3.1.21.1: deoxyribonuclease I

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For detailed information about deoxyribonuclease I, go to the full flat file.

Reaction

endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products =

Synonyms

alkaline deoxyribonuclease, alkaline DNase, alkaline nuclease, bovine pancreatic deoxyribonuclease I, bovine pancreatic DNase, bp-DNase I, bpDNase, carp liver DNase, ColE7, ColE9, colicin, colicin E2, Colicin E9, CRM197, deoxyribonuclease, deoxyribonuclease (pancreatic), deoxyribonuclease 1, deoxyribonuclease 1-like 3, deoxyribonuclease A, deoxyribonuclease I, deoxyribonuclease I-like enzyme, deoxyribonuclease-1, deoxyribonucleic phosphatase, desoxyribonuclease, diphtheria toxin, DNA endonuclease, DNA nuclease, DNA polymerase, DNAase, DNase, DNase 1, DNase A, DNase B, DNase C, DNase D, DNase I, DNase I-like enzyme, Dnase Y, DNase-I, Dnase1, DNase1-like 3, DNase1/3, DNASE1L3, DNaseI, domase, Dornase alfa, dornase alpha, dornava, dornavac, DTx, E9 Dnase, EC 3.1.4.5, endodeoxyribinuclease I, endodeoxyribonuclease I, EndoDNase, Escherichia coli endonuclease I, extracellular nuclease, hDNase I, lactoferrin, More, neutral DNase, neutral nuclease, nuclease Bh1, nuclease Stn beta, nuclease, deoxyribo-, nuclease, Escherichia coli endo-, I, NucT, OmpA, outer membrane protein A, pancreatic deoxyribonuclease, pancreatic DNase, pancreatic DNase I, pancreatic dornase, Potyviral Ia Proeinase, pulmozyme, rhDNaseI, PVBV proteinase, SdaD2, Slx1, Spd, Spd3, SsnA, streptodornase, tear lipocalin, thymonuclease, type I DNAse I, Vvn

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

                3.1.21.1 deoxyribonuclease I

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Results	in table
14	Activating Compound
1561	AA Sequence
37	Application
1	CAS Registry Number
47	Cloned(Commentary)
6	Crystallization (Commentary)
30251	Disease/ Diagnostics
2	Expression
2	General Information
12	General Stability
8	IC50 Value
205	Inhibitors
7	Ki Value [mM]
11	KM Value [mM]
47	Localization
207	Metals/Ions
58	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
5	Organic Solvent Stability
181	Organism
61	PDB ID
61	pH Optimum
9	pH Range
3	pH Stability
7	pI Value
37	Posttranslational Modification
132	Protein Variants
61	Purification (Commentary)
15	Reaction
34	Reaction Type
166	Reference
1	Renatured (Commentary)
214	Source Tissue
52	Specific Activity [micromol/min/mg]
9	Storage Stability
223	Substrates and Products (Substrate)
32	Subunits
238	Synonyms
19	Temperature Optimum [°C]
4	Temperature Range [°C]
17	Temperature Stability [°C]
10	Turnover Number [1/s]

Expression

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Expression on EC 3.1.21.1 - deoxyribonuclease I

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

high glucose induces both DNase I and caspase-3

Rattus norvegicus

-

730378

significant increase of DNase I activity in cases of intrauterine growth restriction. Increase in DNase I activity over a certain threshold indicates presence of pathological processes in the organism

Homo sapiens

P24855

750009