1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 11-cis-RDH, 11-cis-retinol dehydrogenase, 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), atRDH, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, RDH10, retinol dehydrogenase 10, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.87 - homoisocitrate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+
2-oxoadipate + CO2 + NADH + H+
show the reaction diagram
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+
2-oxoadipate + NADH + H+ + CO2
show the reaction diagram
(2R,3S)-3-(2-hydroxyethyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(3-aminopropyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(3-hydroxypropyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(4-hydroxybutyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(4-pentenyl)malic acid + NAD+
?
show the reaction diagram
(2R,3S)-3-allylmalic acid + NAD+
?
show the reaction diagram
(2R,3S)-3-propylmalic acid + NAD+
?
show the reaction diagram
1-hydroxy-1,2,3-propanetricarboxylate + NAD+
?
show the reaction diagram
-
more effective substrate than 1-hydroxy-1,2,4-butanetricarboxylate
-
-
?
1-hydroxy-1,2,4-butanetricarboxylate + NAD+
2-oxoadipate + CO2 + NADH
show the reaction diagram
11-cis-retinol + NAD+
11-cis-retinal + NADH + H+
show the reaction diagram
11-cis-retinol + NADP+
11-cis-retinal + NADPH
show the reaction diagram
-
-
-
-
?
11-cis-retinol + NADP+
11-cis-retinal + NADPH + H+
show the reaction diagram
2(R),3(S)-homoisocitrate + NAD+
alpha-ketoadipate + NADH + CO2 + H+
show the reaction diagram
-
with homoisocitrate as the substrate, no primary deuterium isotope effect is observed, and a small 13C kinetic isotope effect indicates that the decarboxylation step contributes only slightly to rate limitation
-
-
?
3-carboxy-2-hydroxyadipate + NAD+
2-oxoadipate + CO2 + NADH
show the reaction diagram
3-isopropylmalate + NAD+
?
show the reaction diagram
3-vinylmalate + NAD+
?
show the reaction diagram
9-cis-retinol + NAD+
9-cis-retinal + NADH + H+
show the reaction diagram
-
microsomal preparations of RDH10 are not active in presence of NADP+
-
-
r
9-cis-retinol + NADP+
9-cis-retinal + NADPH
show the reaction diagram
-
-
-
-
?
all-trans retinol + NAD+
all-trans-retinal + NADH + H+
show the reaction diagram
-
no significant difference in the binding constants of NADP+ and NADPH versus NAD+ and NADH
-
-
r
all-trans retinol + NADP+
all-trans-retinal + NADPH + H+
show the reaction diagram
-
no significant difference in the binding constants of NADP+ and NADPH versus NAD+ and NADH
-
-
r
all-trans-retinal + NADPH + H+
all-tans-retinol + NADP+
show the reaction diagram
-
-
-
-
r
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
show the reaction diagram
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
show the reaction diagram
all-trans-retinol + NADPH
all-trans-retinal + NADP+
show the reaction diagram
-
-
-
-
r
ethylmalate + NAD+
?
show the reaction diagram
homoisocitrate + NAD+
?
show the reaction diagram
homoisocitrate + NAD+
alpha-ketoadipate + NADH + CO2
show the reaction diagram
-
-
-
-
r
homoisocitrate + NAD+
alpha-ketoadipate + NADH + CO2 + H+
show the reaction diagram
-
-
-
-
r
isocitrate + NAD+
?
show the reaction diagram
isocitrate + NAD+
? + NADH + H+
show the reaction diagram
-
low activity
-
-
?
isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
?
threo-D-isocitric acid + NAD+
?
show the reaction diagram
-
with isocitrate as the substrate, primary deuterium and 13C isotope effects indicate that hydride transfer and decarboxylation steps contribute to rate limitation, and that the decarboxylation step is the more rate-limiting of the two. The multiple-substrate deuterium/13C isotope effects suggest a stepwise mechanism with hydride transfer preceding decarboxylation
-
-
?
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate + NAD+
? + NADH + CO2
show the reaction diagram
-
-
-
-
?
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate + NAD+
? + NADH + CO2
show the reaction diagram
-
-
-
-
?
additional information
?
-