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Literature summary for 3.1.4.53 extracted from

  • Dlaboga, D.; Hajjhussein, H.; ODonnell, J.M.
    Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum (2008), Neuropharmacology, 54, 745-754.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
haloperidol chronic treatment with 20 mg/kg clozapine increases PDE4B2 and PDE4B4 expression by 102 and 71%, respectively Rattus norvegicus
additional information PDE4B1, PDE4B2, PDE4B3, and PDE4B4 are not changed by chronic haloperidol treatment Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
membrane
-
Rattus norvegicus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
PDE4B4 recombinant protein, SDS-PAGE Rattus norvegicus
69000
-
PDE4B2 recombinant protein, SDS-PAGE Rattus norvegicus
87000
-
PDE4B1 or PDE4B3 recombinant protein, SDS-PAGE, the 87000 Da band is termed PDE4B1/B3 due to difficulty of resolving it into separate bands using SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
Rattus norvegicus 5'-AMP
-
?

Synonyms

Synonyms Comment Organism
PDE4B
-
Rattus norvegicus
PDE4B1 isozyme Rattus norvegicus
PDE4B2 isozyme Rattus norvegicus
PDE4B3 isozyme Rattus norvegicus
PDE4B4 isozyme Rattus norvegicus
phosphodiesterase-4B
-
Rattus norvegicus