Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.21.1 extracted from

  • Ueki, M.; Takeshita, H.; Fujihara, J.; Ueta, G.; Nakajima, T.; Kominato, Y.; Kishi, K.; Iida, R.; Yasuda, T.
    Susceptibility of mammalian deoxyribonucleases I (DNases I) to proteolysis by proteases and its relationships to tissue distribution: Biochemical and molecular analysis of equine DNase I (2007), Comp. Biochem. Physiol. B, 148B, 93-102.
No PubMed abstract available
Search for more literature for 3.1.21.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cell Equus caballus

Inhibitors

Inhibitors Comment Organism Structure
EDTA 10 mM, complete loss of activity Equus caballus
EGTA 1 mM, complete loss of activity Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus Q4AEE3
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein protein contains a N-linked carbohydrate moiety. Potential glycosylation sites at N18 and N106 Equus caballus

Purification (Commentary)

Purification (Comment) Organism
from parotid gland Equus caballus

Source Tissue

Source Tissue Comment Organism Textmining
kidney poor activity Equus caballus
-
liver poor activity Equus caballus
-
additional information marked correlation between tissue distribution of enzyme and its sensitivity/resistance to proteolysis Equus caballus
-
pancreas poor activity Equus caballus
-
parotid gland high activity Equus caballus
-
small intestine poor activity Equus caballus
-
submaxillary gland poor activity Equus caballus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3600
-
 pH 6.5 Equus caballus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O
-
 Equus caballus 5'-phosphodinucleotide + 5'-phosphooligonucleotide
-
 ?