3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase
This is an abbreviated version!
For detailed information about 3',5'-cyclic-AMP phosphodiesterase, go to the full flat file.
Word Map on EC 3.1.4.53
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3.1.4.53
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rolipram
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pulmonary
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phosphodiesterases
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roflumilast
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asthma
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airway
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cyclase
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pka
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psoriasis
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agonist
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apremilast
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inhale
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tnf
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camp-dependent
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atopic
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dermatitis
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corticosteroid
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cgmp
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forskolin
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bronchodilator
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adenylyl
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eosinophil
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nausea
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bronchoalveolar
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emesis
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long-acting
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theophylline
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camp-pde
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salbutamol
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ointment
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ibmx
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pruritus
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cilostamide
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moderate-to-severe
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milrinone
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bronchoconstriction
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camp-mediated
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zaprinast
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medicine
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salmeterol
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pcreb
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beta2ars
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beta2-adrenoceptors
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labas
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camp-elevating
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beta2-agonists
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pde10a
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cgmp-specific
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molecular biology
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akaps
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tofacitinib
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ustekinumab
- 3.1.4.53
- rolipram
- pulmonary
- phosphodiesterases
- roflumilast
- asthma
- airway
- cyclase
- pka
- psoriasis
- agonist
- apremilast
-
inhale
- tnf
-
camp-dependent
-
atopic
- dermatitis
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corticosteroid
- cgmp
- forskolin
-
bronchodilator
-
adenylyl
-
eosinophil
-
nausea
-
bronchoalveolar
- emesis
-
long-acting
- theophylline
- camp-pde
- salbutamol
-
ointment
- ibmx
- pruritus
- cilostamide
-
moderate-to-severe
- milrinone
-
bronchoconstriction
-
camp-mediated
- zaprinast
- medicine
- salmeterol
-
pcreb
-
beta2ars
-
beta2-adrenoceptors
-
labas
-
camp-elevating
-
beta2-agonists
- pde10a
-
cgmp-specific
- molecular biology
-
akaps
-
tofacitinib
-
ustekinumab
Reaction
Synonyms
3',5'-cAMP phosphodiesterase, 3',5'-cyclic AMP phosphodiesterase, adenosine 3',5'-cyclic monophosphate PDE, adenosine 3',5'-cyclicmonophosphate-specific PDE, cAMP phosphodiesterase, cAMP phosphodiesterase-4, cAMP-PDE, cAMP-phosphodiesterase, cAMP-phosphodiesterase 1C, cAMP-phosphodiesterase 4D7, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific cyclic nucleotide phosphodiesterase, cAMP-specific PDE, cAMP-specific PDE4A5, cAMP-specific PDE4D2, cAMP-specific phosphodiesterase, cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase 4D11, cAMP-specific phosphodiesterase-4D5, cAMPspecific PDE, class I phosphodiesterase PDEB1, class I phosphodiesterase PDEB2, CpdA, CPDS, cyclic AMP phosphodiesterase type 4, cyclic AMP phosphodiesterase-4, cyclic AMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic nucleotide phosphodiesterase 4, cyclic nucleotide phosphodiesterase 4D, cyclic nucleotide phosphodiesterase-8A, DdPDE4, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, hPDE4A, hPDE4B, HSPDE4A4B, LmjPDEB1, LmjPDEB2, PDE, PDE IVB, PDE-46, PDE-4D3, PDE10A, PDE1C, PDE2, PDE3, PDE4, PDE4A, PDE4A cAMP-specific phosphodiesterase splice variant RD1, PDE4A1, PDE4A10, PDE4A4, PDE4A5, PDE4A8, PDE4B, PDE4B1, PDE4B2, PDE4B3, PDE4B4, PDE4B5, PDE4C, PDE4C2, PDE4D, PDE4D1, PDE4D11, PDE4D3, PDE4D5, PDE4D7, PDE5, PDE7, PDE7A, PDE7A1, PDE7A2, PDE7B, PDE8, PDE8A, PDE8A1, PDE8B, PdeA, PdeB, PDEB1, PdeH, PdeL, phosphodiesterase 4, phosphodiesterase 4 isoform A8, phosphodiesterase 4B, phosphodiesterase 4D, phosphodiesterase 5, phosphodiesterase 7, phosphodiesterase 7B, phosphodiesterase type 4, phosphodiesterase type 5, phosphodiesterase-4, phosphodiesterase-4A5, phosphodiesterase-4B, RegA, RNPDE4A1A, TbPDE1, TbPDE2B, TbrPDEB1, TbrPDEB2, TcPDE1, TcPDE4, TcrPDEA1, TcrPDEB1
ECTree
3.1.4.53 3',5'-cyclic-AMP phosphodiesteraseAdvanced search results
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Source Tissue on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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phosphodiesterase 4 is detected in smooth muscle cells of the wall, and in the cytoplasm of luminal endothelial cells of cavernous arteries
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presence of isoform PDE4 in nonvascular smooth musculature of the corpus carnosum
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
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sinusoidal endothelial and subendothelialn layer of clitoris, presence of isoform PDE4
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lowering cyclic adenosine-3',5'-monophosphate levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
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PDE4B. Ablation of PDE4B partially protects mice from LPS-induced shock
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gingiva-derived malignant melanoma cell, expression of variants PDE4B and PDE4D
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monocytic cells may express different PDE4 isozymes, depending on their state of activation or differentiation. These isozymes could thus regulate intracellular cAMP levels at various stages of monocyte activation and could thereby be important in limiting the inflammatory response
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strong expression of isoform PDE4 throughout the nervous system
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abundantly present in the fibromusclular stroma as well as in glandular structures of the transition zone
additional information
PDE4A expression in GH-secreting adenomas is highly variable and independent from the presence of the gsp oncogene
PDE4B expression in GH-secreting adenomas is highly variable and independent from the presence of the gsp oncogene
the level of PDE4C transcripts in gsp+ tumors is significantly higher than that found in gsp- adenomas
the level of PDE4D transcripts in gsp+ tumors is significantly higher than that found in gsp- adenomas
tumor tissues from patients with isolated micronodular adrenocortical disease and no mutations in the coding PDE8B sequence or any other related genes (PRKAR1A, PDE11A) show downregulated PDE8B expression compared to normal adrenal cortex. PDE8B is a PDE gene linked to isolated micronodular adrenocortical disease. It is a candidate causative gene for other adrenocortical lesions linked to the cAMP signaling pathway and possibly for tumors in other tissues
parietal, frontal, temporal cortex, hippocampus, striatum, thalamus, hypothalamus, substantia nigra, nucleus accumbens, cerebellum
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
in the brain, PDE4D11 expression levels increase in the cerebellum, but decrease in the hippocampus with progressive age
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isoforms PDE4A, PDE4D, PDE7A, PDE8A, PDE8B show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE7A, PDE7B does not change with age. Age-related increases in PDE11A4, PDE8A3, PDE8A4/5, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
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isoforms PDE4A, PDE4D, PDE7A, PDE8A, PDE8B show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE7A, PDE7B does not change with age. Age-related increases in PDE11A4, PDE8A3, PDE8A4/5, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
PDE4D11 expression levels increase in the cerebellum with progressive age
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PDE4 is observed in the nonvascular smooth musculature of the corpus cavernosum clitoris, sinusoidal endothelial and subendothelial layers, and nerve fibers innervating the tissue
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presence of isoform PDE4 in nonvascular smooth musculature of the corpus carnosum, in sinusoidal endothelial and subendothelial layers, and nerve fiber innervating the tissue
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age-related increases in isoform PDE8A3 protein expression are confirmed in hippocampus of old versus young rodents
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age-related increases in isoform PDE8A3 protein expression are confirmed in hippocampus of old versus young rodents
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
PDE4D11 expression levels decrease in the hippocampus with progressive age
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age-related increases in isoforms PDE8A3, PDE8A4/5 and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents
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age-related increases in isoforms PDE8A3, PDE8A4/5 protein expression are confirmed in hippocampus of old versus young rodents. Relative to young rats, the hippocampi of old rats demonstrate strikingly decreased phosphorylation of GluR1, CaMKIIalpha, and CaMKIIbeta, decreased expression of the transmembrane AMPA regulatory proteins gamma2 (a.k.a. stargazin) and gamma8, and increased trimethylation of H3K27. Expression of isoforms of PDE8A4/5, PDE8A3 correlate with these functional endpoints in young but not old rats
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
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the phosphodiesterase 4B4 isoform present in kidney tissue from spontaneously hypertensive rats, hypertensive Dahl salt-sensitive rats, and Dahl salt-resistant rats, phosphodiesterase 4B expression is detected in the renal vasculature, proximal tubules, and distal tubules
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
most highly expressed in pancreas followed by brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus, and liver
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immature cell. Almost all PDE4D variants are expressed throughout the early postpartum period with a specific increase in PDE4 activity in both soluble and particulate fraction of 20 day old Sertoli cells
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isolated from 10-, 20-, and 30-days-old rats. Specific increase in PDE4 activity in both the soluble and particulate subcellular fractions of 20-days-old Sertoli cells. Almost all the PDE4D isoforms, known as the main cAMP-regulated rolipramsensitive PDE in Sertoli cells, are expressed throughout the early postpartum period, whereas only the short PDE4D isoforms (PDE4D1 and PDE4D2) are transcriptionally regulated by FSH. The subcellular distribution and expression of PDE4D proteins are unaffected by the developmental status of the Sertoli cells. Only the expression of short PDE4D1 appears to be upregulated by FSH and only in 20-days-old Sertoli cells, which suggests phenotype-dependent differential regulation of Pde4d1 mRNA translation
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
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PDE4 is present in young and adult gland. During development PDE4 is the major PDE
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order. In testis PDE8 is expressed in the seminiferous epithelium in a stage-specific manner
numerous PDE4D gene-derived variants including PDE4D3, PDE4D5, PDE4D7, PDE4D8, and PDE4D9
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
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mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
PDE IVB is not detected in Placenta, liver, kidney, or pancreas
additional information
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PDE IVB is not detected in Placenta, liver, kidney, or pancreas
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
determination of tissue distribution and level of the different PDE isozymes via quantitative real-time PCR expresssion analysis, overview
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
additional information
mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes
