol

2 entries

additional information

6 entries