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3.1.21.1: deoxyribonuclease I

This is an abbreviated version!
For detailed information about deoxyribonuclease I, go to the full flat file.

Word Map on EC 3.1.21.1

Reaction

endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products =

Synonyms

alkaline deoxyribonuclease, alkaline DNase, alkaline nuclease, bovine pancreatic deoxyribonuclease I, bovine pancreatic DNase, bp-DNase I, bpDNase, carp liver DNase, ColE7, ColE9, colicin, colicin E2, Colicin E9, CRM197, deoxyribonuclease, deoxyribonuclease (pancreatic), deoxyribonuclease 1, deoxyribonuclease 1-like 3, deoxyribonuclease A, deoxyribonuclease I, deoxyribonuclease I-like enzyme, deoxyribonuclease-1, deoxyribonucleic phosphatase, desoxyribonuclease, diphtheria toxin, DNA endonuclease, DNA nuclease, DNA polymerase, DNAase, DNase, DNase 1, DNase A, DNase B, DNase C, DNase D, DNase I, DNase I-like enzyme, Dnase Y, DNase-I, Dnase1, DNase1-like 3, DNase1/3, DNASE1L3, DNaseI, domase, Dornase alfa, dornase alpha, dornava, dornavac, DTx, E9 Dnase, EC 3.1.4.5, endodeoxyribinuclease I, endodeoxyribonuclease I, EndoDNase, Escherichia coli endonuclease I, extracellular nuclease, hDNase I, lactoferrin, More, neutral DNase, neutral nuclease, nuclease Bh1, nuclease Stn beta, nuclease, deoxyribo-, nuclease, Escherichia coli endo-, I, NucT, OmpA, outer membrane protein A, pancreatic deoxyribonuclease, pancreatic DNase, pancreatic DNase I, pancreatic dornase, Potyviral Ia Proeinase, pulmozyme, rhDNaseI, PVBV proteinase, SdaD2, Slx1, Spd, Spd3, SsnA, streptodornase, tear lipocalin, thymonuclease, type I DNAse I, Vvn

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
                3.1.21.1 deoxyribonuclease I

General Information

General Information on EC 3.1.21.1 - deoxyribonuclease I

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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in uninduced K-562 cells, several sites within HMIP-2 show sensitivity to DNase I above background levels. When cells are induced to differentiate, the region shows a general increase in DNase I sensitivity: 3 sites refer to here as HBS1L-MYB HS1, HS2, and HS3, in particular, show a marked increase in sensitivity compared with background levels. DNase I sensitivity also increases for betaHS2 and betaHS3 controls. HBS1L-MYB HS1, HS2, and HS3 also show stronger sensitivity to DNase I than the betaHS3 control, thereby reaching a threshold level for hypersensitivity. No difference in DNase I sensitivity for NEFM in uninduced and induced K-562 cells. BetaHS2 is not sensitive to DNase I in Jurkat cells. Jurkat cells show similar background levels and generally, a similar DNase I sensitivity profile to induced K562 cells, but with much less sensitivity at HBS1L-MYB HS1, HS2, and HS3. The strongest sensitivity to DNase I in Jurkat cells coincides with the putative promoter region of the alternative HBS1L exon (exon 1a), which shows a low degree of sensitivity in K-562 cells (both uninduced and induced)
additional information