3.1.21.1: deoxyribonuclease I
This is an abbreviated version!
For detailed information about deoxyribonuclease I, go to the full flat file.
Reaction
endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
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Synonyms
alkaline deoxyribonuclease, alkaline DNase, alkaline nuclease, bovine pancreatic deoxyribonuclease I, bovine pancreatic DNase, bp-DNase I, bpDNase, carp liver DNase, ColE7, ColE9, colicin, colicin E2, Colicin E9, CRM197, deoxyribonuclease, deoxyribonuclease (pancreatic), deoxyribonuclease 1, deoxyribonuclease 1-like 3, deoxyribonuclease A, deoxyribonuclease I, deoxyribonuclease I-like enzyme, deoxyribonuclease-1, deoxyribonucleic phosphatase, desoxyribonuclease, diphtheria toxin, DNA endonuclease, DNA nuclease, DNA polymerase, DNAase, DNase, DNase 1, DNase A, DNase B, DNase C, DNase D, DNase I, DNase I-like enzyme, Dnase Y, DNase-I, Dnase1, DNase1-like 3, DNase1/3, DNASE1L3, DNaseI, domase, Dornase alfa, dornase alpha, dornava, dornavac, DTx, E9 Dnase, EC 3.1.4.5, endodeoxyribinuclease I, endodeoxyribonuclease I, EndoDNase, Escherichia coli endonuclease I, extracellular nuclease, hDNase I, lactoferrin, More, neutral DNase, neutral nuclease, nuclease Bh1, nuclease Stn beta, nuclease, deoxyribo-, nuclease, Escherichia coli endo-, I, NucT, OmpA, outer membrane protein A, pancreatic deoxyribonuclease, pancreatic DNase, pancreatic DNase I, pancreatic dornase, Potyviral Ia Proeinase, pulmozyme, rhDNaseI, PVBV proteinase, SdaD2, Slx1, Spd, Spd3, SsnA, streptodornase, tear lipocalin, thymonuclease, type I DNAse I, Vvn
ECTree
Source Tissue
Source Tissue on EC 3.1.21.1 - deoxyribonuclease I
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blood plasma of 40 non-pregnant women, 40 healthy pregnant women (over 37 weeks) and 40 pregnant women with a diagnosis of intrauterine growth restriction
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leukemic cells
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multi-drug resistant cell line
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mid-previtellogenesis epithelium and late previtellogenesis epithelium
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low activity
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low activity
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pars glandularis
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low activity
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somatostatin-sensitive enzyme form
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somatostatin-sensitive enzyme form
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low activity
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somatostatin-sensitive enzyme form
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microplasmodium
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low activity
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poor activity
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of embryo
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enzyme secretion
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enzyme secretion
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embryonic brain
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highest enzyme expression and activity
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low activity
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low activity
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poor activity
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high expression level
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high DNase1 content
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high DNase1 content
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somatostatin-resistant enzyme form
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low activity
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low activity
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poor activity
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somatostatin-resistant enzyme form
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low activity
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highest activity in vitellogenic, activity increases during oogenesis, low activity in young oocytes
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MII oocyte
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134199, 134208, 134210, 134213, 134219, 134221, 134222, 134223, 134227, 134233, 134234, 134236, 134237, 134238, 650325, 653799, 666854, 695970, 696064, 696291, 697759, 699637, 700518, 701077, 701089, 716661 brenda
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high activity
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highest enzyme activity and expression
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high activity
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poor activity
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very high expression level
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from homozygote subjects
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high activity
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high activity
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highest activity
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somatostatin-resistant enzyme form
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low activity
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DNase1/3
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systemic lupus erythematosus patients have lower serum DNase 1 activity compared with healthy controls
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contains two nucleases, DNase1 and DNase1/3. DNase1/3 is not N-glycosylated, whereas DNase1 is di-N-glycosylated
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lupus-prone NZB/NZW mice have significantly lower serum concentrations of DNase 1 than normal mice, and this reduction is not related to the presence of actin
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contains two nucleases, DNase1 and DNase1/3. DNase1/3 is not N-glycosylated, whereas DNase1 is di-N-glycosylated
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somatostatin-sensitive enzyme form
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low activity
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low activity
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low activity
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poor activity
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high expression level
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low activity
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somatostatin-sensitive enzyme form
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low activity
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high DNase1/3 content
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high DNase1/3 content
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somatostatin-sensitive enzyme form
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10 phenotypes
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highest activity
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lupus-prone NZB/NZW mice have significantly lower urine concentrations of DNase 1 than normal mice, and this reduction is not related to the presence of actin
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additional information
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pancreas-parotid
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additional information
no activity in cerebrum, heart, lung, liver, kidney, spleen, skin, muscle, oesophagus, stomach, duodenum, and large intestine
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additional information
no activity in spleen, parotid gland, lung, heart, cerebellum, and cerebrum
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additional information
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no activity in spleen, parotid gland, lung, heart, cerebellum, and cerebrum
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additional information
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no activity in cerebrum, heart, lung, liver, kidney, spleen, skin, muscle, oesophagus, stomach, duodenum, and large intestine
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additional information
no activity in cerebrum, heart, lung, liver, kidney, spleen, skin, muscle, oesophagus, stomach, duodenum, and large intestine
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additional information
no activity in brain
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additional information
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no activity in brain
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additional information
marked correlation between tissue distribution of enzyme and its sensitivity/resistance to proteolysis
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additional information
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secretion of enzyme is controlled by the chief cells in the stomach
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additional information
tissue distribution of enzymes of the DNase I family, complete overview
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additional information
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tissue distribution of enzymes of the DNase I family, complete overview
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additional information
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a fraction of abzymes from autoimmune patients hydrolyzing both DNA and RNA can contain a subfraction of antibodies against DNase I
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additional information
no activity in cerebrum, heart, lung, liver, kidney, spleen, skin, muscle, oesophagus, stomach, duodenum, and large intestine
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additional information
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EG-1 cell
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additional information
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pyriform cell
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additional information
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secretion of enzyme is controlled by the chief cells in the stomach
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additional information
no activity in spleen, heart, lung, stomach, large intestine, cerebrum, cerebellum, submaxillary gland, and thymus
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additional information
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no activity in spleen, heart, lung, stomach, large intestine, cerebrum, cerebellum, submaxillary gland, and thymus
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