Reference on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lugnier, C.; Keravis, T.; Le Bec, A.; Pauvert, O.; Proteau, S.; Rousseau, E.
Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei
Biochim. Biophys. Acta
1472
431-446
1999
Ovis aries
Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells
FEBS Lett.
324
76-80
1993
Mus musculus
Tanaka, S.; Shimooka, S.; Shimomura, H.
Changes in phosphodiesterase activity in the developing rat submandibular gland
Arch. Oral Biol.
47
567-576
2002
Rattus norvegicus
Sudo, T.; Tachibana, K.; Toga, K.; Tochizawa, S.; Inoue, Y.; Kimura, Y.; Hidaka, H.
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity
Biochem. Pharmacol.
59
347-356
2000
Bos taurus
O'Grady, S.M.; Jiang, X.; Maniak, P.J.; Birmachu, W.; Scribner, L.R.; Bulbulian, B.; Gullikson, G.W.
Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells
J. Membr. Biol.
185
137-144
2002
Homo sapiens
Richter, W.; Hermsdorf, T.; Kronbach, T.; Dettmer, D.
Refolding and Purification of Recombinant Human PDE7A: Expressed in Escherichia coli as Inclusion Bodies
Protein Expr. Purif.
25
138-148
2002
Homo sapiens
Giorgi, M.; Modica, A.; Pompili, A.; Pacitti, C.; Gasbarri, A.
The induction of cyclic nucleotide phosphodiesterase 4 gene (PDE4D) impairs memory in a water maze task
Behav. Brain Res.
154
99-106
2004
Rattus norvegicus
Ko, W.C.; Shih, C.M.; Lai, Y.H.; Chen, J.H.; Huang, H.L.
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships
Biochem. Pharmacol.
68
2087-2094
2004
Cavia porcellus
Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T.
Cyclic nucleotide specific phosphodiesterases of Leishmania major
BMC Microbiol.
6
25
2006
Leishmania major (Q6S996), Leishmania major (Q6S997), Leishmania major
Dlaboga, D.; Hajjhussein, H.; O'Donnell J.M.
Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram
Brain Res.
1096
104-112
2006
Mus musculus
Ahlstrom, M.; Pekkinen, M.; Huttunen, M.; Lamberg-Allardt, C.
Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation
Cell. Mol. Biol. Lett.
10
305-319
2005
Homo sapiens
Kunz, S.; Kloeckner, T.; Essen, L.O.; Seebeck, T.; Boshart, M.
TbPDE1, a novel class I phosphodiesterase of Trypanosoma brucei
Eur. J. Biochem.
271
637-647
2004
Trypanosoma brucei
Bischoff, E.
Potency, selectivity, and consequences of nonselectivity of PDE inhibition
Int. J. Impot. Res.
16
S11-S14
2004
Homo sapiens
Huai, Q.; Liu, Y.; Francis, S.H.; Corbin, J.D.; Ke, H.
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity
J. Biol. Chem.
279
13095-13101
2004
Homo sapiens
Han, P.; Sonati, P.; Rubin, C.; Michaeli, T.
PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C
J. Biol. Chem.
281
15050-15057
2006
Mus musculus
Bader, S.; Kortholt, A.; Snippe, H.; Van Haastert, P.J.
DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells
J. Biol. Chem.
281
20018-20026
2006
Dictyostelium discoideum, Dictyostelium discoideum (Q86H13)
Jin, S.L.; Lan, L.; Zoudilova, M.; Conti, M.
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages
J. Immunol.
175
1523-1531
2005
Mus musculus
Xu, R.X.; Rocque, W.J.; Lambert, M.H.; Vanderwall, D.E.; Luther, M.A.; Nolte, R.T.
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram
J. Mol. Biol.
337
355-365
2004
Homo sapiens
Keravis, T.; Thaseldar-Roumie, R.; Lugnier, C.
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts
Methods Mol. Biol.
307
63-74
2005
Rattus norvegicus
Alonso, G.D.; Schoijet, A.C.; Torres, H.N.; Flawia, M.M.
TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi
Mol. Biochem. Parasitol.
145
40-49
2006
Trypanosoma cruzi, Trypanosoma cruzi (Q4ZHU6)
Card, G.L.; Blasdel, L.; England, B.P.; Zhang, C.; Suzuki, Y.; Gillette, S.; Fong, D.; Ibrahim, P.N.; Artis, D.R.; Bollag, G.; Milburn, M.V.; Kim, S.H.; Schlessinger, J.; Zhang, K.Y.
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
Nat. Biotechnol.
23
201-207
2005
Homo sapiens
Oelke, M.; Hedlund, P.; Albrecht, K.; Ellinghaus, P.; Stief, C.G.; Jonas, U.; Andersson, K.E.; Uckert, S.
Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study
Urology
67
1111-1116
2006
Homo sapiens
Waldkirch, E.; Uckert, S.; Yildirim, H.; Sohn, M.; Jonas, U.; Stief, C.G.; Andersson, K.E.; Hedlund, P.
Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries--immunohistochemical distribution and functional significance
World J. Urol.
23
405-410
2005
Homo sapiens
Murray, F.; Patel, H.H.; Suda, R.Y.; Zhang, S.; Thistlethwaite, P.A.; Yuan, J.X.; Insel, P.A.
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L294-L303
2007
Homo sapiens
Jagadeesh, S.; Padma, T.; Parimala, H.; Chandramouli, K.H.; DSouza, C.J.; Thimmaiah, K.N.
Inhibition of calmodulin-dependent cyclic AMP phosphodiesterase by phenoxazines
Biochem. Biophys. Res. Commun.
342
690-701
2006
Bos taurus
Bolger, G.B.; Baillie, G.S.; Li, X.; Lynch, M.J.; Herzyk, P.; Mohamed, A.; Mitchell, L.H.; McCahill, A.; Hundsrucker, C.; Klussmann, E.; Adams, D.R.; Houslay, M.D.
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
Biochem. J.
398
23-36
2006
Homo sapiens
Diaz-Benjumea, R.; Laxman, S.; Hinds, T.R.; Beavo, J.A.; Rascon, A.
Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi
Biochem. J.
399
305-314
2006
Trypanosoma cruzi, Trypanosoma cruzi (Q49UB9)
Bader, S.; Kortholt, A.; Van Haastert, P.J.
Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP
Biochem. J.
402
153-161
2007
Dictyostelium discoideum
Baillie, G.S.; Adams, D.R.; Bhari, N.; Houslay, T.M.; Vadrevu, S.; Meng, D.; Li, X.; Dunlop, A.; Milligan, G.; Bolger, G.B.; Klussmann, E.; Houslay, M.D.
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays
Biochem. J.
404
71-80
2007
Homo sapiens, Homo sapiens (Q08499)
Wang, H.; Peng, M.S.; Chen, Y.; Geng, J.; Robinson, H.; Houslay, M.D.; Cai, J.; Ke, H.
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
Biochem. J.
408
193-201
2007
Homo sapiens, Homo sapiens (P27815), Homo sapiens (Q08499)
Mackenzie, K.F.; Topping, E.C.; Bugaj-Gaweda, B.; Deng, C.; Cheung, Y.F.; Olsen, A.E.; Stockard, C.R.; Mitchell, L.H.; Baillie, G.S.; Grizzle, W.E.; Devivo, M.; Houslay, M.D.; Wang, D.; Bolger, G.B.
Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change
Biochem. J.
411
361-369
2007
Homo sapiens (P27815), Homo sapiens
Suzuki, H.; Sawanishi, H.; Nomura, M.; Shimada, T.; Miyamoto, K.
Effects of 1-benzylxanthines on cyclic AMP phosphodiesterase 4 isoenzyme
Biol. Pharm. Bull.
29
131-134
2006
Cavia porcellus
Levallet, G.; Levallet, J.; Bouraima-Lelong, H.; Bonnamy, P.J.
Expression of the cAMP-phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells
Biol. Reprod.
76
794-803
2007
Rattus norvegicus
Xiong, Y.; Lu, H.T.; Li, Y.; Yang, G.F.; Zhan, C.G.
Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations
Biophys. J.
91
1858-1867
2006
Homo sapiens
Smith, K.J.; Baillie, G.S.; Hyde, E.I.; Li, X.; Houslay, T.M.; McCahill, A.; Dunlop, A.J.; Bolger, G.B.; Klussmann, E.; Adams, D.R.; Houslay, M.D.
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1
Cell. Signal.
19
2612-2624
2007
Homo sapiens, Homo sapiens (Q08499)
Uckert, S.; Oelke, M.; Stief, C.G.; Andersson, K.E.; Jonas, U.; Hedlund, P.
Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
Eur. Urol.
49
740-745
2006
Homo sapiens
Oberholzer, M.; Marti, G.; Baresic, M.; Kunz, S.; Hemphill, A.; Seebeck, T.
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence
FASEB J.
21
720-731
2007
Trypanosoma brucei, Trypanosoma brucei (Q38F42), Trypanosoma brucei (Q38F46), Trypanosoma brucei (Q8WQX9)
Charlie, N.K.; Thomure, A.M.; Schade, M.A.; Miller, K.G.
The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network
Genetics
173
111-130
2006
Caenorhabditis elegans
Wang, H.; Robinson, H.; Ke, H.
The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10
J. Mol. Biol.
371
302-307
2007
Homo sapiens
Cheung, Y.F.; Kan, Z.; Garrett-Engele, P.; Gall, I.; Murdoch, H.; Baillie, G.S.; Camargo, L.M.; Johnson, J.M.; Houslay, M.D.; Castle, J.C.
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
J. Pharmacol. Exp. Ther.
322
600-609
2007
Mus musculus, Homo sapiens (Q07343), Homo sapiens
Alonso, G.D.; Schoijet, A.C.; Torres, H.N.; Flawia, M.M.
TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi
Mol. Biochem. Parasitol.
152
72-79
2007
Trypanosoma cruzi (Q309F4), Trypanosoma cruzi
Spoto, G.; della Malva, M.; Rubini, C.; Fioroni, M.; Piattelli, A.; Serra, E.; Di Nicola, M.; Santoleri, F.
cAMP phosphodiesterase activity evaluation in human carcinoma of salivary glands
Nucleosides Nucleotides Nucleic Acids
25
1113-1117
2006
Homo sapiens
Narita, M.; Murata, T.; Shimizu, K.; Nakagawa, T.; Sugiyama, T.; Inui, M.; Hiramoto, K.; Tagawa, T.
A role for cyclic nucleotide phosphodiesterase 4 in regulation of the growth of human malignant melanoma cells
Oncol. Rep.
17
1133-1139
2007
Homo sapiens
Brown, D.M.; Hutchison, L.; Donaldson, K.; MacKenzie, S.J.; Dick, C.A.; Stone, V.
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4
Toxicol. Lett.
168
1-6
2007
Homo sapiens, Mus musculus
Fougier, S.; Nemoz, G.; Prigent, A.F.; Marivet, M.; Bourguignon, J.J.; Wermuth, C.; Pacheco, H.
Purification of cAMP-specific phosphodiesterase from rat heart by affinity chromatography on immobilized rolipram
Biochem. Biophys. Res. Commun.
138
205-214
1986
Rattus norvegicus
Fisher, D.A.; Smith, J.F.; Pillar, J.S.; Denis, S.H.St.; Cheng, J.B.
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase
Biochem. Biophys. Res. Commun.
246
570-577
1998
Homo sapiens (O60658), Homo sapiens
Sasaki, T.; Kotera, J.; Yuasa, K.; Omori, K.
Identification of human PDE7B, a cAMP-specific phosphodiesterase
Biochem. Biophys. Res. Commun.
271
575-583
2000
Homo sapiens
Gardner, C.; Robas, N.; Cawkill, D.; Fidock, M.
Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase
Biochem. Biophys. Res. Commun.
272
186-192
2000
Homo sapiens (Q9NP56), Homo sapiens, Mus musculus (Q9QXQ1), Mus musculus
Pooley, L.; Shakur, Y.; Rena, G.; Houslay, M.D.
Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines
Biochem. J.
321 (Pt 1)
177-185
1997
Rattus norvegicus (P54748)
Shepherd, M.; McSorley, T.; Olsen, A.E.; Johnston, L.A.; Thomson, N.C.; Baillie, G.S.; Houslay, M.D.; Bolger, G.B.
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform
Biochem. J.
370
429-438
2003
Rattus norvegicus (P14646)
D'Angelo, M.A.; Sanquineti, S.; Reece, J.M.; Birnbaumer, L.; Torres, H.N.; Flawia, M.M.
Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi
Biochem. J.
378
63-72
2004
Trypanosoma cruzi (Q6XG56), Trypanosoma cruzi
Bian, H.; Zhang, J.; Wu, P.; Lori, A.; Varty, Y.J.; Maywood, T.; Hey, J.A.; Wang, P.
Differential type 4 cAMP-specific phosphodiesterase (PDE4) expression and functional sensitivity to PDE4 inhibitors among rats, monkeys and humans
Biochem. Pharmacol.
68
2229-2236
2004
Rattus norvegicus (P14270), Rattus norvegicus (P14646), Rattus norvegicus (P54748), Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens
Lynch, M.J.; Baillie, G.S.; Houslay, M.D.
cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling
Biochem. Soc. Trans.
35
938-941
2007
Homo sapiens
Kovala, T.; Sanwal, B.D.; Ball, E.H.
Recombinant expression of a type IV, cAMP-specific phosphodiesterase: Characterization and structure-function studies of deletion mutants
Biochemistry
36
2968-2976
1997
Rattus norvegicus
Cherry, J.A.; Thompson, B.E.; Pho, V.
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse
Biochim. Biophys. Acta
1518
27-35
2001
Mus musculus (O89084), Mus musculus (Q9QXI7), Mus musculus
Amegadzie, B.Y.; Hanning, C.R.; McLaughlin, M.M.; Burman, M.; Cieslinski, L.B.; Livi, G.P.; Torphy, T.J.
Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells
Cell Biol. Int.
19
477-484
1995
Homo sapiens
Richter, W.; Unciuleac, L.; Hermsdorf, T.; Kronbach, T.; Dettmer, D.
Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis
Cell. Signal.
13
159-167
2001
Homo sapiens
Houslay, M.D.; Baillie, G.S.; Maurice, D.H.
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
Circ. Res.
100
950-966
2007
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08499), Mus musculus (Q01063)
Horvath, A.; Giatzakis, C.; Tsang, K.; Greene, E.; Osorio, P.; Boikos, S.; Libe, R.; Patronas, Y.; Robinson-White, A.; Remmers, E.; Bertherat, J.; Nesterova, M.; Stratakis, C.A.
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex
Eur. J. Hum. Genet.
16
1245-1253
2008
Homo sapiens, Homo sapiens (O95263), Mus musculus
McLaughlin, M.M.; Cieslinski, L.B.; Burman, M.; Torphy, T.J.; Livi, G.P.
A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA
J. Biol. Chem.
268
6470-6476
1993
Homo sapiens (Q07343), Homo sapiens
Huston, E.; Pooley, L.; Julien, P.; Scotland, G.; McPhee, I.; Sullivan, M.; Bolger, G.; Houslay, M.D.
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram
J. Biol. Chem.
271
31334-31344
1996
Homo sapiens
Bolger, G.B.; Peden, A.H.; Steele, M.R.; MacKenzie, C.; McEwan, D.G.; Wallace, D.A.; Huston, E.; Baillie, G.S.; Houslay, M.D.
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2
J. Biol. Chem.
278
33351-33363
2003
Rattus norvegicus
Huston, E.; Gall, I.; Houslay, T.M.; Houslay, M.D.
Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+
J. Cell Sci.
119
3799-3810
2006
Rattus norvegicus (P54748)
Persani, L.; Borgato, S.; Lania, A.; Filopanti, M.; Mantovani, G.; Conti, M.; Spada, A.
Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations
J. Clin. Endocrinol. Metab.
86
3795-3800
2001
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens
Xin, W.; Tran, T.M.; Richter, W.; Clark, R.B.; Rich, T.C.
Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling
J. Gen. Physiol.
131
349-364
2008
Homo sapiens
Macovschi, O.; Prigent, A.F.; Nemoz, G.; Pacheco, H.
Effects of an extract of Ginkgo biloba on the 3',5'-cyclic AMP phosphodiesterase activity of the brain of normal and triethyltin-intoxicated rats
J. Neurochem.
49
107-114
1987
Rattus norvegicus
Rascon, A.; Viloria, M.E.; De-Chiara, L.; Dubra, M.E.
Characterization of cyclic AMP phosphodiesterases in Leishmania mexicana and purification of a soluble form
Mol. Biochem. Parasitol.
106
283-292
2000
Leishmania mexicana
Yoshida, H.; Beltran-Parrazal, L.; Butler, P.; Conti, M.; Charles, A.C.; Weiner, R.I.
Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
Mol. Endocrinol.
17
1982-1990
2003
Mus musculus
Verghese, M.W.; McConnell, R.T.; Lenhard, J.M.; Hamacher, L.; Jin, S.L.C.
Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isoenzymes in human monocytic cells
Mol. Pharmacol.
47
1164-1171
1995
Homo sapiens
Alvarez, R.; Sette, C.; Yang, D.; Eglen, R.M.; Wilhelm, R.; Shelton, E.R.; Conti, M.
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3
Mol. Pharmacol.
48
616-622
1995
Homo sapiens
Rena, G.; Begg, F.; Ross, A.; Mackenzie, C.; McPhee, I.; Campbell, L.; Huston, E.; Sullivan, M.; Houslay, M.D.
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10
Mol. Pharmacol.
59
996-1011
2001
Homo sapiens
Soderling, S.H.; Bayuga, S.J.; Beavo, J.A.
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
Proc. Natl. Acad. Sci. USA
95
8991-8996
1998
Mus musculus (O88502), Mus musculus
Hetman, J.M.; Soderling, S.H.; Glavas, N.A.; Beavo, J.A.
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase
Proc. Natl. Acad. Sci. USA
97
472-476
2000
Mus musculus (P70453), Mus musculus (Q9QXQ1)
Rascon, A.; Soderling, S.H.; Schaefer, J.B.; Beavo, J.A.
Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei
Proc. Natl. Acad. Sci. USA
99
4714-4719
2002
Trypanosoma brucei (Q9GQU6), Trypanosoma brucei
Zhu, S.; Gan, Z.; Li, Z.; Liu, Y.; Yang, X.; Deng, P.; Xie, Y.; Yu, M.; Liao, H.; Zhao, Y.; Zhao, L.; Liao, F.
The measurement of cyclic nucleotide phosphodiesterase 4 activities via the quantification of inorganic phosphate with malachite green
Anal. Chim. Acta
636
105-110
2009
Homo sapiens
Waddleton, D.; Wu, W.; Feng, Y.; Thompson, C.; Wu, M.; Zhou, Y.P.; Howard, A.; Thornberry, N.; Li, J.; Mancini, J.A.
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets
Biochem. Pharmacol.
76
884-893
2008
Rattus norvegicus
Wang, H.; Yan, Z.; Yang, S.; Cai, J.; Robinson, H.; Ke, H.
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry
47
12760-12768
2008
Homo sapiens (O60658), Homo sapiens
Nanda, K.; Chatterjee, M.; Arya, R.; Mukherjee, S.; Saini, K.S.; Dastidar, S.; Ray, A.
Optimization and validation of a reporter gene assay for screening of phosphodiesterase inhibitors in a high throughput system
Biotechnol. J.
3
1276-1279
2008
Homo sapiens
Herget, S.; Lohse, M.J.; Nikolaev, V.O.
Real-time monitoring of phosphodiesterase inhibition in intact cells
Cell. Signal.
20
1423-1431
2008
Homo sapiens (P27815)
Lynex, C.N.; Li, Z.; Chen, M.L.; Toh, K.Y.; Low, R.W.; Goh, D.L.; Tay, S.K.
Identification and molecular characterization of a novel PDE4D11 cAMP-specific phosphodiesterase isoform
Cell. Signal.
20
2247-2255
2008
Mus musculus (B1PSD9), Mus musculus
Goldhoff, P.; Warrington, N.M.; Limbrick, D.D.; Hope, A.; Woerner, B.M.; Jackson, E.; Perry, A.; Piwnica-Worms, D.; Rubin, J.B.
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
Clin. Cancer Res.
14
7717-7725
2008
Homo sapiens
Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries
Eur. J. Pharmacol.
582
102-109
2008
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens (Q13946), Homo sapiens
van Donkelaar, E.L.; Rutten, K.; Blokland, A.; Akkerman, S.; Steinbusch, H.W.; Prickaerts, J.
Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion
Eur. J. Pharmacol.
600
98-104
2008
Rattus norvegicus
Kimura, Y.; Okazaki, N.; Takegawa, K.
Enzymatic characteristics of two novel Myxococcus xanthus enzymes, PdeA and PdeB, displaying 3',5'- and 2'3'-cAMP phosphodiesterase, and phosphatase activities
FEBS Lett.
583
443-448
2009
Myxococcus xanthus
Tawar, U.; Kotlo, K.; Jain, S.; Shukla, S.; Setty, S.; Danziger, R.S.
Renal phosphodiesterase 4B is activated in the Dahl salt-sensitive rat
Hypertension
51
762-766
2008
Rattus norvegicus
Chan, A.L.; Huang, H.L.; Chien, H.C.; Chen, C.M.; Lin, C.N.; Ko, W.C.
Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3H]-rolipram binding in guinea pig tissues
Invest. New Drugs
26
417-424
2008
Cavia porcellus
Maschi, O.; Cero, E.D.; Galli, G.V.; Caruso, D.; Bosisio, E.; DellAgli, M.
Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L
J. Agric. Food Chem.
56
5015-5020
2008
Homo sapiens
Kim, H.S.; Kim, S.M.; Lee, H.J.; Park, S.J.; Lee, K.H.
Expression of the cpdA gene, encoding a 3',5'-cyclic AMP (cAMP) phosphodiesterase, is positively regulated by the cAMP-cAMP receptor protein complex
J. Bacteriol.
191
922-930
2009
Vibrio vulnificus (Q846Z1)
Ivey, F.D.; Demirbas, D.; Allain, C.; Hoffmann, C.S.
Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases
J. Biomol. Screen.
13
62-71
2008
Mus musculus
Nishi, A.; Kuroiwa, M.; Miller, D.B.; O'Callaghan, J.P.; Bateup, H.S.; Shuto, T.; Sotogaku, N.; Fukuda, T.; Heintz, N.; Greengard, P.; Snyder, G.L.
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
J. Neurosci.
28
10460-10471
2008
Mus musculus
Bopp, C.; Hofer, S.; Busch, C.; Spoehr, F.; Weigand, M.A.; Martin, E.; Klein, A.
Time-limited hyporesponsiveness to inhaled nitric oxide and pulmonary phosphodiesterase activity in endotoxemic rats
J. Surg. Res.
150
66-73
2008
Rattus norvegicus
De Arcangelis, V.; Soto, D.; Xiang, Y.
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor
Mol. Pharmacol.
74
1453-1462
2008
Mus musculus
Galindo-Tovar, A.; Vargas, M.L.; Kaumann, A.J.
Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium
Naunyn Schmiedebergs Arch. Pharmacol.
379
379-384
2009
Rattus norvegicus
Dlaboga, D.; Hajjhussein, H.; ODonnell, J.M.
Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum
Neuropharmacology
54
745-754
2008
Rattus norvegicus
Shakiryanova, D.; Levitan, E.S.
Prolonged presynaptic posttetanic cyclic GMP signaling in Drosophila motoneurons
Proc. Natl. Acad. Sci. USA
105
13610-13613
2008
Drosophila melanogaster
Goncalves, R.L.; Lugnier, C.; Keravis, T.; Lopes, M.J.; Fantini, F.A.; Schmitt, M.; Cortes, S.F.; Lemos, V.S.
The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue
Eur. J. Pharmacol.
620
78-83
2009
Bos taurus
Togo, S.; Liu, X.; Wang, X.; Sugiura, H.; Kamio, K.; Kawasaki, S.; Kobayashi, T.; Ertl, R.F.; Ahn, Y.; Holz, O.; Magnussen, H.; Fredriksson, K.; Skold, C.M.; Rennard, S.I.
PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-beta1-stimulated fibroblasts
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L959-L969
2009
Homo sapiens
Guo, J.; Watson, A.; Kempson, J.; Carlsen, M.; Barbosa, J.; Stebbins, K.; Lee, D.; Dodd, J.; Nadler, S.G.; McKinnon, M.; Barrish, J.; Pitts, W.J.
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation
Bioorg. Med. Chem. Lett.
19
1935-1938
2009
Homo sapiens
Kagayama, K.; Morimoto, T.; Nagata, S.; Katoh, F.; Zhang, X.; Inoue, N.; Hashino, A.; Kageyama, K.; Shikaura, J.; Niwa, T.
Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
Bioorg. Med. Chem.
17
6959-6970
2009
Homo sapiens
Schafer, P.H.; Parton, A.; Gandhi, A.K.; Capone, L.; Adams, M.; Wu, L.; Bartlett, J.B.; Loveland, M.A.; Gilhar, A.; Cheung, Y.F.; Baillie, G.S.; Houslay, M.D.; Man, H.W.; Muller, G.W.; Stirling, D.I.
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis
Br. J. Pharmacol.
159
842-855
2010
Homo sapiens
Hatzimouratidis, K.; Hatzichristou, D.G.
Phosphodiesterase type 5 inhibitors: unmet needs
Curr. Pharm. Des.
15
3476-3485
2009
Homo sapiens
Miwa, T.; Mori, A.; Nakahara, T.; Ishii, K.
Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats
Eur. J. Pharmacol.
602
112-116
2009
Rattus norvegicus
Lee, F.P.; Shih, C.M.; Shen, H.Y.; Chen, C.M.; Chen, C.M.; Ko, W.C.
Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia
Eur. J. Pharmacol.
635
198-203
2010
Mus musculus
Wang, Y.J.; Jiang, Y.L.; Tang, H.F.; Zhao, C.Z.; Chen, J.Q.
Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model
Int. Immunopharmacol.
10
252-258
2010
Rattus norvegicus
Fuchs, E.L.; Brutinel, E.D.; Klem, E.R.; Fehr, A.R.; Yahr, T.L.; Wolfgang, M.C.
In vitro and in vivo characterization of the Pseudomonas aeruginosa cAMP phosphodiesterase CpdA required for cAMP homeostasis and virulence factor regulation
J. Bacteriol.
192
2779-2790
2010
Pseudomonas aeruginosa (D4P095), Pseudomonas aeruginosa
Dodge-Kafka, K.L.; Bauman, A.; Mayer, N.; Henson, E.; Heredia, L.; Ahn, J.; McAvoy, T.; Nairn, A.C.; Kapiloff, M.S.
cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3
J. Biol. Chem.
285
11078-11086
2010
Rattus norvegicus
Cashman, J.R.; Voelker, T.; Zhang, H.T.; ODonnell, J.M.
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake
J. Med. Chem.
52
1530-1539
2009
Mus musculus
Rock, E.M.; Benzaquen, J.; Limebeer, C.L.; Parker, L.A.
Potential of the rat model of conditioned gaping to detect nausea produced by rolipram, a phosphodiesterase-4 (PDE4) inhibitor
Pharmacol. Biochem. Behav.
91
537-541
2009
Rattus norvegicus
Zhang, L.; Murray, F.; Zahno, A.; Kanter, J.R.; Chou, D.; Suda, R.; Fenlon, M.; Rassenti, L.; Cottam, H.; Kipps, T.J.; Insel, P.A.
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia
Proc. Natl. Acad. Sci. USA
105
19532-19537
2008
Homo sapiens
Korkmaz, S.; Maupoil, V.; Sobry, C.; Brunet, C.; Chevalier, S.; Freslon, J.L.
An increased regional blood flow precedes mesenteric inflammation in rats treated by a phosphodiesterase 4 inhibitor
Toxicol. Sci.
107
298-305
2009
Rattus norvegicus
MacKenzie, K.F.; Wallace, D.A.; Hill, E.V.; Anthony, D.F.; Henderson, D.J.; Houslay, D.M.; Arthur, J.S.; Baillie, G.S.; Houslay, M.D.
Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation
Biochem. J.
435
755-769
2011
Rattus norvegicus (P54748)
Matveeva, N.; Morozov, M.; Nezvetskiǐ, A.; Orlova, T.; Teplov, V.; Beǐlina, S.
[Involvement of extracellular cAMP-specific phosphodiesterase in control of motile activity of Physarum polycephalum plasmodium]
Biofizika
55
1076-1082
2010
Physarum polycephalum
Nunes, A.R.; Batuca, J.R.; Monteiro, E.C.
Acute hypoxia modifies cAMP levels induced by inhibitors of phosphodiesterase-4 in rat carotid bodies, carotid arteries and superior cervical ganglia
Br. J. Pharmacol.
159
353-361
2010
Rattus norvegicus
Cheng, D.; Ren, J.; Gillespie, D.G.; Mi, Z.; Jackson, E.K.
Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats
Hypertension
56
1096-1101
2010
Rattus norvegicus
Rampersad, S.; Ovens, J.; Huston, E.; Umana, M.; Wilson, L.; Netherton, S.; Lynch, M.; Baillie, G.; Houslay, M.; Maurice, D.
Cyclic AMP phosphodiesterase 4D (PDE4D) tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability
J. Biol. Chem.
285
33614-33622
2010
Homo sapiens
Chen, X.; Zhao, X.; Xiong, Y.; Liu, J.; Zhan, C.G.
Fundamental reaction pathway and free energy profile for hydrolysis of intracellular second messenger adenosine 3',5'-cyclic monophosphate (cAMP) catalyzed by phosphodiesterase-4
J. Phys. Chem. B
115
12208-12219
2011
Homo sapiens
Tsai, L.C.; Shimizu-Albergine, M.; Beavo, J.A.
The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland
Mol. Pharmacol.
79
639-648
2011
Mus musculus
Lakics, V.; Karran, E.H.; Boess, F.G.
Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
Neuropharmacology
59
367-374
2010
Homo sapiens (O60658), Homo sapiens (O95263), Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens (Q13946), Homo sapiens (Q9NP56)
Adderley, S.P.; Sprague, R.S.; Stephenson, A.H.; Hanson, M.S.
Regulation of cAMP by phosphodiesterases in erythrocytes
Pharmacol. Rep.
62
475-482
2010
Homo sapiens
Ramanujam, R.; Naqvi, N.
PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzae
PLoS Pathog.
6
e1000897
2010
Pyricularia oryzae (D0ERY7), Pyricularia oryzae (D0ERY8)
Weninger, S.; Van Craenenbroeck, K.; Cameron, R.T.; Vandeput, F.; Movsesian, M.A.; Baillie, G.S.; Lefebvre, R.A.
Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling
Cell. Signal.
26
2573-2582
2014
Homo sapiens
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
Schwebs, D.J.; Nguyen, H.N.; Miller, J.A.; Hadwiger, J.A.
Loss of cAMP-specific phosphodiesterase rescues spore development in G protein mutant in Dictyostelium
Cell. Signal.
26
409-418
2014
Dictyostelium discoideum (Q23917)
Lee, J.; Komatsu, K.; Lee, B.C.; Lim, J.H.; Jono, H.; Xu, H.; Kai, H.; Zhang, Z.J.; Yan, C.; Li, J.D.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway
J. Biol. Chem.
287
22799-22811
2012
Homo sapiens
Mika, D.; Richter, W.; Westenbroek, R.E.; Catterall, W.A.; Conti, M.
PDE4B mediates local feedback regulation of beta1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
J. Cell Sci.
127
1033-1042
2014
Mus musculus
Garcia, A.M.; Brea, J.; Morales-Garcia, J.A.; Perez, D.I.; Gonzalez, A.; Alonso-Gil, S.; Gracia-Rubio, I.; Ros-Simo, C.; Conde, S.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Valverde, O.; Martinez, A.; Gil, C.
Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors
J. Med. Chem.
57
8590-8607
2014
Homo sapiens (Q07343), Homo sapiens (Q08499), Homo sapiens (Q13946), Homo sapiens
Bergeron, A.; Aragon, J.P.; Guillemette, C.; Hebert, A.; Sullivan, R.; Blondin, P.; Richard, F.J.
Characterization of cAMP-phosphodiesterase activity in bovine seminal plasma
Andrology
4
1123-1130
2016
Bos taurus
Wahlang, B.; McClain, C.; Barve, S.; Gobejishvili, L.
Role of cAMP and phosphodiesterase signaling in liver health and disease
Cell. Signal.
49
105-115
2018
Homo sapiens
Cai, Y.; Nagel, D.J.; Zhou, Q.; Cygnar, K.D.; Zhao, H.; Li, F.; Pi, X.; Knight, P.A.; Yan, C.
Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia
Circ. Res.
116
1120-1132
2015
Homo sapiens, Mus musculus, Rattus norvegicus
Cao, B.; Wang, K.; Liao, J.M.; Zhou, X.; Liao, P.; Zeng, S.X.; He, M.; Chen, L.; He, Y.; Li, W.; Lu, H.
Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation
eLife
5
e15978
2016
Homo sapiens (Q08499), Homo sapiens
Guo, L.; Luo, L.; Ju, R.; Chen, C.; Zhu, L.; Li, J.; Yu, X.; Ye, C.; Zhang, D.
Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases
Eur. J. Pharmacol.
746
14-21
2015
Mus musculus, Rattus norvegicus
Byrne, A.M.; Elliott, C.; Hoffmann, R.; Baillie, G.S.
The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus
FEBS Lett.
589
750-755
2015
Homo sapiens (Q08499)
Matange, N.
Revisiting bacterial cyclic nucleotide phosphodiesterases cyclic AMP hydrolysis and beyond
FEMS Microbiol. Lett.
362
fnv183
2015
Serratia marcescens, Escherichia coli (P0AEW4)
Ju-Rong, Y.; Ke-Hong, C.; Kun, H.; Bi-Qiong, F.; Li-Rong, L.; Jian-Guo, Z.; Kai-Long, L.; Ya-Ni, H.
Transcription factor Trps1 promotes tubular cell proliferation after ischemia-reperfusion injury through cAMP-specific 3',5'-cyclic phosphodiesterase 4D and AKT
J. Am. Soc. Nephrol.
28
532-544
2017
Rattus norvegicus (P14270)
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